Search Results - "Danciu, Oana C."

Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies by Danciu, Oana C., Holdhoff, Matthias, Peterson, Richard A., Fischer, James H., Liu, Li C., Wang, Heng, Venepalli, Neeta K., Chowdhery, Rozina, Nicholas, M. Kelly, Russell, Meredith J., Fan, Timothy M., Hergenrother, Paul J., Tarasow, Theodore M., Dudek, Arkadiusz Z.

“…Background Procaspase-3 (PC-3) is overexpressed in multiple tumour types and procaspase-activating compound 1 (PAC-1) directly activates PC-3 and induces…”
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Identification of metabolic pathways contributing to ER+ breast cancer disparities using a machine-learning pipeline by Santaliz-Casiano, Ashlie, Mehta, Dhruv, Danciu, Oana C., Patel, Hariyali, Banks, Landan, Zaidi, Ayesha, Buckley, Jermya, Rauscher, Garth H., Schulte, Lauren, Weller, Lauren Ro, Taiym, Deanna, Liko-Hazizi, Elona, Pulliam, Natalie, Friedewald, Sarah M., Khan, Seema, Kim, J. Julie, Gradishar, William, Hegerty, Scott, Frasor, Jonna, Hoskins, Kent F., Madak-Erdogan, Zeynep

“…African American (AA) women in the United States have a 40% higher breast cancer mortality rate than Non-Hispanic White (NHW) women. The survival disparity is…”
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Association of Race/Ethnicity and the 21-Gene Recurrence Score With Breast Cancer-Specific Mortality Among US Women by Hoskins, Kent F, Danciu, Oana C, Ko, Naomi Y, Calip, Gregory S

“…Given the widespread use of the 21-gene recurrence score for identifying candidates for adjuvant chemotherapy, it is important to examine the performance of…”
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If you don't measure it, you can't improve it: Success and shortcomings of genomic assays in early breast cancer by Danciu, Oana C., Chen, Zhengjia, Hoskins, Kent F.

“…The ability of genomic assays to increase the number of women with early‐stage, hormone‐dependent breast cancer who can safely avoid chemotherapy has been…”
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Tryptophan and Kynurenine Pathway Metabolites and Psychoneurological Symptoms Among Breast Cancer Survivors by Li, Hongjin, Lockwood, Mark B., Schlaeger, Judith M., Liu, Tingting, Danciu, Oana C., Doorenbos, Ardith Z.

“…Among breast cancer survivors, pain, fatigue, depression, anxiety, and sleep disturbance are common psychoneurological symptoms that cluster together…”
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Association of Social Determinants and Tumor Biology With Racial Disparity in Survival From Early-Stage, Hormone-Dependent Breast Cancer by Hoskins, Kent F, Calip, Gregory S, Huang, Hsiao-Ching, Ibraheem, Abiola, Danciu, Oana C, Rauscher, Garth H

“…Black women with hormone receptor-positive breast cancer experience the greatest racial disparity in survival of all breast cancer subtypes. The relative…”
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Reduction in Breast Cancer Death With Adjuvant Chemotherapy Among US Women According to Race, Ethnicity, and the 21-Gene Recurrence Score by Huang, Hsiao-Ching, Calip, Gregory S, Weiss, Jennifer, Simons, Yael, Gadi, V K, Danciu, Oana C, Rauscher, Garth H, Hoskins, Kent F

“…We previously showed the 21-gene breast recurrence score (RS) has lower prognostic accuracy for non-Hispanic Black (NHB) compared with non-Hispanic White (NHW)…”
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Breast cancer survivors with preserved or rescued cardiorespiratory fitness have similar cardiac, pulmonary and muscle function compared to controls by Grigoriadis, Georgios, Sherman, Sara R., Lima, Natalia S., Lefferts, Elizabeth C., Hibner, Brooks A., Ozemek, Hannah C., Danciu, Oana C., Kanaloupitis, Dimitra, Fernhall, Bo, Baynard, Tracy

“…Breast cancer survivors (BCS) have a high prevalence of cardiovascular disease and low cardiorespiratory fitness (CRF). CRF is an important predictor of…”
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Hepatitis B Reactivation in a Patient Receiving Chemotherapy for Breast Cancer: A Case Report by Remo, Mylene, Abraham, Ivy, Kankanala, Vineel, Chacra, Wadih, Danciu, Oana C

“…Hepatitis B virus (HBV) reactivation is a known complication of immunosuppressive therapy. While patients who are undergoing treatment with anti-CD20 agents or…”
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Feasibility of Acupuncture and Exploration of Metabolomic Alterations for Psychoneurological Symptoms Among Breast Cancer Survivors by Li, Hongjin, Schlaeger, Judith M., Patil, Crystal L., Danciu, Oana C., Xia, Yinglin, Sun, Jun, Doorenbos, Ardith Z.

