DNA methylation epi-signature and biological age in attention deficit hyperactivity disorder patients

DNA methylation epi-signature and biological age in attention deficit hyperactivity disorder patients

Attention Deficit/Hyperactivity Disorder (ADHD) is a common behavioral syndrome that begins in childhood and affects 3.4% of children worldwide. Due to its etiological complexity, there are no consistent biomarkers for ADHD, however the high heritability presented by the disorder indicates a genetic...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery Vol. 228; p. 107714
Main Authors: Carvalho, Gleyson Francisco da Silva, Costa, Thais Virginia Moura Machado, Nascimento, Amom Mendes, Wolff, Beatriz Martins, Damasceno, Julian Gabriel, Vieira, Lucas Liro, Almeida, Vanessa Tavares, Oliveira, Yanca Gasparini de, Mello, Claudia Berlim de, Muszkat, Mauro, Kulikowski, Leslie Domenici
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-05-2023
Elsevier Limited
Subjects:
ADHD
Age
Aging
Attention Deficit Disorder with Hyperactivity - genetics
Attention Deficit Disorder with Hyperactivity - metabolism
Attention deficit hyperactivity disorder
Biomarkers
Biomarkers - metabolism
Bisulfite
Blood
Cancer
Child
Children
DNA methylation
DNA Methylation - genetics
DNAmAge
Energy metabolism
Epi-signature
Epigenesis, Genetic
Epigenetic
Epigenetics
Etiology
Gene expression
Genes
Genetic testing
Heritability
Humans
Hyperactivity
Kruskal-Wallis test
Mental disorders
Metabolism
Methylation
Nervous system
Neurology
Ontology
Oxidative metabolism
Oxidative stress
ADHD
DNAmAge
Epigenetic
Methylation
Epi-signature
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Summary:Attention Deficit/Hyperactivity Disorder (ADHD) is a common behavioral syndrome that begins in childhood and affects 3.4% of children worldwide. Due to its etiological complexity, there are no consistent biomarkers for ADHD, however the high heritability presented by the disorder indicates a genetic/epigenetic influence. The main epigenetic mechanism is DNA methylation, a process with an important role in gene expression and in many psychiatric disorders. Thus, our study sought to identify epi-signatures biomarkers in 29 children clinically diagnosed with ADHD. After DNA extraction and bisulfite conversion, we performed methylation array experiment for differential methylation, ontological and biological age analysis. The biological response in ADHD patients was not sufficient to determine a conclusive epi-signature in our study. However, our results highlighted the interaction of energy metabolism and oxidative stress pathways in ADHD patients detected by differential methylation patterns. Furthermore, we were able to identify a marginal association between the DNAmAge and ADHD. Our study present new methylation biomarkers findings associated with energy metabolism and oxidative stress pathways, in addition to DNAmAge in ADHD patients. However, we propose that further multiethnic studies, with larger cohorts and including maternal conditions, are necessary to demonstrate a definitive association between ADHD and these methylation biomarkers. •There is still no conclusive episignature for ADHD.•Oxidative stress and energy metabolism play a crucial role in the pathophysiology of ADHD.•Biological methylation age (DNAmAge) acceleration has a marginal association with clinical status of ADHD.
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ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2023.107714