Search Results - "Damsker, J M"

The effects of aerobic training and age on plasma sICAM-1 by Many, G M, Jenkins, N T, Witkowski, S, Damsker, J M, Hagberg, J

“…Chronic low-grade systemic inflammation plays a role in the development of cardiovascular (CV) disease. Habitual endurance exercise training reduces the risk…”
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Pharmacologically-induced mitotic synchrony in airway epithelial cells as a mechanism of action of anti-inflammatory drugs by Freishtat, R J, Nino, G, Tsegaye, Y, Alcala, S E, Benton, A S, Watson, A M, Reeves, E K M, Haider, S K, Damsker, J M

“…Mitotic synchrony is the synchronous progression of a population of cells through the cell cycle and is characteristic of non-diseased airway epithelial cells…”
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A107 THE LUNG'S SILVER LINING: AIRWAY AND ALVEOLAR EPITHELIAL BIOLOGY: Repression Of Muc5ac Gene Expression In Human Lung Epithelial Cells By Classical And Dissociative Steroids by Garvin, L M, Chen, Y, Jones, T, Damsker, J M, Rose, M

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B38 UPDATE IN ADULT CYSTIC FIBROSIS: Efficacy Of A Dissociative Steroid, Vbp15, In Reducing The Increased Mucin Burden In Cystic Fibrosis Lung Epithelial Cells by Garvin, L M, Peters-Hall, J, Brown, K J, Tomney, A, Jones, T, Chen, Y, Damsker, J M, Rose, M

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Phase 1 trial of vamorolone, a first-in-class steroid, shows improvements in side effects via biomarkers bridged to clinical outcomes by Hoffman, Eric P., Riddle, Valerie, Siegler, Maxime A., Dickerson, Daniel, Backonja, Miroslav, Kramer, William G., Nagaraju, Kanneboyina, Gordish-Dressman, Heather, Damsker, Jesse M., McCall, John M.

“…•Vamorolone (VBP15) is a steroidal drug that has shown dissociative properties.•The X-ray crystal structure of vamorolone is presented.•In a Phase 1 clinical…”
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P22 ADME properties of vamorolone, a first-in-class dissociative steroidal anti-inflammatory drug by Damsker, JM, Piyis, Y, Peña, LA, McCall, JM

“…BackgroundVamorolone is a first-in-class dissociative steroidal drug currently in Phase 2b/3 clinical trials in four to seven-year old boys with Duchenne…”
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Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug by Conklin, Laurie S., Damsker, Jesse M., Hoffman, Eric P., Jusko, William J., Mavroudis, Panteleimon D., Schwartz, Benjamin D., Mengle-Gaw, Laurel J., Smith, Edward C., Mah, Jean K., Guglieri, Michela, Nevo, Yoram, Kuntz, Nancy, McDonald, Craig M., Tulinius, Mar, Ryan, Monique M., Webster, Richard, Castro, Diana, Finkel, Richard S., Smith, Andrea L., Morgenroth, Lauren P., Arrieta, Adrienne, Shimony, Maya, Jaros, Mark, Shale, Phil, McCall, John M., Hathout, Yetrib, Nagaraju, Kanneboyina, van den Anker, John, Ward, Leanne M., Ahmet, Alexandra, Cornish, Michaelyn R., Clemens, Paula R.

“…[Display omitted] We report a first-in-patient study of vamorolone, a first-in-class dissociative steroidal anti-inflammatory drug, in Duchenne muscular…”
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Muscle miRNAome shows suppression of chronic inflammatory miRNAs with both prednisone and vamorolone by Fiorillo, Alyson A, Tully, Christopher B, Damsker, Jesse M, Nagaraju, Kanneboyina, Hoffman, Eric P, Heier, Christopher R

