Effects of neonatal sepsis on thrombocyte tests
Objective: Hemostatic disorders are common complications in sepsis, and coagulation abnormalities occur in almost all the septic patients. Thrombocytes have a key role in the pathogenesis of coagulation abnormalities in sepsis. This study aimed to investigate thrombocyte function disorders as a like...
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| Published in: | The journal of maternal-fetal & neonatal medicine Vol. 29; no. 9; pp. 1406 - 1408 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Taylor & Francis
02-05-2016
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Objective: Hemostatic disorders are common complications in sepsis, and coagulation abnormalities occur in almost all the septic patients. Thrombocytes have a key role in the pathogenesis of coagulation abnormalities in sepsis. This study aimed to investigate thrombocyte function disorders as a likely cause of hemorrhagic diathesis in patients with neonatal sepsis.
Material and methods: The study included 70 septic newborns (sepsis group) and 59 healthy newborns (control group). Blood samples were collected from the patients within the first 24 h of hospitalization. Thrombocyte aggregation and secretion tests were performed by optical aggregometry and lumi-aggregometry, respectively. Collagen (2 μg/mL), epinephrine (5 μM), standard (5 μM) and high (10 μM) doses of adenosine diphosphate (ADP), standard (1 unit) and high (4 units) doses of thrombin, ristocetin (1.25 mg/mL) and arachidonic acid (0.5 mM) were used as the agonists.
Results: The mean age of the septic newborns was significantly higher than that of the controls (6.78 ± 14.47 days versus 1.25 ± 1.17, p < 0.001). There was no difference between the groups regarding gender- and birth-related characteristics. No difference was observed between the groups regarding platelet count (293.37 ± 144.48 × 10
9
/L in the sepsis group and 254.22 ± 65.26 × 10
9
/L in the control group, p = 0.195). Platelet secretion induced by collagen, epinephrine, standard and high (10 μM) doses of ADP, or arachidonic acid and platelet aggregation induced by collagen, high-dose ADP, arachidonic acid, ristocetin or thrombin (1 unit) were significantly higher in the sepsis group than in the control group.
Conclusion: Based on the results, we concluded that large-scale studies with recurrent tests performed in different periods of sepsis are needed. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1476-7058 1476-4954 |
| DOI: | 10.3109/14767058.2015.1049523 |