Search Results - "Dam, JP"

Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: a randomised open-label trial, the 2NN Study by van Leth, F, Phanuphak, P, Ruxrungtham, K, Baraldi, E, Miller, S, Gazzard, B, Cahn, P, Lalloo, UG, van der Westhuizen, IP, Malan, DR, Johnson, MA, Santos, BR, Mulcahy, F, Wood, R, Levi, GC, Reboredo, G, Squires, K, Cassetti, I, Petit, D, Raffi, F, Katlama, C, Murphy, RL, Horban, A, Dam, JP, Hassink, E, van Leeuwen, R, Robinson, P, Wit, FW, Lange, JMA

“…The 2NN Study was a randomised comparison of the non-nucleoside reverse-transcriptase inhibitors (NNRTI) nevirapine and efavirenz. In this multicentre,…”
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Evolution of modular intraflagellar transport from a coatomer-like progenitor by van Dam, Teunis J. P., Townsend, Matthew J., Turk, Martin, Schlessinger, Avner, Sali, Andrej, Field, Mark C., Huynen, Martijn A.

“…The intraflagellar transport (IFT) complex is an integral component of the cilium, a quintessential organelle of the eukaryotic cell. The IFT system consists…”
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TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome by Lambacher, Nils J., Bruel, Ange-Line, van Dam, Teunis J. P., Szymańska, Katarzyna, Slaats, Gisela G., Kuhns, Stefanie, McManus, Gavin J., Kennedy, Julie E., Gaff, Karl, Wu, Ka Man, van der Lee, Robin, Burglen, Lydie, Doummar, Diane, Rivière, Jean-Baptiste, Faivre, Laurence, Attié-Bitach, Tania, Saunier, Sophie, Curd, Alistair, Peckham, Michelle, Giles, Rachel H., Johnson, Colin A., Huynen, Martijn A., Thauvin-Robinet, Christel, Blacque, Oliver E.

“…The ciliary transition zone (TZ) at the base of cilia is thought to gate entry of proteins into the cilium. The authors characterize a role for TMEM107, a…”
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Evolution of the TOR Pathway by van Dam, Teunis J. P., Zwartkruis, Fried J. T., Bos, Johannes L., Snel, Berend

“…The TOR kinase is a major regulator of growth in eukaryotes. Many components of the TOR pathway are implicated in cancer and metabolic diseases in humans…”
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Ciliary force-responsive striated fibers promote basal body connections and cortical interactions by Soh, Adam W J, van Dam, Teunis J P, Stemm-Wolf, Alexander J, Pham, Andrew T, Morgan, Garry P, O'Toole, Eileen T, Pearson, Chad G

“…Multi-ciliary arrays promote fluid flow and cellular motility using the polarized and coordinated beating of hundreds of motile cilia. Tetrahymena basal bodies…”
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The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium by van Dam, Teunis Jp, Wheway, Gabrielle, Slaats, Gisela G, Huynen, Martijn A, Giles, Rachel H

“…The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to…”
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Protein complex evolution does not involve extensive network rewiring by van Dam, Teunis J P, Snel, Berend

“…The formation of proteins into stable protein complexes plays a fundamental role in the operation of the cell. The study of the degree of evolutionary…”
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Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi by van Dam, Teunis J.P., Rehmann, Holger, Bos, Johannes L., Snel, Berend

“…The members of the Ras-like superfamily of small GTP-binding proteins are molecular switches that are in general regulated in time and space by guanine…”
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Inferring the Evolutionary History of Your Favorite Protein: A Guide for Molecular Biologists by Hooff, Jolien J.E., Tromer, Eelco, Dam, Teunis J.P., Kops, Geert J.P.L., Snel, Berend

“…Comparative genomics has proven a fruitful approach to acquire many functional and evolutionary insights into core cellular processes. Here it is argued that…”
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