Search Results - "Damuka, Naresh"

[18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates by Damuka, Naresh, Bashetti, Nagaraju, Mintz, Akiva, Bansode, Avinash H., Miller, Mack, Krizan, Ivan, Furdui, Cristina, Bhoopal, Bhuvanachandra, Gollapelli, Krishna Kumar, Shanmukha Kumar, JV, Deep, Gagan, Dugan, Greg, Cline, Mark, Solingapuram Sai, Kiran Kumar

“…Over production of reactive oxygen species (ROS) caused by altered redox regulation of signaling pathways is common in many types of cancers. While PET imaging…”
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Binding Parameters of [ 11 C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents by Bansode, Avinash H, Bhoopal, Bhuvanachandra, Gollapelli, Krishna Kumar, Damuka, Naresh, Krizan, Ivan, Miller, Mack, Craft, Suzanne, Mintz, Akiva, Solingapuram Sai, Kiran Kumar

“…Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies,…”
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Effect of ethanol and cocaine on [11C]MPC-6827 uptake in SH-SY5Y cells by Damuka, Naresh, Orr, Miranda, Czoty, Paul W., Weiner, Jeffrey L., Martin, Thomas J., Nader, Michael A., Bansode, Avinash H., Liyana Pathirannahel, Buddhika S., Mintz, Akiva, Macauley, Shannon L., Craft, Suzanne, Solingapuram Sai, Kiran Kumar

“…Microtubules (MTs) are structural units in the cytoskeleton. In brain cells they are responsible for axonal transport, information processing, and signaling…”
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PET Imaging of [ 11 C]MPC-6827, a Microtubule-Based Radiotracer in Non-Human Primate Brains by Damuka, Naresh, Czoty, Paul W, Davis, Ashley T, Nader, Michael A, Nader, Susan H, Craft, Suzanne, Macauley, Shannon L, Galbo, Lindsey K, Epperly, Phillip M, Whitlow, Christopher T, Davenport, April T, Martin, Thomas J, Daunais, James B, Mintz, Akiva, Sai, Kiran Kumar Solingapuram

“…Dysregulation of microtubules is commonly associated with several psychiatric and neurological disorders, including addiction and Alzheimer's disease. Imaging…”
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Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model by Damuka, Naresh, Orr, Miranda E., Bansode, Avinash H., Krizan, Ivan, Miller, Mack, Lee, Jillian, Macauley, Shannon L., Whitlow, Christopher T., Mintz, Akiva, Craft, Suzanne, Solingapuram Sai, Kiran Kumar

“…Background Microtubules (MTs) are critical for cell structure, function, and survival. MT instability may contribute to Alzheimer’s disease (AD) pathogenesis…”
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Dual PET imaging of microtubule destabilization and synaptic integrity in a mouse model of AD by Damuka, Naresh

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Initial Evaluations of the Microtubule-Based PET Radiotracer, [ 11 C]MPC-6827 in a Rodent Model of Cocaine Abuse by Damuka, Naresh, Martin, Thomas J, Bansode, Avinash H, Krizan, Ivan, Martin, Conner W, Miller, Mack, Whitlow, Christopher T, Nader, Michael A, Solingapuram Sai, Kiran Kumar

“…Microtubules (MTs) are structural units made of α and β tubulin subunits in the cytoskeleton responsible for axonal transport, information processing, and…”
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Method to Development of PET Radiopharmaceutical for Cancer Imaging by Damuka, Naresh, Solingapuram Sai, Kiran Kumar

“…The increasing number of different novel positron emission tomography (PET) radiopharmaceuticals poses challenges for their manufacturing procedures at…”
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Exploratory Dual PET imaging of 18F fluorodeoxyglucose and 11Cacetoacetate in type 2 diabetic nonhuman primates by Krizan, Ivan, Solingapuram Sai, Kiran K, Damuka, Naresh, Macauley, Shannon L, Maria Thurman, Bernetta, Long, Masha, Kavanagh, Kylie

“…Despite recent advancements in imaging (amyloid-PET & tau-PET) and fluid (Aβ42/Aβ40 & Aβ42/ptau) biomarkers, the current standard for in vivo assessment of AD,…”
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PET Use in Cancer Diagnosis, Treatment, and Prognosis by Damuka, Naresh, Dodda, Meghana, Solingapuram Sai, Kiran Kumar

“…Tumorigenesis is a multistep process marked by variations in numerous metabolic pathways that affect cellular architectures and functions. Cancer cells…”
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Exploratory Dual PET imaging of [18F] fluorodeoxyglucose and [11C]acetoacetate in type 2 diabetic nonhuman primates by Krizan, Ivan, Solingapuram Sai, Kiran K., Damuka, Naresh, Macauley, Shannon L., Maria Thurman, Bernetta, Long, Masha, Kavanagh, Kylie

