Search Results - "Danenberg, P"

ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine by Ceppi, P, Volante, M, Novello, S, Rapa, I, Danenberg, KD, Danenberg, PV, Cambieri, A, Selvaggi, G, Saviozzi, S, Calogero, R, Papotti, M, Scagliotti, GV

“…Background: Pivotal studies indicate a role of excision repair cross-complementation 1 (ERCC1) gene and ribonucleotide reductase M1 (RRM1) gene in conferring a…”
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Dynamic changes in RAS gene status in circulating tumour DNA: a phase II trial of first-line FOLFOXIRI plus bevacizumab for RAS-mutant metastatic colorectal cancer (JACCRO CC-11) by Sunakawa, Y., Satake, H., Usher, J., Jaimes, Y., Miyamoto, Y., Nakamura, M., Kataoka, M., Shiozawa, M., Takagane, A., Terazawa, T., Watanabe, T., Ishiguro, K., Tanaka, C., Takeuchi, M., Fujii, M., Danenberg, K., Danenberg, P.V., Lenz, H.-J., Sekikawa, T., Ichikawa, W.

“…Few prospective studies have used liquid biopsy testing in RAS-mutant metastatic colorectal cancer (mCRC), and its clinical significance remains unknown…”
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ERCC1 and Thymidylate Synthase mRNA Levels Predict Survival for Colorectal Cancer Patients Receiving Combination Oxaliplatin and Fluorouracil Chemotherapy by SHIROTA, Yoshinori, STOEHLMACHER, Jan, BRABENDER, Jan, XIONG, Yi-Ping, UETAKE, Hiroyuki, DANENBERG, Kathleen D, GROSHEN, Susan, TSAO-WEI, Denise D, DANENBERG, Peter V, LENZ, Heinz-Josef

“…To test the hypotheses of whether the relative mRNA expression of the thymidylate synthase (TS) gene and the excision cross-complementing (ERCC1) gene are…”
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Colorectal Tumors Responding to 5-Fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, and Thymidine Phosphorylase by SALONGA, D, DANENBERG, K. D, DANENBERG, P. V, JOHNSON, M, METZGER, R, GROSHEN, S, TSAO-WEI, D. D, LENZ, H.-J, LEICHMAN, C. G, LEICHMAN, L, DIASIO, R. B

“…We had previously shown that high gene expressions (mRNA levels) of thymidylate synthase ( TS ; Leichman et al. , J. Clin. Oncol., 15: 3223–3229, 1997) and…”
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Gene mutation status in circulating tumor DNA (ctDNA) and first-line FOLFOXIRI plus bevacizumab (bev) in metastatic colorectal cancer (mCRC) harboring RAS mutation by Sunakawa, Y, Usher, J, Satake, H, Jaimes, Y, Miyamoto, Y, Nakamura, M, Kataoka, M, Shiozawa, M, Takagane, A, Terazawa, T, Watanabe, T, Ishigure, K, Tanaka, C, Sekikawa, T, Takeuchi, M, Fujii, M, Danenberg, K, Danenberg, P V, Lenz, H-J, Ichikawa, W

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Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin by Leichman, C G, Lenz, H J, Leichman, L, Danenberg, K, Baranda, J, Groshen, S, Boswell, W, Metzger, R, Tan, M, Danenberg, P V

“…Response rates to fluorouracil (5-FU)-based therapy remain low. As new, active agents are being tested, information regarding specific intratumoral genetic…”
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Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma by EADS, Cindy A, LORD, Reginald V, LAIRD, Peter W, SKINNER, Kristin A, KURUMBOOR, Soudamini K, WICKRAMASINGHE, Kumari, SKINNER, Margaret L, LONG, Tiffany I, PETERS, Jeffrey H, DEMEESTER, Tom R, DANENBERG, Kathleen D, DANENBERG, Peter V

“…Esophageal adenocarcinoma (EAC) is thought to develop through a multistage process in which Barrett's metaplasia progresses through low- and high-grade…”
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Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival by Lenz, H J, Leichman, C G, Danenberg, K D, Danenberg, P V, Groshen, S, Cohen, H, Laine, L, Crookes, P, Silberman, H, Baranda, J, Garcia, Y, Li, J, Leichman, L

“…We tested the hypothesis that polymerase chain reaction (PCR) quantitation of the enzyme thymidylate synthase (TS) within a primary adenocarcinoma of the…”
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CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression by EADS, C. A, DANENBERG, K. D, KAWAKAMI, K, SALTZ, L. B, DANENBERG, P. V, LAIRD, P. W