“…Objective Approximately 24–68% of breast cancer survivors report co-occurring psychoneurological symptoms of pain, fatigue, sleep disturbance, depression, and…”
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Phase I Study of Aurora A Kinase Inhibitor Alisertib (MLN8237) in Combination With Selective VEGFR Inhibitor Pazopanib for Therapy of Advanced Solid Tumors by Shah, Hiral A, Fischer, James H, Venepalli, Neeta K, Danciu, Oana C, Christian, Sonia, Russell, Meredith J, Liu, Li C, Zacny, James P, Dudek, Arkadiusz Z

“…Pazopanib is a multikinase angiogenesis inhibitor. Alisertib is a highly selective inhibitor of mitotic Aurora A kinase. There is preclinical evidence that…”
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Phase I Study of IGF-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R by Venepalli, Neeta K, Emmadi, Rajyasree, Danciu, Oana C, Chowdhery, Rozina, Cabay, Robert J, Gaitonde, Sujata, Aardsma, Nathan, Kothari, Rajul, Liu, Li C, Fischer, James H, Zaidi, Ayesha, Russell, Meredith J, Dudek, Arkadiusz Z

“…Insulin-like growth factor-methotrexate (IGF-MTX) is a conjugate of methotrexate and 765IGF, a variant of IGF-1 with high affinity for insulin-like growth…”
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Phase I dose-escalation study of procaspase-activating compound-1 in combination with temozolomide in patients with recurrent high-grade astrocytomas by Holdhoff, Matthias, Nicholas, M Kelly, Peterson, Richard A, Maraka, Stefania, Liu, Li C, Fischer, James H, Wefel, Jeffrey S, Fan, Timothy M, Vannorsdall, Tracy, Russell, Meredith, Iacoboni, Michaella, Tarasow, Theodore M, Hergenrother, Paul J, Dudek, Arkadiusz Z, Danciu, Oana C

“…Abstract Background Procaspase-3 (PC-3) is overexpressed in various tumor types, including gliomas. Targeted PC-3 activation combined with chemotherapy is a…”
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Prolonged activity of bevacizumab in adenocarcinoma of the lung with multiple brain metastases by Danciu, Oana C., Rayani, Shayan, Michals, Edward A., Villano, J. Lee

“…Patients with lung cancer having multiple brain metastases have poor outcomes. We present long-term disease treatment in a 60-year-old woman having greater…”
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Abstract P3-14-02: Racial/ethnic differences in the benefit of adjuvant chemotherapy for breast cancer patients with an intermediate risk 21-gene recurrence score by Huang, Hsiao- Ching, Calip, Gregory S., Weiss, Jennifer, Simons, Yael, Gadi, V.K., Danciu, Oana C., Rauscher, Garth H., Hoskins, Kent F.

“…Abstract Background: The Oncotype 21-gene Recurrence Score (RS) is the most commonly ordered genomic biomarker used to inform decisions on adjuvant…”
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Abstract LB-330: Phase I study of procaspase activating compound-1 (PAC-1) for treatment of advanced malignancies by Danciu, Oana C., Holdhoff, Matthias, Peterson, Richard A., Hergenrother, Paul J., Tarasow, Theodore M., Dudek, Arkadiusz Z.

“…Abstract Background: PAC-1 is a small molecule that directly activates procaspase-3 and induces apoptosis of cancer cells. This first-in-human, phase I,…”
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Breast Cancer Survivors Improved Forearm Blood Flow Following a Single Bout of Aerobic Exercise: Preliminary Results by Grigoriadis, Georgios, Hibner, Brooks A., Schroeder, Elizabeth C., Rosenberg, Alexander J., Danciu, Oana C., Fernhall, Bo, Baynard, Tracy

“…Chemotherapy impairs endothelial and resistance artery function contributing to arterial dysfunction, a cardiovascular disease (CVD) risk factor. In healthy…”
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Abstract P1-19-30: Safety results from a phase 2 study of Palbociclib in combination with Tamoxifen as first line therapy for metastatic hormone receptor positive breast cancer by Danciu, Oana C, Hoskins, Kent, Truica, Cristina, Blaes, Anne, Tamkus, Deimante, Rana, Jatin, Pavankumar, Tandra, Green, Lauren, Liu, Li, Yu, Menggang, Toppmeyer, Deborah, O'Regan, Ruth, Wisinski, Kari

“…Abstract Background: Palbociclib is a reversible, oral, small molecule inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6). Palbociclib combined with…”
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Phase I study of procaspase activating compound-1 (PAC-1) for treatment of advanced malignancies by Danciu, Oana C., Nicholas, Martin Kelly, Holdhoff, Matthias, Peterson, Richard A., Tarasow, Theodore M, Hergenrother, Paul J., Dudek, Arkadiusz Z.

“…Abstract only…”
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Abstract CT027: Phase I study of procaspase activating compound -1 (PAC-1) in the treatment of advanced malignancies and in combination with temozolomide in refractory high-grade astrocytomas by Danciu, Oana C., Nicholas, M. Kelly, Holdhoff, Matthias, Peterson, Richard A., Venepalli, Neeta, Chowdhery, Rozina, Hergenrother, Paul J., Tarasow, Theodore M., Dudek, Arkadiusz Z.

“…Abstract Background: PAC-1 is a small molecule that directly activates procaspase-3 and induces apoptosis of cancer cells. PAC-1 crosses the…”
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