Search Results - "Danes, Jeanne M"

Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch by Palma, Flavio R, He, Chenxia, Danes, Jeanne M, Paviani, Veronica, Coelho, Diego R, Gantner, Benjamin N, Bonini, Marcelo G

“…Reactive oxygen species (ROS) are now widely recognized as central mediators of cell signaling. Mitochondria are major sources of ROS. It is now clear that…”
Get more information

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance by Palma, Flavio R., Coelho, Diego R., Pulakanti, Kirthi, Sakiyama, Marcelo J., Huang, Yunping, Ogata, Fernando T., Danes, Jeanne M., Meyer, Alison, Furdui, Cristina M., Spitz, Douglas R., Gomes, Ana P., Gantner, Benjamin N., Rao, Sridhar, Backman, Vadim, Bonini, Marcelo G.

“…Chromatin structure is regulated through posttranslational modifications of histone variants that modulate transcription. Although highly homologous, histone…”
Get full text

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance by Palma, Flavio R., Coelho, Diego R., Pulakanti, Kirthi, Sakiyama, Marcelo J., Huang, Yunping, Ogata, Fernando T., Danes, Jeanne M., Meyer, Alison, Furdui, Cristina M., Spitz, Douglas R., Gomes, Ana P., Gantner, Benjamin N., Rao, Sridhar, Backman, Vadim, Bonini, Marcelo G.

Get full text

Estrogen Down-Regulation of the Corepressor N-CoR: Mechanism and Implications for Estrogen Derepression of N-CoR-Regulated Genes by Frasor, Jonna, Danes, Jeanne M., Funk, Cory C., Katzenellenbogen, Benita S., Chambon, Pierre

“…The nuclear receptor corepressor N-CoR plays a crucial role in the repressive activity of diverse transcription factors, yet little is known about what…”
Get full text

Arsenic and other metals as phenotype driving electrophiles in carcinogenesis by Danes, Jeanne M., Palma, Flavio R., Bonini, Marcelo G.

“…There are several sources of heavy metal exposures whether occupational or environmental. These are connected both with the existence of natural reservoirs of…”
Get full text

Histone deacetylase inhibitor-based chromatin precipitation for identification of targeted genomic loci by Hanigan, Thomas W, Danes, Jeanne M, Taha, Taha Y, Frasor, Jonna, Petukhov, Pavel A

“…Histone deacetylase (HDAC) catalyzes the removal of acetyl marks from histones, effectively regulating gene expression. Genome wide chromatin…”
Get full text

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer by He, Chenxia, Danes, Jeanne M., Hart, Peter C., Zhu, Yueming, Huang, Yunping, deAbreu, Andre Luelsdorf, O’Brien, Joseph, Mathison, Angela J., Tang, Binwu, Frasor, Jonna M., Wakefield, Lalage M., Ganini, Douglas, Stauder, Erich, Zielonka, Jacek, Gantner, Benjamin N., Urrutia, Raul A., Gius, David, Bonini, Marcelo G.

“…Mitochondrial superoxide dismutase (SOD2) suppresses tumor initiation but promotes invasion and dissemination of tumor cells at later stages of the disease…”
Get full text

Coactivation of Estrogen Receptor and IKKβ Induces a Dormant Metastatic Phenotype in ER-Positive Breast Cancer by El-Shennawy, Lamiaa, Dubrovskyi, Oleksii, Kastrati, Irida, Danes, Jeanne M, Zhang, Yiqun, Whiteley, Herbert E, Creighton, Chad J, Frasor, Jonna

“…A growing body of evidence suggests that the inflammatory NFκB pathway is associated with the progression of ER tumors to more aggressive stages. However, it…”
Get full text

Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity by Coelho, Diego R, Palma, Flavio R, Paviani, Veronica, He, Chenxia, Danes, Jeanne M, Huang, Yunping, Calado, Juliana C P, Hart, Peter C, Furdui, Cristina M, Poole, Leslie B, Schipma, Matthew J, Bonini, Marcelo G

“…The dichotomous behavior of superoxide dismutase-2 (SOD2) in cancer biology has long been acknowledged and more recently linked to different posttranslational…”
Get full text

Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer by Danes, Jeanne M., Abreu, Andre L. P., Kerketta, Romica, Huang, Yunping, Palma, Flavio R., Gantner, Benjamin N., Mathison, Angela J., Urrutia, Raul A., Bonini, Marcelo G.

