Search Results - "Daly, Norelle L"

Revisiting Inflammatory Bowel Disease: Pathology, Treatments, Challenges and Emerging Therapeutics Including Drug Leads from Natural Products by Yeshi, Karma, Ruscher, Roland, Hunter, Luke, Daly, Norelle L, Loukas, Alex, Wangchuk, Phurpa

“…Inflammatory bowel disease (IBD) is a chronic and life-long disease characterized by gastrointestinal tract inflammation. It is caused by the interplay of the…”
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Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase by Harris, Karen S., Durek, Thomas, Kaas, Quentin, Poth, Aaron G., Gilding, Edward K., Conlan, Brendon F., Saska, Ivana, Daly, Norelle L., van der Weerden, Nicole L., Craik, David J., Anderson, Marilyn A.

“…Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as pharmaceutical scaffolds, but fundamentals of their biosynthetic origin…”
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Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy by Chan, Lai Yue, Craik, David J., Daly, Norelle L.

“…Peptide analogues derived from bioactive hormones such as somatostatin or certain growth factors have great potential as angiogenesis inhibitors for cancer…”
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ApInAPDB: a database of apoptosis-inducing anticancer peptides by Faraji, Naser, Arab, Seyed Shahriar, Doustmohammadi, Alireza, Daly, Norelle L., Khosroushahi, Ahmad Yari

“…ApInAPDB (Apoptosis-Inducing Anticancer Peptides Database) consists of 818 apoptosis-inducing anticancer peptides which are manually collected from research…”
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Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia by Hu, Mingjing, Eviston, David, Hsu, Peter, Mariño, Eliana, Chidgey, Ann, Santner-Nanan, Brigitte, Wong, Kahlia, Richards, James L., Yap, Yu Anne, Collier, Fiona, Quinton, Ann, Joung, Steven, Peek, Michael, Benzie, Ron, Macia, Laurence, Wilson, David, Ponsonby, Ann-Louise, Tang, Mimi L. K., O’Hely, Martin, Daly, Norelle L., Mackay, Charles R., Dahlstrom, Jane E., Vuillermin, Peter, Nanan, Ralph

“…Maternal immune dysregulation seems to affect fetal or postnatal immune development. Preeclampsia is a pregnancy-associated disorder with an immune basis and…”
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Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design by Koehbach, Johannes, O'Brien, Margaret, Muttenthaler, Markus, Miazzo, Marion, Akcan, Muharrem, Elliott, Alysha G., Daly, Norelle L., Harvey, Peta J., Arrowsmith, Sarah, Gunasekera, Sunithi, Smith, Terry J., Wray, Susan, Göransson, Ulf, Dawson, Philip E., Crai, David J., Freissmutha, Michael, Grubera, Christian W.

“…Cyclotides are plant peptides comprising a circular backbone and three conserved disulfide bonds that confer them with exceptional stability. They were…”
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High-affinity Cyclic Peptide Matriptase Inhibitors by Quimbar, Pedro, Malik, Uru, Sommerhoff, Christian P., Kaas, Quentin, Chan, Lai Y., Huang, Yen-Hua, Grundhuber, Maresa, Dunse, Kerry, Craik, David J., Anderson, Marilyn A., Daly, Norelle L.

“…The type II transmembrane serine protease matriptase is a key activator of multiple signaling pathways associated with cell proliferation and modification of…”
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Discovery, structure and biological activities of cyclotides by Daly, Norelle L., Rosengren, K. Johan, Craik, David J.

“…Cyclotides are small disulfide-rich peptides that are characterized by a head-to-tail cyclized peptide backbone and a knotted arrangement of three conserved…”
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Disulfide Bridges: Bringing Together Frustrated Structure in a Bioactive Peptide by Zhang, Yi, Schulten, Klaus, Gruebele, Martin, Bansal, Paramjit S., Wilson, David, Daly, Norelle L.

