Search Results - "Dallmann, Robert"

Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy by Dallmann, Robert, Okyar, Alper, Lévi, Francis

“…Abstract Daily rhythms in physiology significantly modulate drug pharmacokinetics and pharmacodynamics according to the time-of-day, a finding that has led to…”
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Chronopharmacology: new insights and therapeutic implications by Dallmann, Robert, Brown, Steven A, Gachon, Frédéric

“…Most facets of mammalian physiology and behavior vary according to time of day, thanks to endogenous circadian clocks. Therefore, it is not surprising that…”
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Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics by Schmitt, Karen, Grimm, Amandine, Dallmann, Robert, Oettinghaus, Bjoern, Restelli, Lisa Michelle, Witzig, Melissa, Ishihara, Naotada, Mihara, Katsuyoshi, Ripperger, Jürgen A., Albrecht, Urs, Frank, Stephan, Brown, Steven A., Eckert, Anne

“…Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative phosphorylation and generation of ATP, are strongly…”
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human circadian metabolome by Dallmann, Robert, Viola, Antoine U, Tarokh, Leila, Cajochen, Christian, Brown, Steven A

“…The circadian clock orchestrates many aspects of human physiology, and disruption of this clock has been implicated in various pathologies, ranging from cancer…”
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Circadian behavior is light-reprogrammed by plastic DNA methylation by Azzi, Abdelhalim, Dallmann, Robert, Casserly, Alison, Rehrauer, Hubert, Patrignani, Andrea, Maier, Bert, Kramer, Achim, Brown, Steven A

“…In this study, the authors show that altering the photoperiod of mice results in reversible transcriptional and DNA methylation changes in the suprachiasmatic…”
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Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice by Jagannath, Aarti, Varga, Norbert, Dallmann, Robert, Rando, Gianpaolo, Gosselin, Pauline, Ebrahimjee, Farid, Taylor, Lewis, Mosneagu, Dragos, Stefaniak, Jakub, Walsh, Steven, Palumaa, Teele, Di Pretoro, Simona, Sanghani, Harshmeena, Wakaf, Zeinab, Churchill, Grant C., Galione, Antony, Peirson, Stuart N., Boison, Detlev, Brown, Steven A., Foster, Russell G., Vasudevan, Sridhar R.

“…The accumulation of adenosine is strongly correlated with the need for sleep and the detection of sleep pressure is antagonised by caffeine. Caffeine also…”
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TimeTeller: A tool to probe the circadian clock as a multigene dynamical system by Vlachou, Denise, Veretennikova, Maria, Usselmann, Laura, Vasilyev, Vadim, Ott, Sascha, Bjarnason, Georg A, Dallmann, Robert, Levi, Francis, Rand, David A

“…Recent studies have established that the circadian clock influences onset, progression and therapeutic outcomes in a number of diseases including cancer and…”
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Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Nonvolatile Drugs from Blood to Breath by Chen, Xing, Zhang, Keda, Yin, Zhihong, Fang, Mingliang, Pu, Weidan, Liu, Zhening, Li, Lei, Sinues, Pablo, Dallmann, Robert, Zhou, Zhen, Li, Xue

“…We used online secondary electrospray ionization mass spectrometry to measure venlafaxine (VEN), a nonvolatile drug, in the exhaled air of mice…”
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Circadian variation of the human metabolome captured by real-time breath analysis by Martinez-Lozano Sinues, Pablo, Tarokh, Leila, Li, Xue, Kohler, Malcolm, Brown, Steven A, Zenobi, Renato, Dallmann, Robert

“…Circadian clocks play a significant role in the correct timing of physiological metabolism, and clock disruption might lead to pathological changes of…”
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NQO1 protects against clioquinol toxicity by Chhetri, Jamuna, Dilek, Jem, Davies, Noel, Jacobson, Glenn, Dallmann, Robert, Gueven, Nuri

