Search Results - "Danek, Nicole"

Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape by Martin, Constance J, Datta, Abhishek, Littlefield, Christopher, Kalra, Ashish, Chapron, Christopher, Wawersik, Stefan, Dagbay, Kevin B, Brueckner, Christopher T, Nikiforov, Anastasia, Danehy, Jr, Francis T, Streich, Jr, Frederick C, Boston, Christopher, Simpson, Allison, Jackson, Justin W, Lin, Susan, Danek, Nicole, Faucette, Ryan R, Raman, Pichai, Capili, Allan D, Buckler, Alan, Carven, Gregory J, Schürpf, Thomas

“…Despite breakthroughs achieved with cancer checkpoint blockade therapy (CBT), many patients do not respond to anti-programmed cell death-1 (PD-1) due to…”
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1223 Non-viral targeted knock-in of a KRAS G12D specific TCR, CD8αβ, and chimeric cytokine receptor in the TRAC locus outperforms lentiviral-based engineering of T cells by Narayan, Santosh, Drain, Allison P, Swanson, Nathaniel, Rouillard, Nicholas, Warner, Tyler, Danek, Nicole, Gareau, Ken, Black, Cheryl, Parsons, James, Thomas, Anthony, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Nguyen, Vince, Priyata, Iqraa, Vidyasagar, Sarah, Francis, Joshua, He, Xingyue, Browne, Patrick J, Lamothe, Rebecca C, Storlie, Meghan D, Cost, Gregory J, Schmitt, Thomas M, Greenberg, Philip D, Chandran, Smita S, Klebanoff, Christopher A, Gupta, Ankit, Hallet, Damien, Shapiro, Gary, Nguyen, Kim, Vincent, Loic

“…BackgroundThe AFNT-212 cell therapy consists of autologous CD8+ and CD4+ T cells expressing 1) a T Cell Receptor (TCR) specific for the prevalent oncogenic…”
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355 Directing a high avidity KRAS G12D-specific TCR engineered with a CD8αβ co-receptor and chimeric cytokine receptor using non-viral knock-in enhances anti-tumor responses by Drain, Allison P, Rouillard, Nicholas, Swanson, Nathaniel, Narayan, Santosh, Warner, Tyler, Danek, Nicole, Gareau, Ken, Black, Cheryl, Parsons, James, Thomas, Anthony, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Nguyen, Vince, Priyata, Iqraa, Vidyasagar, Sarah, Francis, Joshua, He, Xingyue, Browne, Patrick J, Lamothe, Rebecca C, Storlie, Meghan D, Cost, Gregory J, Schmitt, Thomas M, Greenberg, Philip D, Chandran, Smita S, Klebanoff, Christopher A, Gupta, Ankit, Hallet, Damien, Shapiro, Gary, Nguyen, Kim, Vincent, Loic

“…BackgroundAdoptive T cell therapy has demonstrated clinical activity in a subset of patients with solid tumors; however, consistent responses will require…”
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Abstract 9: AFNT-212: A TRAC -knocked-in KRASG12D-specific TCR-T cell product enhanced with CD8αβ and a chimeric cytokine receptor for treatment of solid cancers by Drain, Allison, Rouillard, Nicholas, Swanson, Nathaniel, Canestraro, Martina, Narayan, Santosh, Warner, Tyler, Danek, Nicole, Gareau, Ken, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Priyata, Iqraa, Vidyasagar, Sarah, Riggins-Walker, Taylor, Liu, Hui-Wen, Pechhold, Klaus, Brown, Lauren, Francis, Joshua, He, Xingyue, Browne, Patrick, Lamothe, Rebecca, Storlie, Meghan, Cost, Gregory, Schmitt, Thomas M., Greenberg, Philip D., Chandran, Smita S., Klebanoff, Christopher A., Lam, Hubert, Gupta, Ankit, Hallet, Damien, Shapiro, Gary, Nguyen, Kim, Vincent, Loïc

“…The KRASG12D mutation is an ideal target for anti-cancer therapies as its expression is typically clonal, restricted to cancer tissue, and is among the most…”
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Effect of Engineered Matrix Environment on Adipogenesis of Adult Adipose-Derived Stem Cells by Danek, Nicole A

“…Obesity has become a major concern for today's society over the last decades without any foreseeable solution to the problem. However, it is known that adipose…”
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