Metriculator: quality assessment for mass spectrometry-based proteomics

Quality control in mass spectrometry-based proteomics remains subjective, labor-intensive and inconsistent between laboratories. We introduce Metriculator, a software designed to facilitate long-term storage of extensive performance metrics as introduced by NIST in 2010. Metriculator features a web...

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Bibliographic Details
Published in:	Bioinformatics Vol. 29; no. 22; pp. 2948 - 2949
Main Authors:	Taylor, Ryan M, Dance, Jamison, Taylor, Russ J, Prince, John T
Format:	Journal Article
Language:	English
Published:	England 15-11-2013
Subjects:	Humans Internet Mass Spectrometry - standards Proteomics - standards Quality Control Software
Online Access:	Get full text
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Summary:	Quality control in mass spectrometry-based proteomics remains subjective, labor-intensive and inconsistent between laboratories. We introduce Metriculator, a software designed to facilitate long-term storage of extensive performance metrics as introduced by NIST in 2010. Metriculator features a web interface that generates interactive comparison plots for contextual understanding of metric values and an automated metric generation toolkit. The comparison plots are designed for at-a-glance determination of outliers and trends in the datasets, together with relevant statistical comparisons. Easy-to-use quantitative comparisons and a framework for integration plugins will encourage a culture of quality assurance within the proteomics community. Available under the MIT license at http://github.com/princelab/metriculator.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1367-4803 1367-4811 1460-2059
DOI:	10.1093/bioinformatics/btt510