Search Results - "Dall’Angelo, Sergio"

Metal‐free phthalimide‐labeled peptide nucleic acids for electrochemical biosensing applications by Magni, Mirko, Dall'Angelo, Sergio, Baldoli, Clara, Licandro, Emanuela, Falciola, Luigi, Mussini, Patrizia R.

“…Peptide nucleic acids (PNAs) are neutral mimics of natural DNA and RNA biopolymers that have caught the attention of researchers working on the identification…”
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The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2 by Thompson, Karen J., Watson, Sonia, Zanato, Chiara, Dall'Angelo, Sergio, De Nooij, Joriene C., Pace‐Bonello, Bethany, Shenton, Fiona C., Sanger, Helen E., Heinz, Beverly A., Broad, Lisa M., Grosjean, Noelle, McQuillian, Jessica R., Dubini, Marina, Pyner, Susan, Greig, Iain, Zanda, Matteo, Bleakman, David, Banks, Robert W., Bewick, Guy S.

“…A metabotropic glutamate receptor coupled to phospholipase D (PLD‐mGluR) was discovered in the hippocampus over three decades ago. Its pharmacology and direct…”
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[18F]-5-Fluoro-5-deoxyribose, an efficient peptide bioconjugation ligand for positron emission tomography (PET) imaging by Li, Xiang-Guo, Dall'Angelo, Sergio, Schweiger, Lutz F, Zanda, Matteo, O'Hagan, David

“…[(18)F]-5-Fluoro-5-deoxyribose ([(18)F]-FDR) conjugates much more rapidly than [(18)F]-FDG under mild reaction conditions to peptides and offers new prospects…”
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A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms by Schaefer, Katja, Dambuza, Ivy M, Dall'Angelo, Sergio, Yuecel, Raif, Jaspars, Marcel, Trembleau, Laurent, Zanda, Matteo, Brown, Gordon D, Netea, Mihai G, Gow, Neil A R

“…The discovery of liquid water at several locations in the solar system raises the possibility that microbial life may have evolved outside Earth and as such…”
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Protein tyrosine phosphatase 1B in metabolic diseases and drug development by Delibegović, Mirela, Dall’Angelo, Sergio, Dekeryte, Ruta

“…Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signalling pathways, including direct negative…”
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Protection of Sinorhizobium against host cysteine-rich antimicrobial peptides is critical for symbiosis by Haag, Andreas F, Baloban, Mikhail, Sani, Monica, Kerscher, Bernhard, Pierre, Olivier, Farkas, Attila, Longhi, Renato, Boncompagni, Eric, Hérouart, Didier, Dall'angelo, Sergio, Kondorosi, Eva, Zanda, Matteo, Mergaert, Peter, Ferguson, Gail P

“…Sinorhizobium meliloti differentiates into persisting, nitrogen-fixing bacteroids within root nodules of the legume Medicago truncatula. Nodule-specific…”
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Clinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer by Alwadani, Bandar, Dall’Angelo, Sergio, Fleming, Ian N.

“…Lung cancer has the highest mortality rate of any tumour type. The main driver of lung tumour growth and development is uncontrolled cellular proliferation…”
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The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators by Tseng, Chih-Chung, Baillie, Gemma, Donvito, Giulia, Mustafa, Mohammed A, Juola, Sophie E, Zanato, Chiara, Massarenti, Chiara, Dall’Angelo, Sergio, Harrison, William T. A, Lichtman, Aron H, Ross, Ruth A, Zanda, Matteo, Greig, Iain R

“…The first generation of CB1 positive allosteric modulators (e.g., ZCZ011) featured a 3-nitroalkyl-2-phenyl-indole structure. Although a small number of drugs…”
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NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting by Graziadio, Alessandra, Zanda, Matteo, Frau, Simona, Fleming, Ian N, Musolino, Manuele, Dall’Angelo, Sergio, Baldassarre, Massimiliano, Piras, Monica

“…Cyclic CNGRC (cCNGRC) peptides are very important targeting ligands for Aminopeptidase N (APN or CD13), which is overexpressed on the surface of many cancer…”
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Synthesis of hydrazino-peptide nucleic acid monomers and dimers as new PNA backbone building blocks by Cerea, Paolangelo, Giannini, Clelia, Dall'Angelo, Sergio, Licandro, Emanuela, Maiorana, Stefano, Marchelli, Rosangela

“…We describe the synthesis of new hydrazinoPNA ( hydPNA) monomers and new hydPNA-containing dimers. For the hydPNA monomers, the primary terminal amino group of…”
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Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status by Andriu, Alexandra, Crockett, Julie, Dall’Angelo, Sergio, Piras, Monica, Zanda, Matteo, Fleming, Ian N.