“…The molecular basis of aberrant hypermethylation of CpG islands observed in a subset of human colorectal tumors is unknown. One potential mechanism is the…”
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Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase by BANERJEE, D, GORLICK, R, KEMENY, N, BERTINO, J. R, LIEFSHITZ, A, DANENBERG, K, DANENBERG, P. C, DANENBERG, P. V, KLIMSTRA, D, JHANWAR, S, CORDON-CARDO, C, FONG, Y

“…We recently reported that forced overexpression of the transcription factor E2F-1 in human HT-1080 fibrosarcoma cells resulted in corresponding high levels of…”
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Rapid Activation of MDR1 Gene Expression in Human Metastatic Sarcoma after in Vivo Exposure to Doxorubicin by ABOLHODA, A, WILSON, A. E, ROSS, H, DANENBERG, P. V, BURT, M, SCOTTO, K. W

“…Overexpression of P-glycoprotein (Pgp), a multidrug transporter encoded by the MDR1 gene, is associated with chemoresistance in some human solid tumor…”
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High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil by METZGER, R, DANENBERG, K, LEICHMAN, C. G, SALONGA, D, SCHWARTZ, E. L, WADLER, S, LENZ, H.-J, GROSHEN, S, LEICHMAN, L, DANENBERG, P. V

“…The gene expression levels of the nucleoside cleavage enzyme/angiogenic factor thymidine phosphorylase (TP), also known as platelet-derived endothelial cell…”
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2008 Non-Invasive testing of gene expressions using cell-free RNA increases the chemotherapy target information generated from cell-free DNA testing by Danenberg, K, Lenz, H.J, Usher, J, Zhang, W, El-khoueiry, R, Li, J, Elshimali, Y, Huang, X, Dang, M, Sturdevant, T, Jaimes, Y, Findlater, R, Grino, M, Danenberg, P

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TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and -2 clinical trials by Grimminger, P P, Shi, M, Barrett, C, Lebwohl, D, Danenberg, K D, Brabender, J, Vigen, C L P, Danenberg, P V, Winder, T, Lenz, H-J

“…To validate established cutoff levels of thymidylate synthase (TS) and excision repair cross-complementing (ERCC-1) intratumoral mRNA expressions in tumor…”
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ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy by Metzger, R, Leichman, C G, Danenberg, K D, Danenberg, P V, Lenz, H J, Hayashi, K, Groshen, S, Salonga, D, Cohen, H, Laine, L, Crookes, P, Silberman, H, Baranda, J, Konda, B, Leichman, L

“…We have previously shown that relative thymidylate synthase (TS) mRNA levels in primary gastric adenocarcinomas treated with fluorouracil (5-FU) and cisplatin…”
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Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors by JOHNSTON, P. G, LENZ, H.-J, LEICHMAN, C. G, DANENBERG, K. D, ALLEGRA, C. J, DANENBERG, P. V, LEICHMAN, L

“…Thymidylate synthase (TS) is the target enzyme for 5-fluorouracil (5-FU). We have correlated TS protein and gene expression with the response in patients with…”
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p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival by LENZ, H.-J, HAYASHI, K, LEICHMAN, C. G, SALONGA, D, DANENBERG, K. D, DANENBERG, P. V, METZGER, R, BANERJEE, D, BERTINO, J. R, GROSHEN, S, LEICHMAN, L. P

“…Recent studies suggest that there may be a strong correlation between the p53 status of a tumor and a patient's response to chemotherapy. Therefore, we…”
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Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib) by Wilson, P M, Yang, D, Azuma, M, Shi, M M, Danenberg, K D, Lebwohl, D, Sherrod, A, Ladner, R D, Zhang, W, Danenberg, P V, Trarbach, T, Folprecht, G, Meinhardt, G, Lenz, H-J

“…The phase III CONFIRM clinical trials demonstrated that metastatic colorectal cancer patients with elevated serum lactate dehydrogenase (LDH) had improved…”
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Thymidylate synthase inhibitors by Danenberg, P V, Malli, H, Swenson, S

“…Thymidylate synthase (TS) is a critical enzyme for DNA replication and cell growth because it is the only de novo source of thymine nucleotide precursors for…”
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p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site by LENZ, H.-J, DANENBERG, K. D, LEICHMAN, C. G, FLORENTINE, B, JOHNSTON, P. G, GROSHEN, S, LINYUN ZHOU, YI PING XIONG, DANENBERG, P. V, LEICHMAN, L. P

“…We initiated a retrospective study to determine whether p53 status and thymidylate synthase (TS) protein expression in primary colon tumors influence…”
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