Search Results - "Daley, Heather"

Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: A Phase I Clinical Trial by Exley, Mark A, Friedlander, Phillip, Alatrakchi, Nadia, Vriend, Lianne, Yue, Simon, Sasada, Tetsuro, Zeng, Wanyong, Mizukami, Yo, Clark, Justice, Nemer, David, LeClair, Kenneth, Canning, Christine, Daley, Heather, Dranoff, Glenn, Giobbie-Hurder, Anita, Hodi, F Stephen, Ritz, Jerome, Balk, Steven P

“…Invariant NKT cells (iNKT) are innate-like CD1d-restricted T cells with immunoregulatory activity in diseases including cancer. iNKT from advanced cancer…”
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825-P: Novel Autologous Dendritic Cell Therapy AVT001 for Type 1 Diabetes by GAGLIA, JASON L., MACKEY, MIKAYLA, DALEY, HEATHER L., BRYANT, NORA, KIM, DAVID Y., DONG, TUOCHUAN, FAN, ERMEI E., VORA, JITEN, SKYLER, JAY S., RITZ, JEROME, JIANG, HONG

“…Studies in several animal models and of humans with type 1 diabetes (T1D) have suggested that Qa-1/HLA-E restricted CD8+ T regulatory cells (Tregs) are…”
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A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome by Hammond, Terese C., Purbhoo, Marco A., Kadel, Sapana, Ritz, Jerome, Nikiforow, Sarah, Daley, Heather, Shaw, Kit, van Besien, Koen, Gomez-Arteaga, Alexandra, Stevens, Don, Ortuzar, Waldo, Michelet, Xavier, Smith, Rachel, Moskowitz, Darrian, Masakayan, Reed, Yigit, Burcu, Boi, Shannon, Soh, Kah Teong, Chamberland, John, Song, Xin, Qin, Yu, Mishchenko, Ilya, Kirby, Maurice, Nasonenko, Valeriia, Buffa, Alexa, Buell, Jennifer S., Chand, Dhan, van Dijk, Marc, Stebbing, Justin, Exley, Mark A.

“…Invariant natural killer T (iNKT) cells, a unique T cell population, lend themselves for use as adoptive therapy due to diverse roles in orchestrating immune…”
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Phase II trial of vaccination with autologous, irradiated melanoma cells engineered by adenoviral mediated gene transfer to secrete granulocyte-macrophage colony stimulating factor in patients with stage III and IV melanoma by Sussman, Tamara A, Severgnini, Mariano, Giobbie-Hurder, Anita, Friedlander, Philip, Swanson, Scott J, Jaklitsch, Michael, Clancy, Thomas, Goguen, Laura A, Lautz, David, Swanson, Richard, Daley, Heather, Ritz, Jerome, Dranoff, Glenn, Hodi, F Stephen

“…In the era of immune checkpoint blockade, the role of cancer vaccines in immune priming has provided additional potential for therapeutic improvements. Prior…”
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Novel Autologous Dendritic Cell Therapy AVT001 for Type 1 Diabetes by Gaglia, Jason L, Daley, Heather L, Bryant, Nora K, Ritz, Jerome, Dong, Tuochuan, Skyler, Jay S, Jiang, Hong

“…CD8+ T regulatory (Treg) cells that recognize the nonclassical class 1b molecule Qa-1/human leukocyte antigen E (Q/E CD8+ Treg cells) are important in…”
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A phase I study of CD25/regulatory T-cell-depleted donor lymphocyte infusion for relapse after allogeneic stem cell transplantation by Nikiforow, Sarah, Kim, Haesook T, Daley, Heather, Reynolds, Carol, Jones, Kyle Thomas, Armand, Philippe, Ho, Vincent T, Alyea, 3rd, Edwin P, Cutler, Corey S, Ritz, Jerome, Antin, Joseph H, Soiffer, Robert J, Koreth, John

“…Donor lymphocyte infusions are used to treat relapse after allogeneic hematopoietic stem cell transplantation, but responses are inadequate. In addition to…”
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Vaccination with autologous myeloblasts admixed with GM-K562 cells in patients with advanced MDS or AML after allogeneic HSCT by Ho, Vincent T., Kim, Haesook T., Bavli, Natalie, Mihm, Martin, Pozdnyakova, Olga, Piesche, Matthias, Daley, Heather, Reynolds, Carol, Souders, Nicholas C., Cutler, Corey, Koreth, John, Alyea, Edwin P., Antin, Joseph H., Ritz, Jerome, Dranoff, Glenn, Soiffer, Robert J.