“…Disulfide bridges are commonly found covalent bonds that are usually believed to maintain structural stability of proteins. Here, we investigate the influence…”
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Discovery of an unusual biosynthetic origin for circular proteins in legumes by Poth, Aaron G, Colgrave, Michelle L, Lyons, Russell E, Daly, Norelle L, Craik, David J

“…Cyclotides are plant-derived proteins that have a unique cyclic cystine knot topology and are remarkably stable. Their natural function is host defense, but…”
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Nuclear Magnetic Resonance seq (NMRseq): A New Approach to Peptide Sequence Tags by Wilson, David, Daly, Norelle L

“…Structural analysis of peptides with nuclear magnetic resonance (NMR) spectroscopy generally relies on knowledge of the primary sequence to enable assignment…”
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Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes by Dongol, Yashad, Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C., Lewis, Richard J.

“…The structure-function and optimization studies of Na V -inhibiting spider toxins have focused on developing selective inhibitors for peripheral pain-sensing…”
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Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold by Huang, Yen-Hua, Henriques, Sónia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin, Craik, David J.

“…The constitutively active tyrosine kinase BCR-ABL is the underlying cause of chronic myeloid leukemia (CML). Current CML treatments rely on the long-term use…”
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Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration by Chan, Lai Yue, Craik, David J, Daly, Norelle L

“…Tumour formation is dependent on nutrient and oxygen supply from adjacent blood vessels. Angiogenesis inhibitors can play a vital role in controlling blood…”
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Gastrointestinal Helminth Infection Improves Insulin Sensitivity, Decreases Systemic Inflammation, and Alters the Composition of Gut Microbiota in Distinct Mouse Models of Type 2 Diabetes by Khudhair, Zainab, Alhallaf, Rafid, Eichenberger, Ramon M, Whan, Jen, Kupz, Andreas, Field, Matt, Krause, Lutz, Wilson, David T, Daly, Norelle L, Giacomin, Paul, Sotillo, Javier, Loukas, Alex

“…Type 2 diabetes (T2D) is a major health problem and is considered one of the top 10 diseases leading to death globally. T2D has been widely associated with…”
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The Biological Activity of the Prototypic Cyclotide Kalata B1 Is Modulated by the Formation of Multimeric Pores by Huang, Yen-Hua, Colgrave, Michelle L., Daly, Norelle L., Keleshian, Asbed, Martinac, Boris, Craik, David J.

“…The cyclotides are a large family of circular mini-proteins containing a cystine knot motif. They are expressed in plants as defense-related proteins, with…”
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A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain by Gui, Junhong, Liu, Boyi, Cao, Guan, Lipchik, Andrew M., Perez, Minervo, Dekan, Zoltan, Mobli, Mehdi, Daly, Norelle L., Alewood, Paul F., Parker, Laurie L., King, Glenn F., Zhou, Yufeng, Jordt, Sven-Eric, Nitabach, Michael N.

“…The venoms of predators have been an excellent source of diverse highly specific peptides targeting ion channels. Here we describe the first known peptide…”
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Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359 by Zhang, Hang, Nielsen, Alexander L., Boesgaard, Michael W., Harpsøe, Kasper, Daly, Norelle L., Xiong, Xiao-Feng, Underwood, Christina R., Haugaard-Kedström, Linda M., Bräuner-Osborne, Hans, Gloriam, David E., Strømgaard, Kristian

“…G proteins are key mediators in the signaling of G protein-coupled receptors and involved in a plethora of important physiological processes. The natural…”
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Alanine Scanning Mutagenesis of the Prototypic Cyclotide Reveals a Cluster of Residues Essential for Bioactivity by Simonsen, Shane M., Sando, Lillian, Rosengren, K. Johan, Wang, Conan K., Colgrave, Michelle L., Daly, Norelle L., Craik, David J.

“…The cyclotides are stable plant-derived mini-proteins with a topologically circular peptide backbone and a knotted arrangement of three disulfide bonds that…”
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Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula by Hardy, Margaret C, Daly, Norelle L, Mobli, Mehdi, Morales, Rodrigo A V, King, Glenn F

“…Many insect pests have developed resistance to existing chemical insecticides and consequently there is much interest in the development of new insecticidal…”
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