“…Dual PET imaging with [11C]AcAc and [18F]FDG in brains of diabetic monkeys show relationships between glycemic control and Alzheimer’s disease biomarkers in…”
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Dual PET imaging of microtubules and synaptic density in a mouse model of Alzheimer’s Disease by Damuka, Naresh, Bansode, Avinash, Krizan, Ivan, Gollepalli, Krishna Kumar, Miller, Mack, Bhoopal, Bhuvanachandra, Whitlow, Christopher T., Lockhart, Samuel N., Craft, Suzanne, Sai, Kiran K Solingapuram

“…Background While microtubule (MT)‐destabilization and synaptic loss hallmark AD pathological events, no study has systematically quantified their in vivo…”
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Dual PET imaging of microtubules and synaptic density in a mouse model of Alzheimer’s Disease by Damuka, Naresh, Bansode, Avinash, Krizan, Ivan, Gollepalli, Krishna Kumar, Miller, Mack, Bhoopal, Bhuvanachandra, Whitlow, Christopher T., Lockhart, Samuel N., Craft, Suzanne, Sai, Kiran K Solingapuram

“…Background While microtubule (MT)‐destabilization and synaptic loss hallmark AD pathological events, no study has systematically quantified their in vivo…”
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[11C]MPC‐6827, a microtubule‐based PET imaging tracer: A potential early imaging biomarker for AD and other ADRDs by Sai, Kiran Solingapuram, Damuka, Naresh, Mintz, Akiva, Whitlow, Christopher T., Craft, Suzanne, Macauley‐Rambach, Shannon

“…Background Loss of microtubule (MT) network and impairment of MT function are considered to be part of the pathophysiology of several CNS disorders, including…”
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[ 11 C]MPC‐6827: A microtubule‐based pet imaging tracer for AD and related dementias: Neuroimaging / animal imaging by Macauley‐Rambach, Shannon, Damuka, Naresh, Whitlow, Christopher T., Mintz, Akiva, Craft, Suzanne, Sai, Kiran Solingapuram

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[11C]MPC‐6827, a microtubule‐based PET imaging tracer: A potential early imaging biomarker for AD and other ADRDs: Molecular imaging of novel biomarkers for neurodegeneration and ADRD by Sai, Kiran Solingapuram, Damuka, Naresh, Mintz, Akiva, Whitlow, Christopher T., Craft, Suzanne, Macauley‐Rambach, Shannon

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[11C]MPC‐6827: A microtubule‐based pet imaging tracer for AD and related dementias by Macauley‐Rambach, Shannon, Damuka, Naresh, Whitlow, Christopher T., Mintz, Akiva, Craft, Suzanne, Sai, Kiran Solingapuram

“…Background Loss of microtubule (MT) network and impairment of MT function are considered to be part of pathophysiology of several CNS disorders, including AD,…”
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MedPServer: A database for identification of therapeutic targets and novel leads pertaining to natural products by Potshangbam, Angamba Meetei, Polavarapu, Raja, Rathore, Ravindranath Singh, Naresh, Damuka, Prabhu, Nagu Prakash, Potshangbam, Nongdam, Kumar, Pravind, Vindal, Vaibhav

“…Natural products have been the source of treatment for various human diseases from time immemorial. Interests in natural product‐based scaffolds for the…”
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First GPR119 PET Imaging Ligand: Synthesis, Radiochemistry, and Preliminary Evaluations by Bansode, Avinash H., Damuka, Naresh, Bashetti, Nagaraju, Gollapelli, Krishna Kumar, Krizan, Ivan, Bhoopal, Bhuvanachandra, Miller, Mack, JV, Shanmukha Kumar, Whitlow, Christopher T., McClain, Donald, Ma, Tao, Jorgensen, Matthew J., Solingapuram Sai, Kiran Kumar

“…G-protein-coupled receptor 119 (GPR119) has emerged as a promising target for treating type 2 diabetes mellitus. Activating GPR119 improves glucose…”
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Discovery of dual cation-π inhibitors of acetylcholinesterase: design, synthesis and biological evaluation by Damuka, Naresh, Kammari, Kurumurthy, Potshangbam, Angamba Meetei, Rathore, Ravindranath Singh, Kondapi, Anand K, Vindal, Vaibhav

“…Alzheimer's disease (AD) is a widespread dementia-related disease affecting mankind worldwide. A cholinergic hypothesis is considered the most effective target…”
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