Search Results - "Daly, Carole"
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Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
Published in Cell reports (Cambridge) (23-03-2021)“…The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of…”
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Journal Article -
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β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
Published in eLife (19-10-2023)“…The vasopressin type 2 receptor (V R) is an essential G protein-coupled receptor (GPCR) in renal regulation of water homeostasis. Upon stimulation, the V R…”
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Journal Article -
3
Structural Elements Directing G Proteins and β‑Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants
Published in ACS pharmacology & translational science (11-02-2022)“…G protein-coupled receptors (GPCRs) can engage distinct subsets of signaling pathways, but the structural determinants of this functional selectivity remain…”
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Journal Article -
4
Gα q signalling from endosomes: A new conundrum
Published in British journal of pharmacology (16-10-2023)“…Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of…”
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Journal Article -
5
β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
Published in eLife (19-10-2023)“…The vasopressin type 2 receptor (V 2 R) is an essential G protein-coupled receptor (GPCR) in renal regulation of water homeostasis. Upon stimulation, the V 2 R…”
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Journal Article -
6
Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor
Published in Cell (22-08-2024)“…The Duffy antigen receptor is a seven-transmembrane (7TM) protein expressed primarily at the surface of red blood cells and displays strikingly promiscuous…”
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Journal Article -
7
Alkaline phosphatase activity in United Kingdom cheeses made from bovine pasteurised milk
Published in International journal of dairy technology (01-05-2014)“…The aim of this study was to assess the alkaline phosphatase activity of representative cheeses made from pasteurised milk in the United Kingdom. The results…”
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Journal Article -
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Perceptions among nurses and physicians regarding enablers and barriers to effectiveness in the retention of cardiac life support skills
Published 01-01-2001“…Patients in acute care settings fully expect that they will be resuscitated if they have a cardiac arrest. It is therefore necessary for nurses and physicians…”
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Dissertation