“…Corticosteroids are highly prescribed and effective anti-inflammatory drugs but the burden of side effects with chronic use significantly detracts from patient…”
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VBP15, a novel anti‐inflammatory and membrane‐stabilizer, improves muscular dystrophy without side effects by Heier, Christopher R., Damsker, Jesse M., Yu, Qing, Dillingham, Blythe C., Huynh, Tony, Van der Meulen, Jack H., Sali, Arpana, Miller, Brittany K., Phadke, Aditi, Scheffer, Luana, Quinn, James, Tatem, Kathleen, Jordan, Sarah, Dadgar, Sherry, Rodriguez, Olga C., Albanese, Chris, Calhoun, Michael, Gordish‐Dressman, Heather, Jaiswal, Jyoti K., Connor, Edward M., McCall, John M., Hoffman, Eric P., Reeves, Erica K. M., Nagaraju, Kanneboyina

“…Absence of dystrophin makes skeletal muscle more susceptible to injury, resulting in breaches of the plasma membrane and chronic inflammation in Duchenne…”
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VBP15: Preclinical characterization of a novel anti-inflammatory delta 9,11 steroid by Reeves, Erica K.M, Hoffman, Eric P, Nagaraju, Kanneboyina, Damsker, Jesse M, McCall, John M

“…Δ9,11 modifications of glucocorticoids (21-aminosteroids) have been developed as drugs for protection against cell damage (lipid peroxidation; lazaroids) and…”
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A novel dissociative steroid VBP15 reduces MUC5AC gene expression in airway epithelial cells but lacks the GRE mediated transcriptional properties of dexamethasone by Garvin, Lindsay M, Chen, Yajun, Damsker, Jesse M, Rose, Mary C

“…Abstract Overproduction of secretory mucins contributes to morbidity/mortality in inflammatory lung diseases. Inflammatory mediators directly increase…”
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VBP15, a novel dissociative steroid compound, reduces NFκB-induced expression of inflammatory cytokines in vitro and symptoms of murine trinitrobenzene sulfonic acid-induced colitis by Damsker, Jesse M., Conklin, Laurie S., Sadri, Soheil, Dillingham, Blythe C., Panchapakesan, Karuna, Heier, Christopher R., McCall, John M., Sandler, Anthony D.

“…Objective and design The goal of this study was to assess the capacity of VBP15, a dissociative steroidal compound, to reduce pro-inflammatory cytokine…”
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VBP15, a Novel Anti-Inflammatory, is Effective at Reducing the Severity of Murine Experimental Autoimmune Encephalomyelitis by Dillingham, Blythe C., Knoblach, Susan M., Many, Gina M., Harmon, Brennan T., Mullen, Amanda M., Heier, Christopher R., Bello, Luca, McCall, John M., Hoffman, Eric P., Connor, Edward M., Nagaraju, Kanneboyina, Reeves, Erica K. M., Damsker, Jesse M.

“…Multiple sclerosis is a chronic disease of the central nervous system characterized by an autoimmune inflammatory reaction that leads to axonal demyelination…”
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VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice by Damsker, Jesse M, Dillingham, Blythe C, Rose, Mary C, Balsley, Molly A, Heier, Christopher R, Watson, Alan M, Stemmy, Erik J, Jurjus, Roslyn A, Huynh, Tony, Tatem, Kathleen, Uaesoontrachoon, Kitipong, Berry, Dana M, Benton, Angela S, Freishtat, Robert J, Hoffman, Eric P, McCall, John M, Gordish-Dressman, Heather, Constant, Stephanie L, Reeves, Erica K M, Nagaraju, Kanneboyina

“…Asthma is a chronic inflammatory condition of the lower respiratory tract associated with airway hyperreactivity and mucus obstruction in which a majority of…”
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Preferential chemotaxis of activated human CD4 super(+) T cells by extracellular cyclophilin A by Damsker, JM, Bukrinsky, MI, Constant, S L

“…The recruitment and trafficking of leukocytes are essential aspects of the inflammatory process. Although chemokines are thought to be the main regulators of…”
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