Search Results - "Dan, R."

The microbiota in adaptive immune homeostasis and disease by Honda, Kenya, Littman, Dan R.

“…In the mucosa, the immune system's T cells and B cells have position-specific phenotypes and functions that are influenced by the microbiota. These cells play…”
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Releasing the Brakes on Cancer Immunotherapy by Littman, Dan R.

“…This year’s Lasker∼DeBakey Clinical Research Award goes to James Allison for discovering that antibody blockade of the T cell molecule CTLA-4 unleashes the…”
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Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor by Parkhurst, Christopher N., Yang, Guang, Ninan, Ipe, Savas, Jeffrey N., Yates, John R., Lafaille, Juan J., Hempstead, Barbara L., Littman, Dan R., Gan, Wen-Biao

“…Microglia are the resident macrophages of the CNS, and their functions have been extensively studied in various brain pathologies. The physiological roles of…”
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Feeding-dependent VIP neuron–ILC3 circuit regulates the intestinal barrier by Talbot, Jhimmy, Hahn, Paul, Kroehling, Lina, Nguyen, Henry, Li, Dayi, Littman, Dan R.

“…The intestinal mucosa serves both as a conduit for the uptake of food-derived nutrients and microbiome-derived metabolites, and as a barrier that prevents…”
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Interactions Between the Microbiota and the Immune System by Hooper, Lora V., Littman, Dan R., Macpherson, Andrew J.

“…The large numbers of microorganisms that inhabit mammalian body surfaces have a highly coevolved relationship with the immune system. Although many of these…”
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Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses by Littman, Dan R., Pamer, Eric G.

“…The commensal microbiota that inhabit different parts of the gastrointestinal (GI) tract have been shaped by coevolution with the host species. The symbiotic…”
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The Microbiome in Infectious Disease and Inflammation by Honda, Kenya, Littman, Dan R

“…The mammalian alimentary tract harbors hundreds of species of commensal microorganisms (microbiota) that intimately interact with the host and provide it with…”
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Automating creativity assessment with SemDis: An open platform for computing semantic distance by Beaty, Roger E., Johnson, Dan R.

“…Creativity research requires assessing the quality of ideas and products. In practice, conducting creativity research often involves asking several human…”
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A Validated Regulatory Network for Th17 Cell Specification by Ciofani, Maria, Madar, Aviv, Galan, Carolina, Sellars, MacLean, Mace, Kieran, Pauli, Florencia, Agarwal, Ashish, Huang, Wendy, Parkurst, Christopher N., Muratet, Michael, Newberry, Kim M., Meadows, Sarah, Greenfield, Alex, Yang, Yi, Jain, Preti, Kirigin, Francis K., Birchmeier, Carmen, Wagner, Erwin F., Murphy, Kenneth M., Myers, Richard M., Bonneau, Richard, Littman, Dan R.

“…Th17 cells have critical roles in mucosal defense and are major contributors to inflammatory disease. Their differentiation requires the nuclear hormone…”
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Transportation into a story increases empathy, prosocial behavior, and perceptual bias toward fearful expressions by Johnson, Dan R.

“…► The influence of reading fiction on empathy, perception, and behavior is examined. ► Reading fiction increased state empathy while controlling for trait…”
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The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt by Manel, Nicolas, Unutmaz, Derya, Littman, Dan R

“…T H -17 cells are interleukin 17 (IL-17)–secreting CD4 + T helper cells involved in autoimmune disease and mucosal immunity. In naive CD4 + T cells from mice,…”
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TH17 cell heterogeneity and its role in tissue inflammation by Schnell, Alexandra, Littman, Dan R., Kuchroo, Vijay K.

“…Since their discovery almost two decades ago, interleukin-17-producing CD4 + T cells (T H 17 cells) have been implicated in the pathogenesis of multiple…”
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Sparse and compositionally robust inference of microbial ecological networks by Kurtz, Zachary D, Müller, Christian L, Miraldi, Emily R, Littman, Dan R, Blaser, Martin J, Bonneau, Richard A

“…16S ribosomal RNA (rRNA) gene and other environmental sequencing techniques provide snapshots of microbial communities, revealing phylogeny and the abundances…”
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Should Primary Care Physicians Be Managing Hypertension? by Berlowitz, Dan R

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An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses by Sano, Teruyuki, Huang, Wendy, Hall, Jason A., Yang, Yi, Chen, Alessandra, Gavzy, Samuel J., Lee, June-Yong, Ziel, Joshua W., Miraldi, Emily R., Domingos, Ana I., Bonneau, Richard, Littman, Dan R.

“…RORγt+ Th17 cells are important for mucosal defenses but also contribute to autoimmune disease. They accumulate in the intestine in response to microbiota and…”
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The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring by Choi, Gloria B., Yim, Yeong S., Wong, Helen, Kim, Sangdoo, Kim, Hyunju, Kim, Sangwon V., Hoeffer, Charles A., Littman, Dan R., Huh, Jun R.

“…Viral infection during pregnancy has been correlated with increased frequency of autism spectrum disorder (ASD) in offspring. This observation has been modeled…”
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Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense by Kinnebrew, Melissa A., Buffie, Charlie G., Diehl, Gretchen E., Zenewicz, Lauren A., Leiner, Ingrid, Hohl, Tobias M., Flavell, Richard A., Littman, Dan R., Pamer, Eric G.

“…Microbial penetration of the intestinal epithelial barrier triggers inflammatory responses that include induction of the bactericidal C-type lectin RegIIIγ…”
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Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring by Kim, Sangdoo, Kim, Hyunju, Yim, Yeong Shin, Ha, Soyoung, Atarashi, Koji, Tan, Tze Guan, Longman, Randy S., Honda, Kenya, Littman, Dan R., Choi, Gloria B., Huh, Jun R.

“…Maternal immune activation (MIA)-mediated abnormal behavioural phenotypes require defined gut commensal bacteria for the induction of IL-17-producing T helper…”
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Antigen-presenting cells as specialized drivers of intestinal T cell functions by Kedmi, Ranit, Littman, Dan R

“…The immune system recognizes a multitude of innocuous antigens from food and intestinal commensal microbes toward which it orchestrates appropriate,…”
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Th17 and Regulatory T Cells in Mediating and Restraining Inflammation by Littman, Dan R., Rudensky, Alexander Y.

“…The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential…”
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