Search Results - "Dambaya, Beatrice"
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Evaluation of HIV-1 capsid genetic variability and lenacapavir (GS-6207) drug resistance-associated mutations according to viral clades among drug-naive individuals
Published in Journal of antimicrobial chemotherapy (01-01-2023)“…Abstract Objectives We evaluated the HIV-1 capsid genetic variability and lenacapavir drug resistance-associated mutations (DRMs) among drug-naive individuals…”
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Baseline integrase drug resistance mutations and conserved regions across HIV-1 clades in Cameroon: implications for transition to dolutegravir in resource-limited settings
Published in Journal of antimicrobial chemotherapy (13-04-2021)“…Abstract Background Transition to dolutegravir-based regimens in resource-limited settings (RLS) requires prior understanding of HIV-1 integrase variants and…”
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HIV-1 subtype diversity and immuno-virological outcomes among adolescents failing antiretroviral therapy in Cameroon: A cohort study
Published in PloS one (25-10-2023)“…Objective We sought to evaluate the variability of HIV-1 and its effect on immuno-virological response among adolescents living with perinatally acquired HIV…”
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HIV-1 Gag gene mutations, treatment response and drug resistance to protease inhibitors: A systematic review and meta-analysis protocol
Published in PloS one (01-07-2021)“…Some mutations in the HIV-1 Gag gene are known to confer resistance to ritonavir-boosted protease inhibitors (PI/r), but their clinical implications remain…”
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High performance of integrase genotyping on diverse HIV-1 clades circulating in Cameroon: toward a successful transition to dolutegravir-based regimens in low and middle-income countries
Published in Diagnostic microbiology and infectious disease (01-02-2022)“…•Integrase genotyping is highly effective at the WHO-threshold of ≥1000 copies/mL;•Assay performance increases with viremia, reaching 84% at…”
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Laboratory Based Surveillance of HIV-1 Acquired Drug Resistance in Cameroon: Implications for Use of Tenofovir-Lamivudine-Dolutegravir (TLD) as Second- or Third-Line Regimens
Published in Viruses (01-08-2023)“…Increased HIV drug resistance (HIVDR) with antiretroviral therapy (ART) rollout may jeopardize therapeutic options, especially in this era of transition to…”
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Pre-Treatment HIV Drug Resistance and Genetic Diversity in Cameroon: Implications for First-Line Regimens
Published in Viruses (28-06-2023)“…The efficacy of first-line antiretroviral therapy (ART) may be hampered by the presence of HIV drug resistance (HIVDR). We described HIV-1 pre-treatment drug…”
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HLA A32 is associated to HIV acquisition while B44 and B53 are associated with protection against HIV acquisition in perinatally exposed infants
Published in BMC pediatrics (23-07-2019)“…Human leukocyte antigen (HLA) molecules play a key role in the cellular immune system. They may be determinants of mother-to-child transmission which is the…”
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Genotypic resistance testing improves antiretroviral treatment outcomes in a cohort of adolescents in Cameroon: Implications in the dolutegravir‑era
Published in Journal of public health in Africa (01-10-2023)“…Poor internet infrastructure limits the use of computer-based nursing process forms in rural areas. This study aimed to configure a computer‑based nursing…”
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HIV-1 integrase resistance associated mutations and the use of dolutegravir in Sub-Saharan Africa: a systematic review and meta-analysis protocol
Published in Systematic reviews (25-04-2020)“…Sub-Saharan Africa carries the greatest burden of HIV-infection with increasing drug resistance burden, which requires improved patient management and…”
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Maternal age, infant age, feeding options, single/multiple pregnancy, type of twin sets and mother-to-child transmission of HIV
Published in Journal of tropical pediatrics (1980) (01-06-2019)“…Some risk factors for mother-to-child transmission (MTCT) of HIV have been identified. To further reduce MTCT, other risk factors were evaluated. A…”
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HIV-1 integrase resistance associated mutations and the use of dolutegravir in Sub-Saharan Africa: A systematic review and meta-analysis
Published in PLOS global public health (2022)“…As sub-Saharan Africa (SSA) countries are transitioning to dolutegravir (DTG)-based ART, baseline data are required for optimal monitoring of therapeutic…”
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Detection of Gag C-terminal mutations among HIV-1 non-B subtypes in a subset of Cameroonian patients
Published in Scientific reports (26-01-2022)“…Response to ritonavir-boosted-protease inhibitors (PI/r)-based regimen is associated with some Gag mutations among HIV-1 B-clade. There is limited data on Gag…”
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HIV-1 drug resistance testing is essential for heavily-treated patients switching from first- to second-line regimens in resource-limited settings: evidence from routine clinical practice in Cameroon
Published in BMC infectious diseases (12-03-2019)“…With the phase-out of stavudine (d4T), change to first-line regimens with zidovudine (AZT) or tenofovir (TDF) in resource-limited settings (RLS) might increase…”
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Differential expression of Fas receptors (CD95) and Fas ligands (CD95L) in HIV infected and exposed uninfected children in Cameroon versus unexposed children
Published in The Pan African medical journal (2019)“…The number of HIV exposed uninfected (HEU) infants is increasing as vertical transmission is reducing. This subpopulation requires more investigations. This…”
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Implementation of HIV early infant diagnosis and HIV type 1 RNA viral load determination on dried blood spots in Cameroon: challenges and propositions
Published in AIDS research and human retroviruses (01-02-2012)“…The testing of dried blood spots (DBSs) for human immunodeficiency type 1 (HIV-1) proviral DNA by PCR is a technology that has proven to be particularly…”
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Host molecular factors and viral genotypes in the mother-to-child HIV-1 transmission in sub-Saharan Africa
Published in Journal of public health in Africa (03-07-2017)“…Maternal viral load and immune status, timing and route of delivery, viral subtype, and host genetics are known to influence the transmission, acquisition and…”
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HIV-1 genotypic profiling ensures effective response to third-line antiretroviral therapy in Cameroon
Published in Medicine (Baltimore) (02-06-2023)“…In order to limit the emergence of human immunodeficiency virus (HIV) drug resistance in a context of limited antiretroviral options, we sought to evaluate the…”
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Archiving of mutations in HIV‐1 cellular reservoirs among vertically infected adolescents is contingent with clinical stages and plasma viral load: Evidence from the EDCTP‐READY study
Published in HIV medicine (01-07-2022)“…Introduction Globally, HIV‐related adolescent deaths have increased about 50%, especially for those who are vertically infected. This could be driven by…”
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