Oxygen therapy alternatives in COVID-19: From classical to nanomedicine

Around 10–15% of COVID-19 patients affected by the Delta and the Omicron variants exhibit acute respiratory insufficiency and require intensive care unit admission to receive advanced respiratory support. However, the current ventilation methods display several limitations, including lung injury, dy...

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Bibliographic Details
Published in:	Heliyon Vol. 9; no. 4; p. e15500
Main Authors:	Pereira, Luis F.T., Dallagnol, Camila A., Moulepes, Tassiana H., Hirota, Clara Y., Kutsmi, Pedro, dos Santos, Lucas V., Pirich, Cleverton L., Picheth, Guilherme F.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-04-2023 Published by Elsevier Ltd Elsevier
Subjects:	COVID-19 Hypoxia Microbubbles Nanobubbles Nanotechnology Oxygen therapy Review COVID-19 Microbubbles Hypoxia Nanobubbles Oxygen therapy Nanotechnology
Online Access:	Get full text
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Summary:	Around 10–15% of COVID-19 patients affected by the Delta and the Omicron variants exhibit acute respiratory insufficiency and require intensive care unit admission to receive advanced respiratory support. However, the current ventilation methods display several limitations, including lung injury, dysphagia, respiratory muscle atrophy, and hemorrhage. Furthermore, most of the ventilatory techniques currently offered require highly trained professionals and oxygen cylinders, which may attain short supply owing to the high demand and misuse. Therefore, the search for new alternatives for oxygen therapeutics has become extremely important for maintaining gas exchange in patients affected by COVID-19. This review highlights and suggest new alternatives based on micro and nanostructures capable of supplying oxygen and/or enabling hematosis during moderate or acute COVID-19 cases. [Display omitted]
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	2405-8440 2405-8440
DOI:	10.1016/j.heliyon.2023.e15500