Search Results - "Dambrova, M"

Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels by Dambrova, M, Latkovskis, G, Kuka, J, Strele, I, Konrade, I, Grinberga, S, Hartmane, D, Pugovics, O, Erglis, A, Liepinsh, E

“…Recent studies have revealed strong associations between systemic trimethylamine N-oxide (TMAO) levels, atherosclerosis and cardiovascular risk. In addition,…”
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Risks and benefits of carnitine supplementation in diabetes by Dambrova, M, Liepinsh, E

“…L-carnitine is a very popular food supplement due to its safety profile, antioxidant-type activity and suggested effects on energy metabolism pathways…”
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The Differentiation of Skin Mesenchymal Stem Cells Towards a Schwann Cell Phenotype: Impact of Sigma-1 Receptor Activation by Saulite, L., Vavers, E., Zvejniece, L., Dambrova, M., Riekstina, U.

“…Neural crest stem cells (NCSCs) are the source of mature Schwann cells in the peripheral nervous system (PNS). The NCSC population resides in the bulge of hair…”
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Loop diuretics decrease the renal elimination rate and increase the plasma levels of trimethylamine‐N‐oxide by Latkovskis, G., Makarova, E., Mazule, M., Bondare, L., Hartmane, D., Cirule, H., Grinberga, S., Erglis, A., Liepinsh, E., Dambrova, M.

“…Aims Trimethylamine‐N‐oxide (TMAO) is a novel cardiovascular risk marker. We explored the association of commonly used cardiovascular medications with TMAO…”
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Inhibition of L‐carnitine biosynthesis and transport by methyl‐γ‐butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction by Liepinsh, E, Makrecka‐Kuka, M, Kuka, J, Vilskersts, R, Makarova, E, Cirule, H, Loza, E, Lola, D, Grinberga, S, Pugovics, O, Kalvins, I, Dambrova, M

“…Background and Purpose The important pathological consequences of ischaemic heart disease arise from the detrimental effects of the accumulation of long‐chain…”
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The cognition‐enhancing activity of E1R, a novel positive allosteric modulator of sigma‐1 receptors by Zvejniece, L, Vavers, E, Svalbe, B, Vilskersts, R, Domracheva, I, Vorona, M, Veinberg, G, Misane, I, Stonans, I, Kalvinsh, I, Dambrova, M

“…Background and Purpose Here, we describe the in vitro and in vivo effects of (4R,5S)‐2‐(5‐methyl‐2‐oxo‐4‐phenyl‐pyrrolidin‐1‐yl)‐acetamide (E1R), a novel…”
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Taregting acylcarnitine content in vascular tissue to attenuate development of atherosclerosis by Vilskersts, R, Kuka, J, Makrecka-Kuka, M, Volska, K, Dambrova, M, Liepinsh, E

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Improved Method for EPR Detection of DEPMPO-Superoxide Radicals by Liquid Nitrogen Freezing by Dambrova, M., Baumane, L., Kalvinsh, I., Wikberg, J.E.S.

“…5-Diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO) is frequently used as a spin trap for the measurement of superoxide by EPR spectrometry. However,…”
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GUANIDINES: FROM MOLECULE TO PRIMATE by Oliver, D.W., Dormehl, I.C., Wikberg, JES, Dambrova, M.

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In vivo measurements of the cerebral perfusion and cardiovascular effects of the novel guanidine ME10092 in the non-human primate, Papio ursinus by Oliver, D.W., Dormehl, I.C., Wikberg, J.E.S., Louw, W.K.A, Dambrova, M., van Gelder, A., Kilian, E., van Rensburg, E. Jansen

“…The novel guanidines N-(3,4-dimethoxy-2-chlorobenzylideneamino)-guanidine (ME 10092) and N-(3,4-dimethoxy-2-chlorobenzylideneamino)-N 1-hydroxyguanidine (PR5)…”
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P5331Trimethylamine-N-oxide levels are associated with increased insulin resistance by Latkovskis, G., Mazule, M., Bondare, L., Racicka, A., Makarova, E., Hartmane, D., Liepins, E., Konrade, I., Dambrova, M., Erglis, A.

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The difference spectrum of activity of synthetic interferon inductors by Bulgakova, V, Dambrova, M, Makarova, E, Vilskersts, R, Bevz, A, Prostyakov, I, Nadorov, S, Osipova, E

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PO-0927The Difference Spectrum Of Activity Of Synthetic Interferon Inductors by Bulgakova, V, Dambrova, M, Makarova, E, Vilskersts, R, Bevz, A, Prostyakov, I, Nadorov, S, Osipova, E

“…ObjectivesUntil now the stimulating effects of these interferonogens have been shown for type I and II IFNs, however the data regarding induction of type III…”
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PO-0927 The Difference Spectrum Of Activity Of Synthetic Interferon Inductors by Bulgakova, V, Dambrova, M, Makarova, E, Vilskersts, R, Bevz, A, Prostyakov, I, Nadorov, S, Osipova, E

“…ObjectivesUntil now the stimulating effects of these interferonogens have been shown for type I and II IFNs, however the data regarding induction of type III…”
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Inhibition of L-carnitine biosynthesis and transport by methyl-[gamma]-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction by Liepinsh, E, Makrecka-Kuka, M, Kuka, J, Vilskersts, R, Makarova, E, Cirule, H, Loza, E, Lola, D, Grinberga, S, Pugovics, O, Kalvins, I, Dambrova, M

“…Background and Purpose The important pathological consequences of ischaemic heart disease arise from the detrimental effects of the accumulation of long-chain…”
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Mildronate: Cardioprotective Action through Carnitine-Lowering Effect by Dambrova, Maija, Liepinsh, Edgars, Kalvinsh, Ivars

“…Mildronate [3-(2,2,2-trimethylhydrazinium)propionate dihydrate] ameliorates cardiac function during ischemia by modulating myocardial energy metabolism…”
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Carnitine as a marker of atherosclerosis and other risks of cardiovascular diseases by Dambrova, M, Makretskaia, M, Vilshkersts, R, Kuka, Ia, Liepin'sh, É

“…L-carnitine was first isolated from the extracts of muscle tissue in 1905 by the employees of the department of medicinal chemistry at Moscow University. Later…”
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Mildronate exerts acute anticonvulsant and antihypnotic effects by Zvejniece, Liga, Svalbe, Baiba, Makrecka, Marina, Liepinsh, Edgars, Kalvinsh, Ivars, Dambrova, Maija

“…The effects of mildronate [3-(2,2,2-trimethylhydrazinium) propionate], an inhibitor of L-carnitine biosynthesis and an anti-ischaemic drug, were examined in…”
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Novel methods for the synthesis of 2-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]-acetamide ((R)-phenotropil) by Vorona, M., Veinberg, G., Vikainis, S., Kuznetsov, E., Lebedev, A., Ponomarev, Yu, Chernobrovijs, A., Zvejniece, L., Dambrova, M.

“…Two novel methods have been developed for the preparation of 2-[(4 R )-2-oxo-4-phenylpyrrolidin-1-yl]acetamide (( R )-Phenotropil). In the first, n -butyl (3 R…”
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Novel methods for the synthesis of 2- by Vorona, M, Veinberg, G, Vikainis, S, Kuznetsov, E, Lebedev, A, Ponomarev, Yu, Chernobrovijs, A, Zvejniece, L, Dambrova, M

“…Two novel methods have been developed for the preparation of 2-[(4R)-2-oxo-4- phenylpyrrolidin-1-yl]acetamide ((R)-Phenotropil). In the first, n-butyl…”
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