“…Purpose Molecular imaging of α v β 3 integrin has exhibited real potential to guide the appropriate use of anti-angiogenic therapies. However, an incomplete…”
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Design, Synthesis, Conjugation, and Reactivity of Novel trans,trans-1,5-Cyclooctadiene-Derived Bioorthogonal Linkers by Longo, Beatrice, Zanato, Chiara, Piras, Monica, Dall’Angelo, Sergio, Windhorst, Albert D, Vugts, Danielle J, Baldassarre, Massimiliano, Zanda, Matteo

“…The tetrazine/trans-cyclooctene (TCO) inverse electron-demand Diels–Alder (IEDDA) reaction is the fastest bioorthogonal “click” ligation process reported to…”
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Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters by Testa, Andrea, Dall’Angelo, Sergio, Mingarelli, Marco, Augello, Andrea, Schweiger, Lutz, Welch, Andy, Elmore, Charles S., Sharma, Pradeep, Zanda, Matteo

“…[Display omitted] With the aim of identifying a fluorinated bile acid derivative that could be used as [18F]-labeled Positron Emission Tomography (PET) tracer…”
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Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters by Zanda, Matteo, Sharma, Pradeep, Elmore, Charles S., Welch, Andrew, Schweiger, Lutz, Augello, Andrea, Mingarelli, Marco, Dall’Angelo, Sergio, Testa, Andrea, Dawson, Dana

“…The bile acid analogue [18F]LCATD (LithoCholic Acid Triazole Derivative) is transported in vitro by hepatic uptake transporters such as OATP1B1 and NTCP and…”
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[18F]ZCDD083: A PFKFB3-Targeted PET Tracer for Atherosclerotic Plaque Imaging by De Dominicis, Carlo, Perrotta, Paola, Dall’Angelo, Sergio, Wyffels, Leonie, Staelens, Steven, De Meyer, G. R. Y, Zanda, Matteo

“…PFKFB3, a glycolysis-related enzyme upregulated in inflammatory conditions and angiogenesis, is an emerging target for diagnosis and therapy of…”
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The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB 1 Receptor Positive Allosteric Modulators by Tseng, Chih-Chung, Baillie, Gemma, Donvito, Giulia, Mustafa, Mohammed A, Juola, Sophie E, Zanato, Chiara, Massarenti, Chiara, Dall'Angelo, Sergio, Harrison, William T A, Lichtman, Aron H, Ross, Ruth A, Zanda, Matteo, Greig, Iain R

“…The first generation of CB positive allosteric modulators (e.g., ZCZ011) featured a 3-nitroalkyl-2-phenyl-indole structure. Although a small number of drugs…”
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Chemoenzymatic Late‐Stage Modifications Enable Downstream Click‐Mediated Fluorescent Tagging of Peptides by Colombano, Alessandro, Dalponte, Luca, Dall'Angelo, Sergio, Clemente, Claudia, Idress, Mohannad, Ghazal, Ahmad, Houssen, Wael E.

“…Aromatic prenyltransferases from cyanobactin biosynthetic pathways catalyse the chemoselective and regioselective intramolecular transfer of prenyl/geranyl…”
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Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA by Hernandez‐Gerez, Elena, Dall’Angelo, Sergio, Collinson, Jon M., Fleming, Ian N., Parson, Simon H.

“…Objective The purpose of the study was to determine the extent and role of systemic hypoxia in the pathogenesis of spinal muscular atrophy (SMA). Methods…”
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Enzymatic Fluorination of Biotin and Tetrazine Conjugates for Pretargeting Approaches to Positron Emission Tomography Imaging by Lowe, Phillip T., Dall'Angelo, Sergio, Devine, Andrew, Zanda, Matteo, O'Hagan, David

“…The use of radiolabelled antibodies and antibody‐derived recombinant constructs has shown promise for both imaging and therapeutic use. In this context, the…”
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Synthesis, Radiosynthesis, and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR by Musolino, Manuele, Fleming, Ian N., Schweiger, Lutz F., O'Hagan, David, Dall'Angelo, Sergio, Zanda, Matteo

“…We report the synthesis of five radiotracers incorporating different oxyamine spacers between the hypoxia‐reactive 2‐nitroimidazole moiety and the…”
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