Search Results - "Dalton, Derek M."

Ligand design for Rh( iii )-catalyzed C–H activation: an unsymmetrical cyclopentadienyl group enables a regioselective synthesis of dihydroisoquinolones by Hyster, Todd K., Dalton, Derek M., Rovis, Tomislav

“…We report the regioselective synthesis of dihydroisoquinolones from aliphatic alkenes and O -pivaloyl benzhydroxamic acids mediated by a Rh( iii ) precatalyst…”
Get full text

N1-Selective Methylation of Pyrazoles via α‑Halomethylsilanes as Masked Methylating Reagents by Yang, Emma, Dalton, Derek M.

“…The development of a highly selective N-methylation of pyrazole heterocycles using commercially available, bench-stable α-halomethylsilanes as masked…”
Get full text

Phosphoramidite-rhodium complexes as catalysts for the asymmetric [2 + 2 + 2] cycloaddition of alkenyl isocyanates and alkynes by Friedman, Rebecca Keller, Oberg, Kevin M., Dalton, Derek M., Rovis, Tomislav

“…The discovery and development of the asymmetric rhodium-catalyzed [2 + 2 + 2] cycloaddition of alkenyl isocyanates and exogenous alkynes to form indolizinone…”
Get full text

Catalytic Asymmetric Intermolecular Stetter Reaction of Heterocyclic Aldehydes with Nitroalkenes: Backbone Fluorination Improves Selectivity by DiRocco, Daniel A, Oberg, Kevin M, Dalton, Derek M, Rovis, Tomislav

“…The catalytic asymmetric intermolecular Stetter reaction of heterocyclic aldehydes and nitroalkenes has been developed. We have identified a strong…”
Get full text

Utopia Point Bayesian Optimization Finds Condition-Dependent Selectivity for N‑Methyl Pyrazole Condensation by Dalton, Derek M., Walroth, Richard C., Rouget-Virbel, Caroline, Mack, Kyle A., Toste, F. Dean

“…Utopia Point Bayesian Optimization (UPBO) was used to identify reaction conditions that are highly selective for the formation of N1 and N2-methyl-3-aryl…”
Get full text

Catalytic, Asymmetric Indolizidinone Aza-Quaternary Stereocenter Synthesis: Expedient Synthesis of the Cylindricine Alkaloid Core by Dalton, Derek M, Rovis, Tomislav

“…The Rh(I)•CKphos catalyzed [2 + 2 + 2] cycloaddition of 1,1-disubstituted alkenyl isocyanates and alkyl alkynes selectively forms previously inaccessible…”
Get full text

Organometallic chemistry: C-H carboxylation takes gold by Dalton, Derek M, Rovis, Tomislav

Get full text

Umpolung Flow Chemistry for the Synthesis of a 3-Oxo-3 H -spiro[benzofuran-2,4'-piperidine] Building Block by Pompeo, Matthew M, Kelly, Sean M, St-Jean, Frédéric, Bass, Thomas M, Dalton, Derek M, Zell, Daniel, Han, Chong, Sirois, Lauren E, Gosselin, Francis

“…An efficient and scalable route to -butyl 3-oxo-3 -spiro[benzofuran-2,4'-piperidine]-1'-carboxylate, a central prochiral intermediate in the synthesis of SHP2…”
Get full text

Supramolecular Ga4L6(12-) Cage Photosensitizes 1,3-Rearrangement of Encapsulated Guest via Photoinduced Electron Transfer by Dalton, Derek M, Ellis, Scott R, Nichols, Eva M, Mathies, Richard A, Toste, F Dean, Bergman, Robert G, Raymond, Kenneth N

“…The K12Ga4L6 supramolecular cage is photoactive and enables an unprecedented photoreaction not observed in bulk solution. Ga4L6(12-) cages photosensitize the…”
Get full text

Umpolung Flow Chemistry for the Synthesis of a 3‑Oxo‑3H‑spiro[benzofuran-2,4′-piperidine] Building Block by Pompeo, Matthew M., Kelly, Sean M., St-Jean, Frédéric, Bass, Thomas M., Dalton, Derek M., Zell, Daniel, Han, Chong, Sirois, Lauren E., Gosselin, Francis

“…An efficient and scalable route to tert-butyl 3-oxo-3H-spiro­[benzofuran-2,4′-piperidine]-1′-carboxylate, a central prochiral intermediate in the synthesis of…”
Get full text

