Search Results - "Dam, Tarun K"

Effects of Clustered Epitopes in Multivalent Ligand−Receptor Interactions by Dam, Tarun K, Brewer, C. Fred

“…Many biological ligands are composed of clustered binding epitopes. However, the effects of clustered epitopes on the affinity of ligand−receptor interactions…”
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Selectively Modified Lactose and N -Acetyllactosamine Analogs at Three Key Positions to Afford Effective Galectin-3 Ligands by Abdullayev, Shuay, Kadav, Priyanka, Bandyopadhyay, Purnima, Medrano, Francisco Javier, Rabinovich, Gabriel A, Dam, Tarun K, Romero, Antonio, Roy, René

“…Galectins constitute a family of galactose-binding lectins overly expressed in the tumor microenvironment as well as in innate and adaptive immune cells, in…”
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Thermodynamics of Multivalent Carbohydrate−Lectin Cross-Linking Interactions: Importance of Entropy in the Bind and Jump Mechanism by Dam, Tarun K, Gerken, Thomas A, Brewer, C. Fred

“…The high affinity (K d = 0.2 nM) of the soybean agglutinin (SBA), a tetrameric GalNAc specific lectin, for a modified form of porcine submaxillary mucin, a…”
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Thermodynamic Studies of Lectin−Carbohydrate Interactions by Isothermal Titration Calorimetry by Dam, Tarun K, Brewer, C. Fred

“…Dam and Brewer present a comprehensive review of thermodynamic data in the literature for lectin-carbohydrate interactions over the past decade. ITC-derived…”
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Isothermal Titration Calorimetry Reveals Differential Binding Thermodynamics of Variable Region-identical Antibodies Differing in Constant Region for a Univalent Ligand by Dam, Tarun K., Torres, Marcela, Brewer, C. Fred, Casadevall, Arturo

“…The classical view of immunoglobulin molecules posits two functional domains defined by the variable (V) and constant (C) regions, which are responsible for…”
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Lectins as pattern recognition molecules: The effects of epitope density in innate immunity by Dam, Tarun K, Brewer, C. Fred

“…The innate immune response of multicellular organisms is initiated by the binding of soluble and membrane-bound host molecules including lectins to the surface…”
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Thermodynamic, Kinetic, and Electron Microscopy Studies of Concanavalin A and Dioclea grandiflora Lectin Cross-linked with Synthetic Divalent Carbohydrates by Dam, Tarun K., Oscarson, Stefan, Roy, René, Das, Sanjoy K., Pagé, Daniel, Macaluso, Frank, Brewer, C. Fred

“…The jack bean lectin concanavalin A (ConA) and the Dioclea grandiflora lectin (DGL) are highly homologous Man/Glc-specific members of the Diocleinae subtribe…”
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Revealing the Identity of Human Galectin-3 as a Glycosaminoglycan-Binding Protein by Edwards, Jared L, Kadav, Priyanka D, Bandyopadhyay, Purnima, Dam, Tarun K

“…Human galectin-3 (Gal-3) is a β-galactoside-binding lectin. This multitasking protein preferentially interacts with N-acetyllactosamine moieties on…”
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LMNglyPred: prediction of human N-linked glycosylation sites using embeddings from a pre-trained protein language model by Pakhrin, Subash C, Pokharel, Suresh, Aoki-Kinoshita, Kiyoko F, Beck, Moriah R, Dam, Tarun K, Caragea, Doina, KC, Dukka B

“…Abstract Protein N-linked glycosylation is an important post-translational mechanism in Homo sapiens, playing essential roles in many vital biological…”
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Thermodynamic Binding Parameters of Individual Epitopes of Multivalent Carbohydrates to Concanavalin A As Determined by “Reverse” Isothermal Titration Microcalorimetry by Dam, Tarun K, Roy, René, Pagé, Daniel, Brewer, C. Fred

“…The preceding paper [Dam, T. K., Roy, R., Pagé, D., and Brewer, C. F. (2002) Biochemistry 41, 1351−1358] demonstrated that Hill plots of isothermal titration…”
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Multitasking Human Lectin Galectin‑3 Interacts with Sulfated Glycosaminoglycans and Chondroitin Sulfate Proteoglycans by Talaga, Melanie L, Fan, Ni, Fueri, Ashli L, Brown, Robert K, Bandyopadhyay, Purnima, Dam, Tarun K

“…Glycosaminoglycan (GAG) binding proteins (GAGBPs), including growth factors, cytokines, morphogens, and extracellular matrix proteins, interact with both free…”
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Rapid Detection and Purification of Galectin-3 by the Capture and Release (CaRe) Method by Kadav, Priyanka D, Edwards, Jared L, Krycia, Jessica, Bandyopadhyay, Purnima, Dam, Tarun K

“…Specific interactions between lectins and glycoproteins determine the outcomes of numerous biological processes. To elucidate the roles of lectins and…”
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Multivalent protein-carbohydrate interactions: isothermal titration microcalorimetry studies by Dam, Tarun K, Brewer, C Fred

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Mechanism of Mucin Recognition by Lectins: A Thermodynamic Study by Dam, Tarun K, Edwards, Jared L, Kadav, Priyanka D, Brewer, C Fred

“…Isothermal titration microcalorimetry (ITC) can directly determine the thermodynamic binding parameters of biological molecules including affinity constant,…”
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A capture and release method based on noncovalent ligand cross-linking and facile filtration for purification of lectins and glycoproteins by Welch, Christina J., Talaga, Melanie L., Kadav, Priyanka D., Edwards, Jared L., Bandyopadhyay, Purnima, Dam, Tarun K.

“…Glycan-binding proteins such as lectins are ubiquitous proteins that mediate many biological functions. To study their various biological activities and…”
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Measuring Multivalent Binding Interactions by Isothermal Titration Calorimetry by Dam, Tarun K, Talaga, Melanie L, Fan, Ni, Brewer, Curtis F

“…Multivalent glycoconjugate-protein interactions are central to many important biological processes. Isothermal titration calorimetry (ITC) can potentially…”
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Multivalent Lectin-Carbohydrate Interactions: Energetics and Mechanisms of Binding by Dam, Tarun K, Brewer, C Fred

“…The biological signaling properties of lectins, which are carbohydrate-binding proteins, are due to their ability to bind and cross-link multivalent…”
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Probing lectin-mucin interactions by isothermal titration microcalorimetry by Dam, Tarun K, Brewer, C Fred

“…Isothermal titration microcalorimetry (ITC) can directly determine the thermodynamic binding parameters of biological molecules including affinity constant,…”
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Galectins Bind to the Multivalent Glycoprotein Asialofetuin with Enhanced Affinities and a Gradient of Decreasing Binding Constants by Dam, Tarun K, Gabius, Hans-J, André, Sabine, Kaltner, Herbert, Lensch, Martin, Brewer, C. Fred

“…Our previous isothermal titration microcalorimetry (ITC) studies of the binding of synthetic multivalent carbohydrates to the Man/Glc-specific lectins…”
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Maintenance of cell surface glycan density by lectin-glycan interactions: A homeostatic and innate immune regulatory mechanism by Dam, Tarun K, Brewer, Fred C

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