Search Results - "Dalin, Martin G."
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Antioxidants can increase melanoma metastasis in mice
Published in Science translational medicine (07-10-2015)“…Antioxidants in the diet and supplements are widely used to protect against cancer, but clinical trials with antioxidants do not support this concept. Some…”
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The Immune Microenvironment and Neoantigen Landscape of Aggressive Salivary Gland Carcinomas Differ by Subtype
Published in Clinical cancer research (15-06-2020)“…Salivary gland carcinomas (SGC) are rare, aggressive cancers with high rates of recurrence and distant metastasis. These factors, and a lack of active systemic…”
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The head and neck cancer immune landscape and its immunotherapeutic implications
Published in JCI insight (20-10-2016)“…Recent clinical trials have demonstrated a clear survival advantage in advanced head and neck squamous cell carcinoma (HNSCC) patients treated with immune…”
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Comprehensive Molecular Characterization of Salivary Duct Carcinoma Reveals Actionable Targets and Similarity to Apocrine Breast Cancer
Published in Clinical cancer research (15-09-2016)“…Salivary duct carcinoma (SDC) is an aggressive salivary malignancy, which is resistant to chemotherapy and has high mortality rates. We investigated the…”
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An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis
Published in Cell reports (Cambridge) (15-08-2017)“…At the root of most fatal malignancies are aberrantly activated transcriptional networks that drive metastatic dissemination. Although…”
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Circulating cell-free tumor DNA analysis in pediatric cancers
Published in Molecular aspects of medicine (01-04-2020)“…Analysis of circulating cell-free tumor DNA (ctDNA) has shown promising results within several clinical applications, including cancer detection, mutation…”
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Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma
Published in The Journal of clinical investigation (01-10-2019)“…BACKGROUNDAdenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by high rates of relapse and distant…”
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Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions
Published in Nature communications (30-10-2017)“…Myoepithelial carcinoma (MECA) is an aggressive salivary gland cancer with largely unknown genetic features. Here we comprehensively analyze molecular…”
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Androgen Receptor Signaling in Salivary Gland Cancer
Published in Cancers (08-02-2017)“…Salivary gland cancers comprise a small subset of human malignancies, and are classified into multiple subtypes that exhibit diverse histology, molecular…”
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Massive parallel sequencing questions the pathogenic role of missense variants in dilated cardiomyopathy
Published in International journal of cardiology (01-02-2017)“…Abstract Background Germline genetic variants are an important cause of dilated cardiomyopathy (DCM). However, recent sequencing studies have revealed rare…”
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Myocardial KRAS(G12D) expression does not cause cardiomyopathy in mice
Published in Cardiovascular research (01-02-2014)“…Germ-line mutations in genes encoding components of the RAS/mitogen-activated protein kinase (MAPK) pathway cause developmental disorders called RASopathies…”
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Immunogenic neoantigens derived from gene fusions stimulate T cell responses
Published in Nature medicine (01-05-2019)“…Anti-tumor immunity is driven by self versus non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens…”
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Myocardial KRASG12D expression does not cause cardiomyopathy in mice
Published in Cardiovascular research (01-02-2014)“…AimsGerm-line mutations in genes encoding components of the RAS/mitogen-activated protein kinase (MAPK) pathway cause developmental disorders called…”
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