Search Results - "Danda, Lucas José de Alencar"

Optimizing Nonsink Dissolution Testing for Amorphous Solid Dispersions: Exploring Sample Handling Variables by Danda, Lucas José de Alencar, Amaral, Alane Rafaela de Carvalho, Soares-Sobrinho, José Lamartine, Soares, Monica Felts de La Roca

“…This study aims to investigate key variables affecting the dissolution of amorphous pharmaceuticals. We examined sample treatment methods (centrifugation vs…”
Get full text

A green analytical method for the analysis of polycyclic aromatic hydrocarbons in oral fluids from crack smokers by Rossiter, Pavla Lôbo, de Alencar Danda, Lucas José, Pimentel, Maria Fernanda, Almeida Silva de Santana, Danielle Cristine, Malagueño de Santana, Fernando José

“…Develop and validate a method of solid-phase microextraction (SPME) and liquid chromatography to investigate three major polycyclic aromatic hydrocarbons…”
Get full text

Amorphous solid dispersions in high-swelling, low-substituted hydroxypropyl cellulose for enhancing the delivery of poorly soluble drugs by Danda, Lucas José de Alencar, Christinne Rocha de Medeiros Schver, Giovanna, Lamartine Soares Sobrinho, José, Lee, Ping I., Felts de La Roca Soares, Monica

“…[Display omitted] Amorphous solid dispersions (ASDs) based on water-insoluble hydrophilic polymers can sustain supersaturation in their kinetic solubility…”
Get full text

Combining amorphous solid dispersions for improved kinetic solubility of posaconazole simultaneously released from soluble PVP/VA64 and an insoluble ammonio methacrylate copolymer by Danda, Lucas José de Alencar, Batista, Lorena de Medeiros, Melo, Victor Carvalho Silveira, Soares Sobrinho, José Lamartine, Soares, Monica Felts de La Roca

“…The aim of this study was to evaluate the potential of combining multiple ASDs based on water soluble and insoluble polymers to reach and maintain poorly…”
Get full text

Dissolution performance of acyclovir released from layered double hydroxide clays prepared via spray-drying and lyophilization techniques by Aguilera, Cindy Siqueira Britto, Silva, Laysa Creusa Paes Barreto Barros, Yun, Adriana Eun He Koo, Danda, Lucas José de Alencar, de Sousa, André Luiz Moreira Domingues, Timóteo, Taysa Renata Ribeiro, Soares, Monica Felts de La Roca, Rolim, Larissa Araújo, da Silva, Rosali Maria Ferreira, Neto, Pedro José Rolim

“…•MgAl-Cl-LDH:ACV complexes were prepared via spray-drying or lyophilization.•PXRD analysis and SEM images indicated drug adsorption on the clay surface.•SEM…”
Get full text

Systematic evaluation of the impact of solid-state polymorphism on the bioavailability of thalidomide by de Oliveira, Guilherme Henrique Onório, do Nascimento, Sara Batista, de Oliveira, Flávio Martins, Belo, Vinícius Silva, de Alencar Danda, Lucas José, Soares-Sobrinho, José Lamartine, Fialho, Silvia Ligório, Bedor, Danilo César Galindo, de Castro, Whocely Victor

“…Thalidomide (TLD) is used to treat erythema nodosum leprosum (ENL), multiple myeloma, aphthous ulceration and wasting syndrome in HIV patients. The API can be…”
Get full text

Simultaneous Quantification of Benznidazole and Posaconazole by HPLC-DAD Using QbD Approach by Santana, Ana Cristina Sousa Gramoza Vilarinho, Danda, Lucas José de Alencar, Nunes, Livio Cesar Cunha, Soares Sobrinho, Jose Lamartine

“…Abstract Objective To develop an analytical method to simultaneous quantification of benznidazole (BNZ) and posaconazole (POS) by high-performance liquid…”
Get full text

Layered double hydroxides of CaAl: A promising drug delivery system for increased dissolution rate and thermal stability of praziquantel by Timóteo, Taysa Renata Ribeiro, Melo, Camila Gomes de, Danda, Lucas José de Alencar, Silva, Laysa Creusa Paes Barreto Barros, Fontes, Danilo Augusto Ferreira, Silva, Paulo César Dantas, Aguilera, Cindy Siqueira Britto, Siqueira, Lidiany da Paixão, Rolim, Larissa Araújo, Rolim Neto, Pedro José

“…Layered double hydroxide (LDH) are promising drug delivery systems (DDS) for the transport of biologically active substances, with special attention to those…”
Get full text

Characterization, in vitro dissolution, and pharmacokinetics of different batches of efavirenz raw materials by Bedor, Danilo César Galindo, Bedor, Noely Camila Tavares Cavalcanti, Neto, João Gomes Pontes, José de Alencar Danda, Lucas, de Oliveira, Flávio Martins, de Oliveira, Guilherme Henrique Onório, Soares Sobrinho, José Lamartine, Beyssac, Eric, Castro, Whocely Victor de, Santana, Davi Pereira de

“…To perform the solid-state characterization and the in vitro-in vivo correlation (IVIVC) of three batches of efavirenz (EFV) active pharmaceutical ingredients…”
Get full text