Evaluation of the osteogenesis and osseointegration of titanium alloys coated with graphene: an in vivo study

The aim of this study was to investigate whether a surface coating with graphene could enhance the surface bioactivation of titanium alloys (Ti 6 Al 4 V) to further accelerate in vivo osteogenesis and osseointegration at the implant surface. In this study, a New Zealand white rabbit femoral condyle...

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Bibliographic Details
Published in:	Scientific reports Vol. 8; no. 1; pp. 1843 - 10
Main Authors:	Li, Kewen, Wang, Chunhui, Yan, Jinhong, Zhang, Qi, Dang, Baoping, Wang, Zhuo, Yao, Yun, Lin, Kaifeng, Guo, Zhongshang, Bi, Long, Han, Yisheng
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30-01-2018 Nature Publishing Group
Subjects:	13/107 14/105 631/1647 631/1647/767/1424 Alloys Alloys - chemistry Alloys - pharmacology Animals Apposition Biological activity Bone growth Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Computed tomography Femur Graphite - chemistry Graphite - pharmacology Humanities and Social Sciences Male Materials Testing - methods multidisciplinary Osseointegration Osseointegration - drug effects Osteogenesis Osteogenesis - drug effects Prostheses and Implants Rabbits Science Science (multidisciplinary) Surface Properties - drug effects Titanium Titanium - chemistry Titanium - pharmacology Titanium alloys X-Ray Microtomography - methods
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Summary:	The aim of this study was to investigate whether a surface coating with graphene could enhance the surface bioactivation of titanium alloys (Ti 6 Al 4 V) to further accelerate in vivo osteogenesis and osseointegration at the implant surface. In this study, a New Zealand white rabbit femoral condyle defect model was established. After 4, 12 and 24 weeks, biomechanical testing, micro-computed tomography (Micro-CT) analyses and histological observations were performed. At the highest push-out forces during the test, microstructure parameters, such as the bone volume/total volume fraction (BV/TV) and mineral apposition rate (MAR), of the new bone were significantly higher in the graphene-coated Ti 6 Al 4 V group (G-Ti 6 Al 4 V) than in the Ti 6 Al 4 V group ( P < 0.05). Van Gieson (VG) staining showed that the G-Ti 6 Al 4 V group had more new bone formation than the Ti 6 Al 4 V group, and the G-Ti 6 Al 4 V group showed a closer fit between the bone and implant. In conclusion, graphene might be a novel type of nano-coating material for enhancing the surface biological activity of Ti-based alloy materials and may further promote in vivo osteogenesis and osseointegration.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-018-19742-y