Search Results - "Daley, Mark"

Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues by Soepriatna, Arvin H, Navarrete-Welton, Allison, Kim, Tae Yun, Daley, Mark C, Bronk, Peter, Kofron, Celinda M, Mende, Ulrike, Coulombe, Kareen L K, Choi, Bum-Rak

“…Recent advances in human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues provide a unique opportunity for cardiotoxic assessment of…”
Get full text

In vitro to in vivo extrapolation from 3D hiPSC-derived cardiac microtissues and physiologically based pharmacokinetic modeling to inform next-generation arrhythmia risk assessment by Daley, Mark C, Moreau, Marjory, Bronk, Peter, Fisher, Jeffrey, Kofron, Celinda M, Mende, Ulrike, McMullen, Patrick, Choi, Bum-Rak, Coulombe, Kareen

“…Abstract Proarrhythmic cardiotoxicity remains a substantial barrier to drug development as well as a major global health challenge. In vitro human pluripotent…”
Get full text

Neural network models of the tactile system develop first-order units with spatially complex receptive fields by Zhao, Charlie W, Daley, Mark J, Pruszynski, J Andrew

“…First-order tactile neurons have spatially complex receptive fields. Here we use machine-learning tools to show that such complexity arises for a wide range of…”
Get full text

Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing by Daley, Mark C, Mende, Ulrike, Choi, Bum-Rak, McMullen, Patrick D, Coulombe, Kareen L K

“…Environmental factors play a substantial role in determining cardiovascular health, but data informing the risks presented by environmental toxicants is…”
Get full text

"AI's gonna have an impact on everything in society, so it has to have an impact on public health": a fundamental qualitative descriptive study of the implications of artificial intelligence for public health by Morgenstern, Jason D, Rosella, Laura C, Daley, Mark J, Goel, Vivek, Schünemann, Holger J, Piggott, Thomas

“…Our objective was to determine the impacts of artificial intelligence (AI) on public health practice. We used a fundamental qualitative descriptive study…”
Get full text

Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism by Patel, Maitray A, Knauer, Michael J, Nicholson, Michael, Daley, Mark, Van Nynatten, Logan R, Martin, Claudio, Patterson, Eric K, Cepinskas, Gediminas, Seney, Shannon L, Dobretzberger, Verena, Miholits, Markus, Webb, Brian, Fraser, Douglas D

“…Long-COVID is characterized by prolonged, diffuse symptoms months after acute COVID-19. Accurate diagnosis and targeted therapies for Long-COVID are lacking…”
Get full text

The plasma proteome differentiates the multisystem inflammatory syndrome in children (MIS-C) from children with SARS-CoV-2 negative sepsis by Patel, Maitray A, Fraser, Douglas D, Daley, Mark, Cepinskas, Gediminas, Veraldi, Noemi, Grazioli, Serge

“…The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct treatment protocol…”
Get full text

Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients by Fraser, Douglas D, Cepinskas, Gediminas, Slessarev, Marat, Martin, Claudio, Daley, Mark, Miller, Michael R, O'Gorman, David B, Gill, Sean E, Patterson, Eric K, Dos Santos, Claudia C

“…Coronavirus disease 2019 is caused by severe acute respiratory syndrome-coronavirus-2 infection to which there is no community immunity. Patients admitted to…”
Get full text

Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning by Patel, Maitray A, Knauer, Michael J, Nicholson, Michael, Daley, Mark, Van Nynatten, Logan R, Cepinskas, Gediminas, Fraser, Douglas D

“…Survivors of acute COVID-19 often suffer prolonged, diffuse symptoms post-infection, referred to as "Long-COVID". A lack of Long-COVID biomarkers and…”
Get full text

Classification of lidar measurements using supervised and unsupervised machine learning methods by Farhani, Ghazal, Sica, Robert J, Daley, Mark Joseph

“…While it is relatively straightforward to automate the processing of lidar signals, it is more difficult to choose periods of “good” measurements to process…”
Get full text

A novel multiplex biomarker panel for profiling human acute and chronic kidney disease by Van Nynatten, Logan R., Miller, Michael R., Patel, Maitray A., Daley, Mark, Filler, Guido, Badrnya, Sigrun, Miholits, Markus, Webb, Brian, McIntyre, Christopher W., Fraser, Douglas D.

