Search Results - "Dancho, Meghan"

Brain region-specific alterations in the gene expression of cytokines, immune cell markers and cholinergic system components during peripheral endotoxin-induced inflammation by Silverman, Harold A, Dancho, Meghan, Regnier-Golanov, Angelique, Nasim, Mansoor, Ochani, Mahendar, Olofsson, Peder S, Ahmed, Mohamed, Miller, Edmund J, Chavan, Sangeeta S, Golanov, Eugene, Metz, Christine N, Tracey, Kevin J, Pavlov, Valentin A

“…Inflammatory conditions characterized by excessive peripheral immune responses are associated with diverse alterations in brain function, and brain-derived…”
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Galantamine alleviates inflammation and other obesity-associated complications in high-fat diet-fed mice by Satapathy, Sanjaya K, Ochani, Mahendar, Dancho, Meghan, Hudson, Laqueta K, Rosas-Ballina, Mauricio, Valdes-Ferrer, Sergio I, Olofsson, Peder S, Harris, Yael Tobi, Roth, Jesse, Chavan, Sangeeta, Tracey, Kevin J, Pavlov, Valentin A

“…Obesity, a serious and growing health threat, is associated with low-grade inflammation that plays a role in mediating its adverse consequences. Previously, we…”
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HMGB1 Mediates Anemia of Inflammation in Murine Sepsis Survivors by Valdés-Ferrer, Sergio I, Papoin, Julien, Dancho, Meghan E, Olofsson, Peder S, Li, Jianhua, Lipton, Jeffrey M, Avancena, Patricia, Yang, Huan, Zou, Yong-Rui, Chavan, Sangeeta S, Volpe, Bruce T, Gardenghi, Sara, Rivella, Stefano, Diamond, Betty, Andersson, Ulf, Steinberg, Bettie M, Blanc, Lionel, Tracey, Kevin J

“…Patients surviving sepsis develop anemia, but the molecular mechanism is unknown. Here we observed that mice surviving polymicrobial gram-negative sepsis…”
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High-Mobility Group Box 1 Mediates Persistent Splenocyte Priming in Sepsis Survivors: Evidence From a Murine Model by Valdés-Ferrer, Sergio I, Rosas-Ballina, Mauricio, Olofsson, Peder S, Lu, Ben, Dancho, Meghan E, Li, JianHua, Yang, Huan, Pavlov, Valentin A, Chavan, Sangeeta S, Tracey, Kevin J

“…ABSTRACTSevere sepsis is a life-threatening complication of infection and injury affecting more than 700,000 people in the United States each year. Two thirds…”
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Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation by Rosas-Ballina, Mauricio, Valdés-Ferrer, Sergio I, Dancho, Meghan E, Ochani, Mahendar, Katz, David, Cheng, Kai Fan, Olofsson, Peder S, Chavan, Sangeeta S, Al-Abed, Yousef, Tracey, Kevin J, Pavlov, Valentin A

“…Abstract Inflammatory conditions characterized by excessive immune cell activation and cytokine release, are associated with bidirectional immune system-brain…”
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Sequestering HMGB1 via DNA-conjugated beads ameliorates murine colitis by Ju, Zhongliang, Chavan, Sangeeta S, Antoine, Daniel J, Dancho, Meghan, Tsaava, Teá, Li, Jianhua, Lu, Ben, Levine, Yaakov A, Stiegler, Andrew, Tamari, Yehuda, Al-Abed, Yousef, Roth, Jesse, Tracey, Kevin J, Yang, Huan

“…Inflammatory bowel disease (IBD) is chronic inflammation of the gastrointestinal tract that affects millions of people worldwide. Although the etiology of IBD…”
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Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice by Hudson, LaQueta K, Dancho, Meghan E, Li, Jianhua, Bruchfeld, Johanna B, Ragab, Ahmed A, He, Mingzhu M, Bragg, Meaghan, Lenaghan, Delaney, Quinn, Michael D, Fritz, Jason R, Tanzi, Matthew V, Silverman, Harold A, Hanes, William M, Levine, Yaakov A, Pavlov, Valentin A, Olofsson, Peder S, Roth, Jesse, Al-Abed, Yousef, Andersson, Ulf, Tracey, Kevin J, Chavan, Sangeeta S

“…Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by beta cell destruction, insulin deficiency and hyperglycemia. Activated…”
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HMGB1 mediates cognitive impairment in sepsis survivors by Chavan, Sangeeta S, Huerta, Patricio T, Robbiati, Sergio, Valdes-Ferrer, S I, Ochani, Mahendar, Dancho, Meghan, Frankfurt, Maya, Volpe, Bruce T, Tracey, Kevin J, Diamond, Betty

“…Severe sepsis, a syndrome that complicates infection and injury, affects 750,000 annually in the United States. The acute mortality rate is approximately 30%,…”
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Sequestering HMGB1 using DNA-conjugated beads ameliorates murine colitis (THER5P.840) by Yang, Huan, Ju, Zhongliang, Dancho, Meghan, Li, Jianhua, Tamari, Yehuda, Chavan, Sangeeta, Tracey, Kevin

