Search Results - "Dalotto‐Moreno, Tomás"

Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease by DALOTTO-MORENO, Tomás, CROCI, Diego O, SUNDBLAD, Victoria, RABINOVICH, Gabriel A, SALATINO, Mariana, CERLIANI, Juan P, MARTINEZ-ALLO, Veronica C, DERGAN-DYLON, Sebastián, MENDEZ-HUERGO, Santiago P, STUPIRSKI, Juan C, MAZAL, Daniel, OSINAGA, Eduardo, TOSCANO, Marta A

“…Galectin-1 (Gal1), an evolutionarily conserved glycan-binding protein, contributes to the creation of an immunosuppressed microenvironment at sites of tumor…”
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Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells by Bannoud, Nadia, Dalotto-Moreno, Tomás, Kindgard, Lucía, García, Pablo A, Blidner, Ada G, Mariño, Karina V, Rabinovich, Gabriel A, Croci, Diego O

“…Hypoxia, angiogenesis, and immunosuppression have been proposed to be interrelated events that fuel tumor progression and impair the clinical effectiveness of…”
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Hypothyroidism‐associated immunosuppression involves induction of galectin‐1‐producing regulatory T cells by Valli, Eduardo, Dalotto‐Moreno, Tomás, Sterle, Helena A., Méndez‐Huergo, Santiago P., Paulazo, María A., García, Silvia I., Pirola, Carlos J., Klecha, Alicia J., Rabinovich, Gabriel A., Cremaschi, Graciela A.

“…Hypothyroidism exerts deleterious effects on immunity, but the precise role of the hypothalamic–pituitary–thyroid (HPT) axis in immunoregulatory and…”
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Cdc42 localized in the CatSper signaling complex regulates cAMP‐dependent pathways in mouse sperm by Luque, Guillermina M., Xu, Xinran, Romarowski, Ana, Gervasi, María G., Orta, Gerardo, De la Vega‐Beltrán, José L., Stival, Cintia, Gilio, Nicolás, Dalotto‐Moreno, Tomás, Krapf, Dario, Visconti, Pablo E., Krapf, Diego, Darszon, Alberto, Buffone, Mariano G.

“…Sperm acquire the ability to fertilize in a process called capacitation and undergo hyperactivation, a change in the motility pattern, which depends on Ca2+…”
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Do galectins serve as soluble ligands for immune checkpoint receptors? by Torres, Nicolas I, Baudou, Federico G, Scheidegger, Marco A, Dalotto-Moreno, Tomás, Rabinovich, Gabriel A

“…Abstract…”
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Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk by Orozco, Carlos A., Martinez-Bosch, Neus, Guerrero, Pedro E., Vinaixa, Judith, Dalotto-Moreno, Tomás, Iglesias, Mar, Moreno, Mireia, Djurec, Magdolna, Poirier, Françoise, Gabius, Hans-Joachim, Fernandez-Zapico, Martin E., Hwang, Rosa F., Guerra, Carmen, Rabinovich, Gabriel A., Navarro, Pilar

“…Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to…”
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Suppression of age-related salivary gland autoimmunity by glycosylation-dependent galectin-1-driven immune inhibitory circuits by Allo, Verónica C. Martínez, Hauk, Vanesa, Sarbia, Nicolas, Pinto, Nicolás A., Croci, Diego O., Dalotto-Moreno, Tomás, Morales, Rosa M., Gatto, Sabrina G., Cocco, Montana N. Manselle, Stupirski, Juan C., Deladoey, Ángel, Maronna, Esteban, Marcaida, Priscila, Durigan, Virginia, Secco, Anastasia, Mamani, Marta, Dos Santos, Alicia, Pellet, Antonio Catalán, Leiros, Claudia Pérez, Rabinovich, Gabriel A., Toscano, Marta A.

“…Aging elicits quantitative and qualitative changes in different immune components, leading to disruption of tolerogenic circuits and development of autoimmune…”
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Concomitant inhibition of PPARγ and mTORC1 induces the differentiation of human monocytes into highly immunogenic dendritic cells by Erra Diaz, Fernando, Mazzitelli, Ignacio, Bleichmar, Lucía, Melucci, Claudia, Thibodeau, Asa, Dalotto Moreno, Tomás, Marches, Radu, Rabinovich, Gabriel A., Ucar, Duygu, Geffner, Jorge

“…Monocytes can differentiate into macrophages (Mo-Macs) or dendritic cells (Mo-DCs). The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF)…”
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Only a subpopulation of mouse sperm displays a rapid increase in intracellular calcium during capacitation by Luque, Guillermina M., Dalotto‐Moreno, Tomas, Martín‐Hidalgo, David, Ritagliati, Carla, Puga Molina, Lis C., Romarowski, Ana, Balestrini, Paula A., Schiavi‐Ehrenhaus, Liza J., Gilio, Nicolas, Krapf, Dario, Visconti, Pablo E., Buffone, Mariano G.

