Sleep quality and daytime function in adults with cystic fibrosis and severe lung disease

It was hypothesized that adult cystic fibrosis (CF) patients with severe lung disease have impaired daytime function related to nocturnal hypoxaemia and sleep disruption. Nineteen CF patients (forced expiratory volume in one second 28+/-7% predicted) and 10 healthy subjects completed sleep diaries,...

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Bibliographic Details
Published in:	The European respiratory journal Vol. 19; no. 3; pp. 504 - 510
Main Authors:	Dancey, D.R, Tullis, E.D, Heslegrave, R, Thornley, K, Hanly, P.J
Format:	Journal Article
Language:	English
Published:	Leeds Eur Respiratory Soc 01-03-2002 Maney
Subjects:	Adult Biological and medical sciences Case-Control Studies Circadian Rhythm Cognition Disorders - diagnosis Cognition Disorders - epidemiology Cognition Disorders - etiology Cystic Fibrosis - complications Cystic Fibrosis - diagnosis Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Humans Incidence Lung Diseases - complications Lung Diseases - diagnosis Male Medical sciences Multivariate Analysis Other diseases. Semiology Polysomnography Prognosis Reaction Time Reference Values Respiratory Function Tests Risk Factors Severity of Illness Index Sleep Wake Disorders - diagnosis Sleep Wake Disorders - epidemiology Sleep Wake Disorders - etiology Statistics, Nonparametric Human Pathophysiology Respiratory disease Metabolic diseases Exploration Cystic fibrosis Genetic disease Quality of life Dyspnea Lung function Sleep Digestive diseases Pancreatic disease
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Summary:	It was hypothesized that adult cystic fibrosis (CF) patients with severe lung disease have impaired daytime function related to nocturnal hypoxaemia and sleep disruption. Nineteen CF patients (forced expiratory volume in one second 28+/-7% predicted) and 10 healthy subjects completed sleep diaries, overnight polysomnography (PSG), and assessment of daytime sleepiness and neurocognitive function. CF patients tended to report more awakenings (0.7+/-0.5 versus 0.3+/-0.2 x h(-1), p=0.08), and PSG revealed reduced sleep efficiency (71+/-25 versus 93+/-4%, p=0.004) and a higher frequency of awakenings (4.2+/-2.7 versus 2.4+/-1.4 x h(-1), p=0.06). Mean arterial oxygen saturation during sleep was lower in CF patients (84.4+/-6.8 versus 94.3+/-1.5%, p<0.0001) and was associated with reduced sleep efficiency (regression coefficient (r)=0.57, p=0.014). CF patients had short sleep latency on the multiple sleep latency test (6.7+/-3 min). The CF group reported lower levels of activation and happiness and greater levels of fatigue (p<0.01), which correlated with indices of sleep loss, such as sleep efficiency (r=0.47, p=10.05). Objective neurocognitive performance was also impaired in CF patients, reflected by lower throughput for simple addition/subtraction, serial reaction and colour-word conflict. The authors concluded that adult cystic fibrosis patients with severe lung disease have impaired neurocognitive function and daytime sleepiness, which is partly related to chronic sleep loss and nocturnal hypoxaemia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0903-1936 1399-3003
DOI:	10.1183/09031936.02.00088702