“…Inorganic arsenic (iAs/As2O32−) is an environmental toxicant found in watersheds around the world including in densely populated areas. iAs is a class I…”
Get full text

AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism by Palma, Flavio R., Ratti, Bianca A., Paviani, Veronica, Coelho, Diego R., Miguel, Rodrigo, Danes, Jeanne M., Zaichik, Sofia V., de Abreu, Andre L., Silva, Sueli O., Chen, Yiliang, Silverstein, Roy L., Karan, Uppal, Jones, Dean P., Bonini, Marcelo G.

“…Epidemiologic studies in diabetic patients as well as research in model organisms have indicated the potential of metformin as a drug candidate for the…”
Get full text

A Cell-Permeable Stapled Peptide Inhibitor of the Estrogen Receptor/Coactivator Interaction by Speltz, Thomas E, Danes, Jeanne M, Stender, Joshua D, Frasor, Jonna, Moore, Terry W

“…We and others have proposed that coactivator binding inhibitors, which block the interaction of estrogen receptor and steroid receptor coactivators, may…”
Get full text

Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer by Brovkovych, Viktor, Izhar, Yasir, Danes, Jeanne M., Dubrovskyi, Oleskii, Sakallioglu, Isin T., Morrow, Lauren M., Atilla-Gokcumen, G. Ekin, Frasor, Jonna

“…Given the dependence of cancers on de novo lipogenesis, we tested the effect of fatostatin, a small molecule thought to target this pathway by blocking…”
Get full text

Profiling of Estrogen Up- and Down-Regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype by Frasor, Jonna, Danes, Jeanne M, Komm, Barry, Chang, Ken C. N, Lyttle, C. Richard, Katzenellenbogen, Benita S

“…Estrogens are known to regulate the proliferation of breast cancer cells and to alter their cytoarchitectural and phenotypic properties, but the gene networks…”
Get full text

Selective estrogen receptor modulators: Discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells by FRASOR, Jonna, STOSSI, Fabio, DANES, Jeanne M, KOMM, Barry, LYTTLE, C. Richard, KATZENELLENBOGEN, Benita S

“…Selective estrogen receptor modulators (SERMs) such as tamoxifen are effective in the treatment of many estrogen receptor-positive breast cancers and have also…”
Get full text

Response-Specific and Ligand Dose-Dependent Modulation of Estrogen Receptor (ER) α Activity by ERβ in the Uterus by Frasor, Jonna, Barnett, Daniel H, Danes, Jeanne M, Hess, Rex, Parlow, Albert F, Katzenellenbogen, Benita S

“…Estrogen is of great importance in the regulation of uterine function. The aim of this study was to examine the individual physiological roles of each of the…”
Get full text

Fatty acid desaturation and triglyceride accumulation protects breast cancer cells against fatostatin induced apoptosis by Brovkovych, Viktor, Danes, Jeanne M., Sakallioglu, Isin T., Atilla‐Gokcumen, G. Ekin, Frasor, Jonna

“…Abstract only It is well established that cancer cells depend on de novo lipid synthesis to provide necessary membrane and signaling lipids for cell…”
Get full text

Abstract 1810: Stapled peptide inhibitors of mutant estrogen receptor/coactivator interactions by Speltz, Thomas E., Danes, Jeanne M., Fanning, Sean W., Mayne, Christopher G., Tajkhorshid, Emad, Greene, Geoffrey L., Frasor, Jonna M., Moore, Terry W.

“…Abstract A current limitation in treating estrogen receptor-positive breast cancer is the development of resistance to endocrine therapy. Among the many…”
Get full text

Selective Estrogen Receptor Modulators by Frasor, Jonna, Stossi, Fabio, Danes, Jeanne M., Komm, Barry, Lyttle, C. Richard, Katzenellenbogen, Benita S.

“…Abstract Selective estrogen receptor modulators (SERMs) such as tamoxifen are effective in the treatment of many estrogen receptor-positive breast cancers and…”
Get full text

Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus by Frasor, Jonna, Barnett, Daniel H, Danes, Jeanne M, Hess, Rex, Parlow, Albert F, Katzenellenbogen, Benita S

“…Estrogen is of great importance in the regulation of uterine function. The aim of this study was to examine the individual physiological roles of each of the…”
Get full text