Zn-Catalyzed Enantio- and Diastereoselective Formal [4 + 2] Cycloaddition Involving Two Electron-Deficient Partners: Asymmetric Synthesis of Piperidines from 1‑Azadienes and Nitro-Alkenes by Chu, John C. K, Dalton, Derek M, Rovis, Tomislav

“…We report a catalytic asymmetric synthesis of piperidines through [4 + 2] cycloaddition of 1-azadienes and nitro-alkenes. The reaction uses earth abundant Zn…”
Get full text

Correction: Ligand design for Rh(iii)-catalyzed C-H activation: an unsymmetrical cyclopentadienyl group enables a regioselective synthesis of dihydroisoquinolones by Hyster, Todd K, Dalton, Derek M, Rovis, Tomislav

“…Correction for 'Ligand design for Rh( iii )-catalyzed C-H activation: an unsymmetrical cyclopentadienyl group enables a regioselective synthesis of…”
Get full text

Catalytic, Asymmetric Indolizidinone Aza-Quaternary Stereocenter Synthesis: Expedient Synthesis of the Cylindricine Alkaloids Core by Dalton, Derek M, Rovis, Tomislav

Get full text

Correction: Ligand design for Rh(iii)-catalyzed C-H activation: an unsymmetrical cyclopentadienyl group enables a regioselective synthesis of dihydroisoquinolones by Hyster, Todd K, Dalton, Derek M, Rovis, Tomislav

“…Correction for 'Ligand design for Rh( iii )-catalyzed C-H activation: an unsymmetrical cyclopentadienyl group enables a regioselective synthesis of…”
Get full text

Enantioselective Rhodium-Catalyzed [2 + 2 + 2] Cycloadditions of Terminal Alkynes and Alkenyl Isocyanates: Mechanistic Insights Lead to a Unified Model that Rationalizes Product Selectivity by Dalton, Derek M, Oberg, Kevin M, Yu, Robert T, Lee, Ernest E, Perreault, Stéphane, Oinen, Mark Emil, Pease, Melissa L, Malik, Guillaume, Rovis, Tomislav

“…This manuscript describes the development and scope of the asymmetric rhodium-catalyzed [2 + 2 + 2] cycloaddition of terminal alkynes and alkenyl isocyanates…”
Get full text

Development of a Robust Pd-Catalyzed C–S Coupling for the Synthesis of Janus Kinase Inhibitor GDC-9918 by Dalton, Derek M., Siu, Juno Castillo, Varona-Ortiz, Marcelino, Sowell, C. Gregory, Gosselin, Francis

“…The development of an in situ formed (Xantphos)Pd oxidative addition complex made possible a robust, scalable C–S coupling of a functionalized aryl bromide…”
Get full text

Streamlined Synthesis of SHP2 Inhibitor GDC-1971 Enhanced by a Telescoped Schotten-Baumann S N Ar and Reactive Crystallization Cascade by Sirois, Lauren E., White, Nicholas A., Shen, Jeff, Dalton, Derek M., Zell, Daniel, St-Jean, Frédéric, Gosselin, Francis

“…An improved synthetic process for SHP2 inhibitor GDC-1971 (migoprotafib) was developed to address challenges associated with the scalability and robustness of…”
Get full text

Catalytic, Asymmetric Indolizidinone Aza-Quaternary Stereocenter Synthesis: Expedient Synthesis of the Cylindricine Alkaloids Core by Dalton, Derek M., Rovis, Tomislav

“…The Rh(I)•CKphos catalyzed [2+2+2] cycloaddition of 1,1-disubstituted alkenyl isocyanates and alkyl alkynes selectively forms previously inaccessible…”
Get full text

Zn-catalyzed Enantio- and Diastereoselective Formal [4+2] Cycloaddition Involving Two Electron-Deficient Partners: Asymmetric Synthesis of Piperidines from 1-Azadienes and Nitroalkenes by Chu, John C. K., Dalton, Derek M., Rovis, Tomislav

“…We report a catalytic asymmetric synthesis of piperidines through [4+2] cycloaddition of 1-azadienes and nitroalkenes. The reaction uses earth abundant Zn as…”
Get full text

Ligand Design for Rh(III)-Catalyzed C-H Activation: An Unsymmetrical Cyclopentadienyl Enables a Regioselective Synthesis of Dihydroisoquinolones by Hyster, Todd K, Dalton, Derek M, Rovis, Tomislav

“…We report the regioselective synthesis of dihydroisoquinolones from aliphatic alkenes and -pivaloyl benzhydroxamic acids mediated by a Rh(III) precatalyst…”
Get full text