Search Results - "Dando, Sandra A"

Modulation of Tight Junctions does Not Predict Oral Absorption of Hydrophilic Compounds: Use of Caco-2 and Calu-3 Cells by Kamath, Amrita V, Morrison, Richard A, Mathias, Neil R, Dando, Sandra A, Marino, Anthony M, Chong, Sae-Ho

“…Permeability estimates using Caco-2 cells do not accurately predict the absorption of hydrophilic drugs that are primarily absorbed via the paracellular…”
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Modulation of tight junctions does not predict oral absorption of hydrophilic compounds: use of Caco-2 and Calu-3 cells by Kamath, Amrita V, Morrison, Richard A, Mathias, Neil R, Dando, Sandra A, Marino, Anthony M, Chong, Saeho

“…Permeability estimates using Caco-2 cells do not accurately predict the absorption of hydrophilic drugs that are primarily absorbed via the paracellular…”
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A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 2: affinities of ACE inhibitors by Moore, Vanessa A, Irwin, William J, Timmins, Peter, Lambert, Peter A, Chong, Saeho, Dando, Sandra A, Morrison, Richard A

“…Purpose: To assess the affinities of a series of ACE inhibitors for the di/tri/oligopeptide transport system (DTS) using a rapid in vitro system. Methods:…”
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A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 1: system characterisation by Moore, Vanessa A, Irwin, William J, Timmins, Peter, Chong, Saeho, Dando, Sandra A, Morrison, Richard A

“…Purpose: To establish an in vitro system for the rapid assessment of the affinities of potential substrates for the di/tri/oligopeptide transport system (DTS)…”
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Evaluation of Biocoat® intestinal epithelium differentiation environment (3-day cultured caco-2 cells) as an absorption screening model with improved productivity by CHONG, S, DANDO, S. A, MORRISON, R. A

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In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system by SAEHO CHONG, DANDO, S. A, SOUCEK, K. M, MORRISON, R. A

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Prodrugs of BMS-183920: metabolism and permeability considerations by Obermeier, M T, Chong, S, Dando, S A, Marino, A M, Ryono, D E, Starrett-Arroyo, A, DiDonato, G C, Warrack, B M, White, R E, Morrison, R A

“…The oral bioavailability of BMS-183920, a diacidic, potent angiotensin II receptor antagonist, is low in rats (approximately 11%). In vivo studies in bile…”
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