“…Clioquinol (CQ) was widely used as oral antibiotic before being taken off the market in many countries in 1970, after it was linked to subacute myelo-optic…”
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NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels by Haefeli, Roman H, Erb, Michael, Gemperli, Anja C, Robay, Dimitri, Courdier Fruh, Isabelle, Anklin, Corinne, Dallmann, Robert, Gueven, Nuri

“…Short-chain quinones are described as potent antioxidants and in the case of idebenone have already been under clinical investigation for the treatment of…”
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Disturbed Yin–Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1 by Yan, Chang, Luo, Zhuo, Li, Wen, Li, Xue, Dallmann, Robert, Kurihara, Hiroshi, Li, Yi-Fang, He, Rong-Rong

“…Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary…”
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Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath by Li, Xue, Martinez-Lozano Sinues, Pablo, Dallmann, Robert, Bregy, Lukas, Hollmén, Maija, Proulx, Steven, Brown, Steven A., Detmar, Michael, Kohler, Malcolm, Zenobi, Renato

“…Noninvasive, real‐time pharmacokinetic (PK) monitoring of ketamine, propofol, and valproic acid, and their metabolites was achieved in mice, using secondary…”
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The Hepatic Circadian Clock Modulates Xenobiotic Metabolism in Mice by DeBruyne, Jason P., Weaver, David R., Dallmann, Robert

“…The circadian clock generates daily cycles of gene expression that regulate physiological processes. The liver plays an important role in xenobiotic metabolism…”
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CRH-R2 signalling modulates feeding and circadian gene expression in hypothalamic mHypoA-2/30 neurons by Alcántara-Alonso, Viridiana, Dallmann, Robert, Lehnert, Hendrik, de Gortari, Patricia, Grammatopoulos, Dimitris K.

“…The hypothalamic type 2 corticotropin releasing hormone receptor (CRH-R2) plays critical roles in homeostatic regulation, particularly in fine tuning stress…”
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Tick-Tock Consider the Clock: The Influence of Circadian and External Cycles on Time of Day Variation in the Human Metabolome-A Review by Hancox, Thomas P M, Skene, Debra J, Dallmann, Robert, Dunn, Warwick B

“…The past decade has seen a large influx of work investigating time of day variation in different human biofluid and tissue metabolomes. The driver of this…”
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Low-Cost Microfabrication Tool Box by Charmet, Jérôme, Rodrigues, Rui, Yildirim, Ender, Challa, Pavan Kumar, Roberts, Benjamin, Dallmann, Robert, Whulanza, Yudan

“…Microsystems are key enabling technologies, with applications found in almost every industrial field, including in vitro diagnostic, energy harvesting,…”
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Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice by Bergamini, Giorgio, Mechtersheimer, Jonas, Azzinnari, Damiano, Sigrist, Hannes, Buerge, Michaela, Dallmann, Robert, Freije, Robert, Kouraki, Afroditi, Opacka-Juffry, Jolanta, Seifritz, Erich, Ferger, Boris, Suter, Tobias, Pryce, Christopher R.

“…Psychosocial stress is a major risk factor for depression, stress leads to peripheral and central immune activation, immune activation is associated with…”
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Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection by Taylor, Lewis, Von Lendenfeld, Felix, Ashton, Anna, Sanghani, Harshmeena, Di Pretoro, Simona, Usselmann, Laura, Veretennikova, Maria, Dallmann, Robert, McKeating, Jane A., Vasudevan, Sridhar, Jagannath, Aarti

“…Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2…”
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Circadian rest‐activity rhythm as an objective biomarker of patient‐reported outcomes in patients with advanced cancer by Innominato, Pasquale F., Komarzynski, Sandra, Palesh, Oxana G., Dallmann, Robert, Bjarnason, Georg A., Giacchetti, Sylvie, Ulusakarya, Ayhan, Bouchahda, Mohamed, Haydar, Mazen, Ballesta, Annabelle, Karaboué, Abdoulaye, Wreglesworth, Nicholas I., Spiegel, David, Lévi, Francis A.

“…Background Psychosocial symptoms often cluster together, are refractory to treatment, and impair health‐related quality of life (HR‐QoL) in cancer patients…”
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