Search Results - "Damsky, Caroline H"

FAK integrates growth-factor and integrin signals to promote cell migration by Schlaepfer, David D, Sieg, David J, Hauck, Christof R, Ilic, Dusko, Klingbeil, Candice K, Schaefer, Erik, Damsky, Caroline H

“…Here we show that cells lacking focal adhesion kinase (FAK) are refractory to motility signals from platelet-derived and epidermal growth factors (PDGF and EGF…”
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Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration by Kim, Jae-Beom, Leucht, Philipp, Luppen, Cynthia A, Park, Yu Jin, Beggs, Hilary E, Damsky, Caroline H, Helms, Jill A

“…Abstract Integrins link the inside of a cell with its outside environment and in doing so regulate a wide variety of cell behaviors. Integrins are well known…”
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Plasma Membrane-Associated pY397FAK Is a Marker of Cytotrophoblast Invasion in Vivo and in Vitro by Ilić, Duško, Genbačev, Olga, Jin, Fang, Caceres, Eduardo, Almeida, Eduardo A.C., Bellingard-Dubouchaud, Valérie, Schaefer, Erik M., Damsky, Caroline H., Fisher, Susan J.

“…During human pregnancy specialized placental cells of fetal origin, termed cytotrophoblasts, invade the uterus and its blood vessels. This tumor-like process…”
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Integrin signaling: it's where the action is by Damsky, Caroline H, Ilić, Duško

“…Recent advances highlight a critical role for integrin receptors for extracellular matrix in determining where in cells critical signals are transduced…”
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Oxygen regulates human cytotrophoblast differentiation and invasion: implications for endovascular invasion in normal pregnancy and in pre-eclampsia by Zhou, Yan, Genbacev, Olga, Damsky, Caroline H, Fisher, Susan J

“…This review article focuses on the unique process by which the human placenta normally forms and how changes in this process can lead to serious pregnancy…”
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Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors by Damsky, Caroline H, Fisher, Susan J

“…During early development, a subset of fetal (placental) cytotrophoblasts exhibits tumor-like behavior and invades the uterus. To access a supply of maternal…”
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Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-Mediated Apoptosis by Ilić, Duško, Eduardo A. C. Almeida, Schlaepfer, David D., Dazin, Paul, Aizawa, Shinichi, Damsky, Caroline H.

“…In many malignant cells, both the anchorage requirement for survival and the function of the p53 tumor suppressor gene are subverted. These effects are…”
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Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information by Damsky, C H, Werb, Z

“…Adhesion receptors allow cells to interact with a dynamic and information-rich environment of extracellular matrix molecules. The integrin family of adhesion…”
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Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK− cell migration by Sieg, David J., Ilić, Duško, Jones, K.C., Damsky, Caroline H., Hunter, Tony, Schlaepfer, David D.

“…The focal adhesion kinase (FAK) protein‐tyrosine kinase (PTK) links transmembrane integrin receptors to intracellular signaling pathways. We show that…”
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Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro by Moursi, A. M., Globus, R. K., Damsky, C. H.

“…We previously showed that anti-fibronectin antibodies or soluble fibronectin fragments containing the central cell-binding domain inhibit formation of…”
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Collagen Integrin Receptors Regulate Early Osteoblast Differentiation Induced by BMP‐2 by Jikko, Akitoshi, Harris, Stephen E., Chen, Di, Mendrick, Donna L., Damsky, Caroline H.

“…Studies in several cell types indicate that the actions of integrin receptors for extracellular matrix and receptors for growth factors are synergistic in…”
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Focal Adhesion Kinase Is Required for Blood Vessel Morphogenesis by Ilic, Dusko, Kovacic, Branka, McDonagh, Susan, Jin, Fang, Baumbusch, Clark, Gardner, David G, Damsky, Caroline H

“…ABSTRACT—The nonreceptor tyrosine kinase focal adhesion kinase (FAK) is a point of convergence for signals from extracellular matrix, soluble factors, and…”
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FAK promotes organization of fibronectin matrix and fibrillar adhesions by Ilić, Dusko, Kovacic, Branka, Johkura, Kohei, Schlaepfer, David D, Tomasević, Nenad, Han, Qin, Kim, Jae-Beom, Howerton, Kyle, Baumbusch, Clark, Ogiwara, Naoko, Streblow, Daniel N, Nelson, Jay A, Dazin, Paul, Shino, Yuji, Sasaki, Katsunori, Damsky, Caroline H

“…Targeted disruption of the focal adhesion kinase (FAK) gene in mice is lethal at embryonic day 8.5 (E8.5). Vascular defects in FAK-/- mice result from the…”
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Focal adhesion kinase: at the crossroads of signal transduction by Ilić, D, Damsky, C H, Yamamoto, T

“…Morphogenetic processes during development, including cell migration, depend on signals from both the extracellular matrix (ECM) and soluble signaling factors…”
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Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages by Suen, P W, Ilic, D, Caveggion, E, Berton, G, Damsky, C H, Lowell, C A

“…Integrin-mediated adhesion of monocytes and macrophages initiates a signal transduction pathway that leads to actin cytoskeletal reorganization, cell migration…”
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Integrin switching regulates normal trophoblast invasion by Damsky, C H, Librach, C, Lim, K H, Fitzgerald, M L, McMaster, M T, Janatpour, M, Zhou, Y, Logan, S K, Fisher, S J

“…Cells invade extracellular matrices in a regulated manner at specific times and places during normal development. A dramatic example is trophoblast invasion of…”
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Fibronectin regulates calvarial osteoblast differentiation by Moursi, A. M., Damsky, C. H., Lull, J., Zimmerman, D., Doty, S. B., Aota, S., Globus, R. K.

“…The secretion of fibronectin by differentiating osteoblasts and its accumulation at sites of osteogenesis suggest that fibronectin participates in bone…”
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Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy by Kovacic-Milivojević, B, Roediger, F, Almeida, E A, Damsky, C H, Gardner, D G, Ilić, D

“…Hypertrophic terminally differentiated cardiac myocytes show increased sarcomeric organization and altered gene expression. Previously, we established a role…”
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Components of the Nuclear Signaling Cascade That Regulate Collagenase Gene Expression in Response to Integrin-Derived Signals by Tremble, Patrice, Damsky, Caroline H., Werb, Zena

“…We have shown previously that the expression of collagenase is upregulated in rabbit synovial fibroblasts cultured on a substrate of antibody to the α 5 chain…”
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The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak by BURDSAL, C. A, DAMSKY, C. H, PEDERSEN, R. A

“…We have examined the role of cell-cell and cell-extracellular matrix (ECM) interactions during mesoderm differentiation and migration at the primitive streak…”
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