Search Results - "Damen, Carola W.N."

Enhanced lipid isomer separation in human plasma using reversed-phase UPLC with ion-mobility/high-resolution MS detection[S] by Damen, Carola W.N., Isaac, Giorgis, Langridge, James, Hankemeier, Thomas, Vreeken, Rob J.

“…An ultraperformance LC (UPLC) method for the separation of different lipid molecular species and lipid isomers using a stationary phase incorporating charged…”
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Malnourished Malawian patients presenting with large Wilms tumours have a decreased vincristine clearance rate by Israels, Trijn, Damen, Carola W.N, Cole, Michael, van Geloven, Nan, Boddy, Alan V, Caron, Huib N, Beijnen, Jos H, Molyneux, Elizabeth M, Veal, Gareth J

“…Abstract Introduction In developing countries, patients with a Wilms’ tumour often present late with a high degree of malnutrition and large tumours. We…”
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Matrix Effect Compensation in Small-Molecule Profiling for an LC–TOF Platform Using Multicomponent Postcolumn Infusion by González, Oskar, van Vliet, Michael, Damen, Carola W. N, van der Kloet, Frans M, Vreeken, Rob J, Hankemeier, Thomas

“…The possible presence of matrix effect is one of the main concerns in liquid chromatography–mass spectrometry (LC–MS)-driven bioanalysis due to its impact on…”
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Electrospray Ionization Quadrupole Ion-Mobility Time-of-Flight Mass Spectrometry as a Tool to Distinguish the Lot-to-Lot Heterogeneity in N-Glycosylation Profile of the Therapeutic Monoclonal Antibody Trastuzumab by Damen, Carola W.N., Chen, Weibin, Chakraborty, Asish B., van Oosterhout, Mike, Mazzeo, Jeffrey R., Gebler, John C., Schellens, Jan H.M., Rosing, Hilde, Beijnen, Jos H.

“…Monoclonal antibodies are typically glycosylated at asparagine residues in the Fc domain, and glycosylation heterogeneity at the Fc sites is well known. This…”
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Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma by Damen, Carola W.N., de Groot, Els R., Heij, Marianne, Boss, David S., Schellens, Jan H.M., Rosing, Hilde, Beijnen, Jos H., Aarden, Lucien A.

“…Trastuzumab, a humanized monoclonal antibody, is used for the treatment of breast cancer patients who overexpress the HER2 receptor. To optimize therapy,…”
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Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D by Damen, Carola W. N, Rosing, Hilde, Schellens, Jan H. M, Beijnen, Jos H

“…A sensitive, specific and efficient high-performance liquid chromatography-tandem mass spectrometry assay for the simultaneous determination of vincristine and…”
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P-glycoprotein, multidrug-resistance associated protein 2, Cyp3a, and carboxylesterase affect the oral availability and metabolism of vinorelbine by Lagas, Jurjen S, Damen, Carola W N, van Waterschoot, Robert A B, Iusuf, Dilek, Beijnen, Jos H, Schinkel, Alfred H

“…We investigated the interactions of the anticancer drug vinorelbine with drug efflux transporters and cytochrome P450 3A drug-metabolizing enzymes. Vinorelbine…”
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The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum by Damen, Carola W.N., Derissen, Ellen J.B., Schellens, Jan H.M., Rosing, Hilde, Beijnen, Jos H.

“…For the quantification of therapeutic monoclonal antibodies in biological specimens, enzyme-linked immunosorbent assay (ELISA) is the most widely used…”
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Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry by Damen, Carola W.N., Rosing, Hilde, Schellens, Jan H.M., Beijnen, Jos H.

“…The analytical possibilities of quantification of the intact monoclonal antibody trastuzumab by high-performance liquid chromatography coupled with…”
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The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry by Damen, Carola W.N., Speijer, Han, Hermens, Wim T., Schellens, Jan H.M., Rosing, Hilde, Beijnen, Jos H.

“…For the bioanalysis of therapeutic monoclonal antibodies in biological matrices, immunoassays—especially enzyme-linked immunosorbent assays (ELISAs)—are the…”
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Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem mass spectrometry by Damen, Carola W. N., Israëls, Trijn, Caron, Huib N., Schellens, Jan H.M., Rosing, Hilde, Beijnen, Jos H.

“…A sensitive, specific and efficient high‐performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) assay for the simultaneous determination of…”
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High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature by Damen, Carola W. N., Rosing, Hilde, Schellens, Jan H. M., Beijnen, Jos H.

“…The bioanalysis of vinca‐alkaloids has been investigated extensively. High‐performance liquid chromatography coupled to ultraviolet, fluorescence or…”
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The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry by Damen, Carola W. N., Lagas, Jurjen S., Rosing, Hilde, Schellens, Jan H. M., Beijnen, Jos H.

“…A sensitive, specific and efficient high‐performance liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of vinorelbine and…”
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A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry by Damen, Carola W.N., Rosing, Hilde, Tibben, Matthijs M., van Maanen, Maria J., Lagas, Jurjen S., Schinkel, Alfred H., Schellens, Jan H.M., Beijnen, Jos H.

“…A sensitive, specific and fast high-performance liquid chromatography/tandem mass spectrometry (HPLC–MS/MS) assay for the determination of vinorelbine in mouse…”
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