Search Results - "Dan, Yukihiko"

MTH1, an Oxidized Purine Nucleoside Triphosphatase, Suppresses the Accumulation of Oxidative Damage of Nucleic Acids in the Hippocampal Microglia during Kainate-Induced Excitotoxicity by Kajitani, Kosuke, Yamaguchi, Hiroo, Dan, Yukihiko, Furuichi, Masato, Kang, Dongchon, Nakabeppu, Yusaku

“…Enhanced oxidative stress has been implicated in the excitotoxicity of the CNS, and 8-oxo-7,8-dihydro-guanine (8-oxoG), a major type of oxidative damage in…”
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Influence of SLCO1B3 Gene Polymorphism on the Pharmacokinetics of Digoxin in Terminal Renal Failure by Tsujimoto, Masayuki, Dan, Yukihiko, Hirata, Sumio, Ohtani, Hisakazu, Sawada, Yasufumi

“…Digoxin (DX) is mainly excreted unchanged in the urine. In patients undergoing hemodialysis (HD patients), the relative contribution of hepatic elimination is…”
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Polymorphisms and Linkage Disequilibrium of the OATP8 (OATP1B3) Gene in Japanese Subjects by Tsujimoto, Masayuki, Hirata, Sumio, Dan, Yukihiko, Ohtani, Hisakazu, Sawada, Yasufumi

“…OATP8, a member of the organic anion-transporting polypeptide family, is expressed on the sinusoidal membrane of hepatocytes, and transports endogenous organic…”
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Kinetic Analysis of the Transport of Salicylic Acid, a Nonsteroidal Anti-inflammatory Drug, across Human Placenta by SHINTAKU, Kyohei, ARIMA, Yuka, HORI, Satoko, OHTANI, Hisakazu, SAWADA, Yasufumi, DAN, Yukihiko, TAKEDA, Tsutomu, KOGUSHI, Kentaro, TSUJIMOTO, Masayuki, NAGATA, Hideaki, SATOH, Shoji, TSUKIMORI, Kiyomi, NAKANO, Hitoo

“…The aim of this study was to develop a pharmacokinetic model to describe the transplacental transfer of drugs, based on the human placental perfusion study…”
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Polymorphism of MDR1 Gene in Healthy Japanese Subjects: A Novel SNP with an Amino Acid Substitution (Glu108Lys) by Honda, Tomohiro, Dan, Yukihiko, Koyabu, Noriko, Ieiri, Ichiro, Otsubo, Kenji, Higuchi, Shun, Ohtani, Hisakazu, Sawada, Yasufumi

“…We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy…”
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Polymorphism of MDR1 Gene in Healthy Japanese Subjects： A Novel SNP with an Amino Acid Substitution (Glu108Lys) by Tomohiro HONDA, Yukihiko DAN, Noriko KOYABU, Ichiro IEIRI, Kenji OTSUBO, Shun HIGUCHI, Hisakazu OHTANI, Yasufumi SAWADA

“…We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy…”
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Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus by Dan, Yukihiko, Ohta, Yutaka, Tsuchimoto, Daisuke, Ohno, Mizuki, Ide, Yasuhito, Sami, Manabu, Kanda, Tomomasa, Sakumi, Kunihiko, Nakabeppu, Yusaku

“…A second class II AP endonuclease, APEX2, possesses strong 3′–5′ exonuclease and 3′-phosphodiesterase activities but only very weak AP-endonuclease activity…”
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Distribution of domperidone into the rat brain is increased by brain ischaemia or treatment with the P-glycoprotein inhibitor verapamil by Dan, Yukihiko, Murakami, Hideyasu, Koyabu, Noriko, Ohtani, Hisakazu, Sawada, Yasufumi

“…Domperidone (DOM), a peripheral dopamine D2 receptor antagonist, is a substrate of P‐glycoprotein (P‐gp). Therefore, the transport of DOM into the brain may be…”
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Relationship between MDR-1 polymorphisms and blood-brain barrier permeability of fexofenadine in human brain in vivo by Manabu Tashiro, Masayuki Tsujimoto, Yukihiko Dan, Motohisa Kato, Eiko Sakurai, Hisakazu Ohtani, Masatoshi Itoh, Yasufumi Sawada, Kazuhiko Yanai

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Potentiation of domperidone-induced catalepsy by a P-glycoprotein inhibitor, cyclosporin A by Tsujikawa, Kenji, Dan, Yukihiko, Nogawa, Kiyoko, Sato, Hitoshi, Yamada, Yasuhiko, Murakami, Hideyasu, Ohtani, Hisakazu, Sawada, Yasufumi, Iga, Tatsuji

“…The distribution of domperidone (DOM), a peripheral dopamine D2 receptor antagonist, to the brain is restricted by P‐glycoprotein (P‐gp) at the blood–brain…”
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