Search Results - "Damon, I."

Humoral Immunity to Smallpox Vaccines and Monkeypox Virus Challenge: Proteomic Assessment and Clinical Correlations by Townsend, M B, Keckler, M S, Patel, N, Davies, D H, Felgner, P, Damon, I K, Karem, K L

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Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1 by Tardif, Keith D, Rogers, Aaron, Cassiano, Jared, Roth, Bruce L, Cimbora, Daniel M, McKinnon, Rena, Peterson, Ashley, Douce, Thomas B, Robinson, Rosann, Dorweiler, Irene, Davis, Thaylon, Hess, Mark A, Ostanin, Kirill, Papac, Damon I, Baichwal, Vijay, McAlexander, Ian, Willardsen, J Adam, Saunders, Michael, Christophe, Hoarau, Kumar, D Vijay, Wettstein, Daniel A, Carlson, Robert O, Williams, Brandi L

“…Mps1 is a dual specificity protein kinase that is essential for the bipolar attachment of chromosomes to the mitotic spindle and for maintaining the spindle…”
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Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys by Jones, Andrew J.S, Papac, Damon I, Chin, Edward H, Keck, Rodney, Baughman, Sharon A, Lin, Yvonne S, Kneer, Johannes, Battersby, John E

“…To understand how the carbohydrate moieties of a recombinant glycoprotein affected its pharmacokinetic (PK) properties, the glycan distribution was directly…”
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Establishment of the Black-Tailed Prairie Dog (Cynomys ludovicianus) as a Novel Animal Model for Comparing Smallpox Vaccines Administered Preexposure in both High- and Low-Dose Monkeypox Virus Challenges by KECKLER, M. S, CARROLL, D. S, KAREM, K. L, DAMON, I. K, GALLARDO-ROMERO, N. F, LASH, R. R, SALZER, J. S, WEISS, S. L, PATEL, N, CLEMMONS, C. J, SMITH, S. K, HUTSON, C. L

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Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors by Vijay Kumar, D., Hoarau, Christophe, Bursavich, Matthew, Slattum, Paul, Gerrish, David, Yager, Kraig, Saunders, Michael, Shenderovich, Mark, Roth, Bruce L., McKinnon, Rena, Chan, Ashley, Cimbora, Daniel M., Bradford, Chad, Reeves, Leslie, Patton, Scott, Papac, Damon I., Williams, Brandi L., Carlson, Robert O.

“…Efforts to optimize biological activity, novelty, selectivity and oral bioavailability of Mps1 inhibitors, from a purine based lead MPI-0479605, are described…”
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Safety and Immunogenicity of LC16m8, an Attenuated Smallpox Vaccine in Vaccinia-Naive Adults by Kennedy, Jeffrey S., Gurwith, Marc, Dekker, Cornelia L., Frey, Sharon E., Edwards, Kathryn M., Kenner, Julie, Lock, Michael, Empig, Cyril, Morikawa, Shigeru, Saijo, Masayuki, Yokote, Hiroyuki, Karem, Kevin, Damon, Inger, Perlroth, Mark, Greenberg, Richard N.

“…Introduction. LC16m8 is an attenuated cell culture-adapted Lister vaccinia smallpox vaccine missing the B5R protein and licensed for use in Japan. Methods. We…”
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Analysis of the Monkeypox Virus Genome by Shchelkunov, S.N., Totmenin, A.V., Safronov, P.F., Mikheev, M.V., Gutorov, V.V., Ryazankina, O.I., Petrov, N.A., Babkin, I.V., Uvarova, E.A., Sandakhchiev, L.S., Sisler, J.R., Esposito, J.J., Damon, I.K., Jahrling, P.B., Moss, B.

“…Monkeypox virus (MPV) belongs to the orthopoxvirus genus of the family Poxviridae, is endemic in parts of Africa, and causes a human disease that resembles…”
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Clinical Characteristics of Human Monkeypox, and Risk Factors for Severe Disease by Huhn, Gregory D., Bauer, Audrey M., Yorita, Krista, Graham, Mary Beth, Sejvar, James, Likos, Anna, Damon, Inger K., Reynolds, Mary G., Kuehnert, Matthew J.

“…Background. Human monkeypox is an emerging smallpox-like illness that was identified for the first time in the United States during an outbreak in 2003…”
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Surveillance of Parapoxvirus Among Ruminants in Virginia and Connecticut by Roess, A. A., McCollum, A. M., Gruszynski, K., Zhao, H., Davidson, W., Lafon, N., Engelmeyer, T., Moyer, B., Godfrey, C., Kilpatrick, H., Labonte, A., Murphy, J., Carroll, D. S., Li, Y., Damon, I. K.