“…Abstract Inflammatory Bowel Disease (IBD) is a chronic inflammation of the gastrointestinal tract that affects millions of people worldwide. Although the…”
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All-Thiol HMGB1 Is a Critical Inducer of Anemia in Sepsis Survivors through CXCR4 Signaling by Valdés-Ferrer, Sergio I, Blanc, Lionel, Dancho, Meghan E, Papoin, Julien, Steinberg, Bettie, Lipton, Jeffrey M, Tracey, Kevin J

“…Introduction: Each year, at least 500,000 patients will survive acute sepsis. Anemia is extremely common in sepsis survivors, further interfering with quality…”
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Removal of HMGB1 in inflammatory bowel disease using DNA-beads. (P5197) by Ju, Zhongliang, Li, Jianhua, Lu, Ben, Dancho, Meghan, Mahenda, Ochani, Chavan, Sangeeta, Tracey, Kevin, Yang, Huan

“…Abstract Inflammatory bowel disease (IBD) affects millions of Americans, and costs 1.7 billion annually. High mobility group box 1 (HMGB1) is a cytokine…”
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Positive allosteric modulation of M1 muscarinic acetylcholine receptors suppresses lethal peripheral inflammation (P5082) by Pavlov, Valentin, Ochani, Mahendar, Dancho, Meghan, Al-Abed, Yousef, Nathanson, Neil, Tracey, Kevin

“…Abstract Peripheral inflammation can be regulated by activation of brain muscarinic acetylcholine receptor (mAChR)-dependent signaling functionally associated…”
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Basal forebrain cholinergic signaling regulates peripheral cytokine responses (INC1P.349) by Pavlov, Valentin, Silverman, Harold, Dancho, Meghan, Regnier-Golanov, Angelique, Ochani, Mahendar, Hanes, William, Olofsson, Peder, Chavan, Sangeeta, Golanov, Eugene, Prado, Vania, Prado, Marco, Tracey, Kevin

“…Abstract Brain cholinergic signaling regulates peripheral cytokine release and inflammation (Nat Rev Endocrinol, 2012, 8:743). We have previously shown that…”
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Identification of emetine as a therapeutic agent that targets pigment epithelium derived factor - mediated inflammation and improves hyperglycemia in murine models of type 1 diabetes (IRM9P.728) by Hudson, LaQueta, Chavan, Sangeeta, Dancho, Meghan, Bruchfeld, Johanna, Li, Jianhua, Ragab, Ahmed, Tssava, Tea, Hanes, William, Fritz, Jason, Silverman, Harold, Tanzi, Matthew, Pavlov, Valentin, Olofsson, Peder, Al-Abed, Yousef, Tracey, Kevin

“…Abstract Pigment epithelium derived factor (PEDF) is a 50kDa secreted protein with inflammatory, antiangiogenic and neurotrophic properties. Elevated levels of…”
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Haptoglobin inhibits the pro-inflammatory activity of HMGB1. (172.19) by Yang, Huan, Levine, Jacob, Katz, David, Lu, Ben, Scheinerman, Josh, Dancho, Meghan, Ochani, Mahendar, Li, Jianhua, Chavan, Sangeeta, Warren, Shaw, Tracey, Kevin

“…Abstract Severe sepsis accounts for over 200,000 deaths in US annually (Angus et al, CCM, 2001). The mechanism involves endogenous molecules that impair organ…”
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Cholinergic activation by galantamine suppresses obesity-associated inflammation in mice (54.4) by Pavlov, Valentin, Satapathy, Sanjaya, Ochani, Mahendar, Dancho, Meghan, Hudson, LaQueta, Rosas-Ballina, Mauricio, Valdes-Ferrer, Sergio, Olofsson, Peder, Harris, Yael, Chavan, Sangeeta, Roth, Jesse, Tracey, Kevin

“…Abstract Low-grade systemic inflammation is a central event in obesity and mediates insulin resistance and other complications. Previously we discovered a role…”
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Galantamine Treatment as a Novel Therapeutic Approach in Alleviating Obesity and Obesity-Related Complications in High-Fat Diet-Fed Mice: 287 by Satapathy, Sanjaya, Ochani, Mahendar, Dancho, Meghan, Hudson, LaQueta, Rosas-Ballina, Mauricio, Valdes-Ferrer, Sergio, Olofsson, Peder, Harris, Yael, Roth, Jesse, Chavan, Sangeeta, Tracey, Kevin, Pavlov, Valentin

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Response to “HMGB1 Mediates Cognitive Impairment in Sepsis Survivors” by Chavan, Sangeeta S., Huerta, Patricio T., Robbiati, Sergio, Valdes-Ferrer, S. I., Ochani, Mahendar, Dancho, Meghan, Frankfurt, Maya, Volpe, Bruce T., Tracey, Kevin J., Diamond, Betty

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Sequestering HMGB1 via DNA-Conjugated Beads Ameliorates Murine Colitis: e103992 by Ju, Zhongliang, Chavan, Sangeeta S, Antoine, Daniel J, Dancho, Meghan, Tsaava, Tea, Li, Jianhua, Lu, Ben, Levine, Yaakov A, Stiegler, Andrew, Tamari, Yehuda

“…Inflammatory bowel disease (IBD) is chronic inflammation of the gastrointestinal tract that affects millions of people worldwide. Although the etiology of IBD…”
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