Search Results - "Damaj, M Imad"

Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse by Toma, Wisam, Kyte, S. Lauren, Bagdas, Deniz, Alkhlaif, Yasmin, Alsharari, Shakir D., Lichtman, Aron H., Chen, Zhi-Jian, Del Fabbro, Egidio, Bigbee, John W., Gewirtz, David A., Damaj, M. Imad

“…Paclitaxel, one of the most commonly used cancer chemotherapeutic drugs, effectively extends the progression-free survival of breast, lung, and ovarian cancer…”
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Voluntary nicotine consumption and reward in a subset of diversity outbred founder strains by Rahman, Yumna, Buzzi, Belle, Rogers, Walker, Miles, Michael F, Damaj, M Imad

“…Background: Nicotine is largely responsible for the initiation and maintenance of tobacco dependence and contributes to a global health problem. Aims: This…”
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Role of neuronal nicotinic acetylcholine receptors in cannabinoid dependence by Buzzi, Belle, Koseli, Eda, Moncayo, Lauren, Shoaib, Mohammed, Damaj, M Imad

“…Cannabis is among the most widely consumed psychoactive drugs around the world and cannabis use disorder (CUD) has no current approved pharmacological…”
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Identification and targeting of a unique NaV1.7 domain driving chronic pain by Gomez, Kimberly, Stratton, Harrison J, Duran, Paz, Loya, Santiago, Tang, Cheng, Calderon-Rivera, Aida, François-Moutal, Liberty, Khanna, May, Madura, Cynthia L, Luo, Shizhen, McKiver, Bryan, Choi, Edward, Ran, Dongzhi, Boinon, Lisa, Perez-Miller, Samantha, Damaj, M Imad, Moutal, Aubin, Khanna, Rajesh

“…Small molecules directly targeting the voltage-gated sodium channel (VGSC) NaV1.7 have not been clinically successful. We reported that preventing the addition…”
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Short-chain fatty acid, butyrate prevents morphine-and paclitaxel-induced nociceptive hypersensitivity by Jessup, Dawn, Woods, Kareem, Thakker, Sach, Damaj, M. Imad, Akbarali, Hamid I.

“…Nociceptive hypersensitivity is a significant side effect with the chronic administration of opioids as well as chemotherapeutics. Both opioid-induced…”
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The α9α10 nicotinic acetylcholine receptors antagonist α-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model by AlSharari, Shakir D., Toma, Wisam, Mahmood, Hafiz M., Michael McIntosh, J., Imad Damaj, M.

“…Nicotinic acetylcholine receptors can regulate inflammation primarily through the vagus nerve via the cholinergic anti-inflammatory pathway. α9α10 nicotinic…”
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Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs) by Qian, Jie, Mummalaneni, Shobha, Grider, John R, Damaj, M Imad, Lyall, Vijay

“…Nicotine evokes chorda tympani (CT) taste nerve responses and an aversive behavior in Trpm5 knockout (KO) mice. The agonists and antagonists of nicotinic…”
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The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain by Bagdas, Deniz, Wilkerson, Jenny L, Kulkarni, Abhijit, Toma, Wisam, AlSharari, Shakir, Gul, Zulfiye, Lichtman, Aron H, Papke, Roger L, Thakur, Ganesh A, Damaj, M Imad

“…Background and Purpose Orthosteric agonists and positive allosteric modulators (PAMs) of the α7 nicotinic ACh receptor (nAChR) represent novel therapeutic…”
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The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models by Freitas, Kelen, Carroll, F Ivy, Damaj, M Imad

“…The α7 nicotinic acetylcholine receptor (nAChR) subtype is abundantly expressed in the central nervous system and in the periphery. Recent evidence suggests…”
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A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE by Godin, Jean-Rémi, Roy, Patrick, Quadri, Marta, Bagdas, Deniz, Toma, Wisam, Narendrula-Kotha, Ramya, Kishta, Osama A., Damaj, M. Imad, Horenstein, Nicole A., Papke, Roger L., Simard, Alain R.