“…Mammalian sperm must undergo a functionally defined process called capacitation to be able to fertilize oocytes. They become capacitated in vivo by interacting…”
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Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression by Girotti, María Romina, Salatino, Mariana, Dalotto-Moreno, Tomás, Rabinovich, Gabriel A

“…Hanahan and Weinberg have proposed 10 organizing principles that enable growth and metastatic dissemination of cancer cells. These distinctive and…”
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Antibody- and T Cell-Dependent Responses Elicited by a SARS-CoV-2 Adenoviral-Based Vaccine in a Socially Vulnerable Cohort of Elderly Individuals by Moya, Martin, Marrama, Marcela, Dorazio, Carina, Veigas, Florencia, Manselle Cocco, Montana N., Dalotto Moreno, Tomas, Rabinovich, Gabriel A., Aleksandroff, Ariel

“…Background: In spite of compelling evidence demonstrating safety and immunogenicity of adenoviral-based SARS-CoV-2 vaccines in the general population, its…”
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Expansion of CD11b+Ly6G+Ly6Cint cells driven by medroxyprogesterone acetate in mice bearing breast tumors restrains NK cell effector functions by Spallanzani, Raúl Germán, Dalotto-Moreno, Tomás, Raffo Iraolagoitia, Ximena Lucía, Ziblat, Andrea, Domaica, Carolina Inés, Avila, Damián Ezequiel, Rossi, Lucas Ezequiel, Fuertes, Mercedes Beatriz, Battistone, María Agustina, Rabinovich, Gabriel Adrián, Salatino, Mariana, Zwirner, Norberto Walter

“…The progesterone analog medroxyprogesterone acetate (MPA) is widely used as a hormone replacement therapy in postmenopausal women and as contraceptive…”
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Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors by Croci, Diego O., Cerliani, Juan P., Dalotto-Moreno, Tomas, Méndez-Huergo, Santiago P., Mascanfroni, Ivan D., Dergan-Dylon, Sebastián, Toscano, Marta A., Caramelo, Julio J., García-Vallejo, Juan J., Ouyang, Jing, Mesri, Enrique A., Junttila, Melissa R., Bais, Carlos, Shipp, Margaret A., Salatino, Mariana, Rabinovich, Gabriel A.

“…The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted therapies is variable, and tumors from treated patients eventually…”
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Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid by Lehmann, Guillermo L, Hanke-Gogokhia, Christin, Hu, Yang, Bareja, Rohan, Salfati, Zelda, Ginsberg, Michael, Nolan, Daniel J, Mendez-Huergo, Santiago P, Dalotto-Moreno, Tomas, Wojcinski, Alexandre, Ochoa, Francisca, Zeng, Shemin, Cerliani, Juan P, Panagis, Lampros, Zager, Patrick J, Mullins, Robert F, Ogura, Shuntaro, Lutty, Gerard A, Bang, Jakyung, Zippin, Jonathan H, Romano, Carmelo, Rabinovich, Gabriel A, Elemento, Olivier, Joyner, Alexandra L, Rafii, Shahin, Rodriguez-Boulan, Enrique, Benedicto, Ignacio

“…The activity and survival of retinal photoreceptors depend on support functions performed by the retinal pigment epithelium (RPE) and on oxygen and nutrients…”
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Enhanced Antitumor Immunity via Endocrine Therapy Prevents Mammary Tumor Relapse and Increases Immune Checkpoint Blockade Sensitivity by Sequeira, Gonzalo R, Sahores, Ana, Dalotto-Moreno, Tomás, Perrotta, Ramiro M, Pataccini, Gabriela, Vanzulli, Silvia I, Polo, María L, Radisky, Derek C, Sartorius, Carol A, Novaro, Virginia, Lamb, Caroline A, Rabinovich, Gabriel A, Salatino, Mariana, Lanari, Claudia

“…The role of active antitumor immunity in hormone receptor-positive (HR ) breast cancer has been historically underlooked. The aim of this study was to…”
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Abstract 1840: Glycosylation of HER2+ human breast cancer cells control sensitivity to trastuzumab by Perrotta, Ramiro M., Dalotto-Moreno, Tomás, Cagnoni, Alejandro, Mariño, Karina, Rabinovich, Gabriel, Salatino, Mariana

“…Abstract Galectins decode glycan-containing information in a number of cell receptors adjusting signaling thresholds and modulating cellular functions. Upon…”
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Immunotherapy in cancer. Current prospects, challenges and new horizons by Dalotto-Moreno, Tomás, Blidner, Ada G, Girotti, M Romina, Maller, Sebastián M, Rabinovich, Gabriel A

“…Recent understanding of the mechanisms that control immune system homeostasis and orchestrate antitumor responses has prompted the development of novel…”
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Expansion of CD11b^sup +^Ly6G^sup +^Ly6C^sup int^ cells driven by medroxyprogesterone acetate in mice bearing breast tumors restrains NK cell effector functions by Spallanzani, Raúl Germán, Dalotto-moreno, Tomás, Raffo Iraolagoitia, Ximena Lucía, Ziblat, Andrea, Domaica, Carolina Inés, Avila, Damián Ezequiel, Rossi, Lucas Ezequiel, Fuertes, Mercedes Beatriz, Battistone, María Agustina, Rabinovich, Gabriel Adrián, Salatino, Mariana, Zwirner, Norberto Walter

“…The progesterone analog medroxyprogesterone acetate (MPA) is widely used as a hormone replacement therapy in postmenopausal women and as contraceptive…”
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Immunotherapy in cancer. Current prospects, challenges and new horizons by Dalotto-Moreno, Tomás, Blidner, Ada G, Girotti, M Romina, Maller, Sebastián M, Rabinovich, Gabriel A

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In vitro Regulatory T cells Differentiation From Naïve T Cells by Tomas Dalotto, Gabriel Rabinovich, Marian Salatino

“…In the past years, a subset of regulatory T cells (Tregs) expressing CD4, CD25 and the transcription factor FoxP3 has gained considerable attention as key…”
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