“…Summary In 2008, two deer hunters in Virginia and Connecticut were infected with a unique strain of pseudocowpox virus, a parapoxvirus. To estimate the…”
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Clinical management and humoral immune responses to rabies post-exposure prophylaxis among three patients who received solid organs from a donor with rabies by Vora, N.M., Orciari, L.A., Niezgoda, M., Selvaggi, G., Stosor, V., Lyon III, G.M., Wallace, R.M., Gabel, J., Stanek, D.R., Jenkins, P., Shiferaw, M., Yager, P., Jackson, F., Hanlon, C.A., Damon, I., Blanton, J.D., Recuenco, S., Franka, R.

“…Background The rabies virus causes a fatal encephalitis and can be transmitted through organ transplantation. In 2013, a man developed rabies 18 months after…”
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Progressive Orf Virus Infection in a Patient with Lymphoma: Successful Treatment Using Imiquimod by Lederman, Edith R., Green, Gary M., DeGroot, Henry E., Dahl, Patricia, Goldman, Erinn, Greer, Patricia W., Li, Yu, Zhao, Hui, Paddock, Christopher D., Damon, Inger K.

“…Orf virus is a parapoxvirus that infects small ruminants worldwide. We present the case report of a 73-year-old woman with non-Hodgkins lymphoma who developed…”
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Mass spectrometry innovations in drug discovery and development by PAPAC, Damon I, SHAHROKH, Zahra

“…This review highlights the many roles mass spectrometry plays in the discovery and development of new therapeutics by both the pharmaceutical and the…”
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Training health workers for enhanced monkeypox surveillance, Democratic Republic of the Congo by Reynolds, M, Malekani, J, Damon, I, Monroe, B, Kabamba, J, Lushima, R. Shongo, Nguete, B, Karhemere, S, Pukuta, E, Tack, D, McCollum, A, Bass, J, Wemakoy, O

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Human monkeypox in the Kivus, a conflict region of The Democratic Republic of the Congo by McCollum, A, Nakazawa, Y, Ndongala, G. Mutombo, Pukuta, E, Karhemere, S, Lushima, R. Shongo, Ilunga, B. Kebela, Kabamba, J, Li, Y, Damon, I, Carroll, D, Reynolds, M, Malekani, J, Tamfum, J.-J. Muyembe

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Ocular complications associated with acute monkeypox virus infection, DRC by Hughes, C, McCollum, A, Pukuta, E, Karhemere, S, Nguete, B, Shongo Lushima, R, Kabamba, J, Balilo, M, Muyembe Tamfum, J.-J, Wemakoy, O, Malekani, J, Monroe, B, Damon, I, Reynolds, M

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Virulence differences between monkeypox virus isolates from West Africa and the Congo basin by Chen, Nanhai, Li, Guiyun, Liszewski, M. Kathryn, Atkinson, John P., Jahrling, Peter B., Feng, Zehua, Schriewer, Jill, Buck, Charles, Wang, Chunlin, Lefkowitz, Elliot J., Esposito, Joseph J., Harms, Tiara, Damon, Inger K., Roper, Rachel L., Upton, Chris, Buller, R. Mark L.

“…Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more…”
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Diagnosis of Bovine-Associated Parapoxvirus Infections in Humans: Molecular and Epidemiological Evidence by MacNeil, A., Lederman, E., Reynolds, M. G., Ragade, N. J., Talken, R., Friedman, D., Hall, W., Shwe, T., Li, Y., Zhao, H., Smith, S., Davidson, W., Hughes, C., Damon, I. K.

“…Summary Orf virus, pseudocowpox virus and bovine papular stomatitis virus, are parapoxviruses, associated with domestic ruminants, which are capable of causing…”
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Evaluation of Human-to-Human Transmission of Monkeypox from Infected Patients to Health Care Workers by Fleischauer, Aaron T., Kile, James C., Davidson, Molly, Fischer, Marc, Karem, Kevin L., Teclaw, Robert, Messersmith, Hans, Pontones, Pamela, Beard, Bradley A., Braden, Zachary H., Cono, Joanne, Sejvar, James J., Khan, Ali S., Damon, Inger, Kuehnert, Matthew J.

“…Background. In 2003, human monkeypox was first identified in the United States. The outbreak was associated with exposure to infected prairie dogs, but the…”
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Analysis of Acidic Oligosaccharides and Glycopeptides by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry by Papac, Damon I, Wong, Anissa, Jones, Andrew J. S

“…2,5-Dihydroxybenzoic acid (DHB) is the most commonly used matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF)…”
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Poxvirus viability and signatures in historical relics by McCollum, A, Li, Y, Wilkins, K, Davidson, W, Paddock, C, Karem, K, Reynolds, M, Damon, I

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