“…•Mecamylamine and m-bromo PEP exert anti-inflammatory effects.•Mecamylamine and m-bromo PEP reduce EAE disease severity.•m-bromo PEP reduces CFA-induced…”
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Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy by Curry, Zachary A, Wilkerson, Jenny L, Bagdas, Deniz, Kyte, S Lauren, Patel, Nipa, Donvito, Giulia, Mustafa, Mohammed A, Poklis, Justin L, Niphakis, Micah J, Hsu, Ku-Lung, Cravatt, Benjamin F, Gewirtz, David A, Damaj, M Imad, Lichtman, Aron H

“…Although paclitaxel effectively treats various cancers, its debilitating peripheral neuropathic pain side effects often persist long after treatment has ended…”
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Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: Studies in transgenic mice by AlSharari, Shakir D., Freitas, Kelen, Damaj, M. Imad

“…A growing body of evidence indicates that α7 nicotinic receptor subtypes play an important role in chronic inflammatory and neuropathic pain signaling. In the…”
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New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs by Bagdas, Deniz, Gurun, Mine S, Flood, Pamela, Papke, Roger L, Damaj, M Imad

“…Background: Nicotine and nicotinic acetylcholine receptors (nAChRs) have been explored for the past three decades as targets for pain control. The aim of this…”
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C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception by Bryant, Camron D, Bagdas, Deniz, Goldberg, Lisa R, Khalefa, Tala, Reed, Eric R, Kirkpatrick, Stacey L, Kelliher, Julia C, Chen, Melanie M, Johnson, William E, Mulligan, Megan K, Imad Damaj, M

“…Sensitivity to different pain modalities has a genetic basis that remains largely unknown. Employing closely related inbred mouse substrains can facilitate…”
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Differential roles of α6β2 and α4β2 neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice by Sanjakdar, Sarah S, Maldoon, Pretal P, Marks, Michael J, Brunzell, Darlene H, Maskos, Uwe, McIntosh, J Michael, Bowers, M Scott, Damaj, M Imad

“…Mesolimbic α6* nicotinic acetylcholine receptors (nAChRs) are thought to have an important role in nicotine behavioral effects. However, little is known about…”
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N‐acylethanolamine‐hydrolysing acid amidase: A new potential target to treat paclitaxel‐induced neuropathy by Toma, Wisam, Caillaud, Martial, Patel, Nipa H., Tran, Tammy H., Donvito, Giulia, Roberts, Jane, Bagdas, Deniz, Jackson, Asti, Lichtman, Aron, Gewirtz, David A., Makriyannis, Alexandros, Malamas, Michael S., Imad Damaj, M.

“…Background Although paclitaxel is an effective chemotherapeutic agent used to treat multiple types of cancer (e.g. breast, ovarian, neck and lung), it also…”
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Conditional expression of HIV‐1 tat in the mouse alters the onset and progression of tonic, inflammatory and neuropathic hypersensitivity in a sex‐dependent manner by Bagdas, Deniz, Paris, Jason J., Carper, Moriah, Wodarski, Rachel, Rice, Andrew S. C., Knapp, Pamela E., Hauser, Kurt F., Damaj, M. Imad

“…Background At least one‐third of HIV‐1‐afflicted individuals experience peripheral neuropathy. Although the underlying mechanisms are not known, they may…”
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Effects of alpha 7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models by Freitas, Kelen, Ghosh, Sudeshna, Ivy Carroll, F., Lichtman, Aron H., Imad Damaj, M.

“…Agonists and positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) are currently being considered as novel therapeutic…”
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C57BL/6 substrain differences in formalin-induced pain-like behavioral responses by Ulker, Esad, Caillaud, Martial, Patel, Trusha, White, Alyssa, Rashid, Danyal, Alqasem, Mashael, Lichtman, Aron H., Bryant, Camron D., Damaj, M. Imad

“…Substantial evidence from preclinical models of pain suggests that basal and noxious nociceptive sensitivity, as well as antinociceptive responses to drugs,…”
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Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice by Alsharari, Shakir D, King, Justin R, Nordman, Jacob C, Muldoon, Pretal P, Jackson, Asti, Zhu, Andy Z X, Tyndale, Rachel F, Kabbani, Nadine, Damaj, M Imad

“…Although menthol, a common flavoring additive to cigarettes, has been found to impact the addictive properties of nicotine cigarettes in smokers little is…”
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