“…Acute and chronic kidney disease continues to confer significant morbidity and mortality in the clinical setting. Despite high prevalence of these conditions,…”
Get full text

The Sticky Riff: Quantifying the Melodic Identities of Medieval Modes by Helsen, Kate, Daley, Mark, Schindler, Jake

“…Andrew Hughes' Late Medieval Liturgical Offices afforded chant scholarship more melodies than it knew what to do with. Until now, chant scholarship involving…”
Get full text

The effects of membrane potential and extracellular matrix composition on vascular differentiation of cardiac progenitor cells by Daley, Mark C., Bonzanni, Mattia, MacKenzie, Allison M., Kaplan, David L., Black, Lauren D.

“…Historically, the field of tissue engineering has been adept at modulating the chemical and physical microenvironment. This approach has yielded significant…”
Get full text

Endothelial Injury and Glycocalyx Degradation in Critically Ill Coronavirus Disease 2019 Patients: Implications for Microvascular Platelet Aggregation by Fraser, Douglas D, Patterson, Eric K, Slessarev, Marat, Gill, Sean E, Martin, Claudio, Daley, Mark, Miller, Michael R, Patel, Maitray A, Dos Santos, Claudia C, Bosma, Karen J, O'Gorman, David B, Cepinskas, Gediminas

“…Coronavirus disease 2019 is caused by the novel severe acute respiratory syndrome coronavirus 2 virus. Patients admitted to the ICU suffer from microvascular…”
Get full text

Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores by Leonard, Sean, Guertin, Hailey, Odoardi, Natalya, Miller, Michael R, Patel, Maitray A, Daley, Mark, Cepinskas, Gediminas, Fraser, Douglas D

“…Sepsis is a dysregulated systemic inflammatory response triggered by infection, resulting in organ dysfunction. A major challenge in clinical pediatrics is to…”
Get full text

Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers by Fraser, Douglas D, Slessarev, Marat, Martin, Claudio M, Daley, Mark, Patel, Maitray A, Miller, Michael R, Patterson, Eric K, O'Gorman, David B, Gill, Sean E, Wishart, David S, Mandal, Rupasri, Cepinskas, Gediminas

“…Coronavirus disease 2019 continues to spread rapidly with high mortality. We performed metabolomics profiling of critically ill coronavirus disease 2019…”
Get full text

Case Report: Inflammation and Endothelial Injury Profiling of COVID-19 Pediatric Multisystem Inflammatory Syndrome (MIS-C) by Fraser, Douglas D, Patterson, Eric K, Daley, Mark, Cepinskas, Gediminas

“…COVID-19 is associated with a novel multi-system inflammatory syndrome that shares some characteristics with Kawasaki's Disease. The syndrome manifestation is…”
Get full text

Characterization of cardiac fibroblast-extracellular matrix crosstalk across developmental ages provides insight into age-related changes in cardiac repair by Perreault, Luke R, Daley, Mark C, Watson, Matthew C, Rastogi, Sagar, Jaiganesh, Ajith, Porter, Elizabeth C, Duffy, Breanna M, Black, 3rd, Lauren D

“…Heart failure afflicts an estimated 6.5 million people in the United States, driven largely by incidents of coronary heart disease (CHD). CHD leads to heart…”
Get full text

Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes by Xu, Xiaoyun, Cowan, Matthew, Beraldo, Flavio, Schranz, Amy, McCunn, Patrick, Geremia, Nicole, Brown, Zalman, Patel, Maitray, Nygard, Karen L, Khazaee, Reza, Lu, Lihong, Liu, Xingyu, Strong, Michael J, Dekaban, Gregory A, Menon, Ravi, Bartha, Robert, Daley, Mark, Mao, Haojie, Prado, Vania, Prado, Marco A M, Saksida, Lisa, Bussey, Tim, Brown, Arthur

“…We have previously reported long-term changes in the brains of non-concussed varsity rugby players using magnetic resonance spectroscopy (MRS), diffusion…”
Get full text

One Billion hiPSC-Cardiomyocytes: Upscaling Engineered Cardiac Tissues to Create High Cell Density Therapies for Clinical Translation in Heart Regeneration by Dwyer, Kiera D, Kant, Rajeev J, Soepriatna, Arvin H, Roser, Stephanie M, Daley, Mark C, Sabe, Sharif A, Xu, Cynthia M, Choi, Bum-Rak, Sellke, Frank W, Coulombe, Kareen L K

“…Despite the overwhelming use of cellularized therapeutics in cardiac regenerative engineering, approaches to biomanufacture engineered cardiac tissues (ECTs)…”
Get full text