“…We report a clinical trial testing vaccination of autologous myeloblasts admixed with granulocyte-macrophage colony-stimulating factor secreting K562 cells…”
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Immunization Using Autologous Dendritic Cells Pulsed with the Melanoma-Associated Antigen gp100-Derived G280-9V Peptide Elicits CD8+ Immunity by Linette, Gerald P, Zhang, Dongsheng, Hodi, F Stephen, Jonasch, Eric P, Longerich, Simonne, Stowell, Christopher P, Webb, Iain J, Daley, Heather, Soiffer, Robert J, Cheung, Amy M, Eapen, Sara G, Fee, Sharon V, Rubin, Krista M, Sober, Arthur J, Haluska, Frank G

“…Purpose: To determine the toxicity, maximal tolerated dose, and clinical and immunologic response to autologous dendritic cells pulsed with melanoma-associated…”
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High density electromyography data of normally limbed and transradial amputee subjects for multifunction prosthetic control by Daley, Heather, Englehart, Kevin, Hargrove, Levi, Kuruganti, Usha

“…Abstract Pattern recognition based control of powered upper limb myoelectric prostheses offers a means of extracting more information from the available…”
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Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease by Esrick, Erica B, Lehmann, Leslie E, Biffi, Alessandra, Achebe, Maureen, Brendel, Christian, Ciuculescu, Marioara F, Daley, Heather, MacKinnon, Brenda, Morris, Emily, Federico, Amy, Abriss, Daniela, Boardman, Kari, Khelladi, Radia, Shaw, Kit, Negre, Helene, Negre, Olivier, Nikiforow, Sarah, Ritz, Jerome, Pai, Sung-Yun, London, Wendy B, Dansereau, Colleen, Heeney, Matthew M, Armant, Myriam, Manis, John P, Williams, David A

“…The switch from fetal to adult hemoglobin expression in humans is related to the active repression of HbF expression by BCL11A . A self-inactivating lentivirus…”
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An immunogenic personal neoantigen vaccine for patients with melanoma by Ott, Patrick A., Hu, Zhuting, Keskin, Derin B., Shukla, Sachet A., Sun, Jing, Bozym, David J., Zhang, Wandi, Luoma, Adrienne, Giobbie-Hurder, Anita, Peter, Lauren, Chen, Christina, Olive, Oriol, Carter, Todd A., Li, Shuqiang, Lieb, David J., Eisenhaure, Thomas, Gjini, Evisa, Stevens, Jonathan, Lane, William J., Javeri, Indu, Nellaiappan, Kaliappanadar, Salazar, Andres M., Daley, Heather, Seaman, Michael, Buchbinder, Elizabeth I., Yoon, Charles H., Harden, Maegan, Lennon, Niall, Gabriel, Stacey, Rodig, Scott J., Barouch, Dan H., Aster, Jon C., Getz, Gad, Wucherpfennig, Kai, Neuberg, Donna, Ritz, Jerome, Lander, Eric S., Fritsch, Edward F., Hacohen, Nir, Wu, Catherine J.

“…The results of a phase I trial assessing a personal neoantigen multi-peptide vaccine in patients with melanoma, showing feasibility, safety, and…”
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Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial by Keskin, Derin B., Anandappa, Annabelle J., Sun, Jing, Tirosh, Itay, Mathewson, Nathan D., Li, Shuqiang, Oliveira, Giacomo, Giobbie-Hurder, Anita, Felt, Kristen, Gjini, Evisa, Shukla, Sachet A., Hu, Zhuting, Li, Letitia, Le, Phuong M., Allesøe, Rosa L., Richman, Alyssa R., Kowalczyk, Monika S., Abdelrahman, Sara, Geduldig, Jack E., Charbonneau, Sarah, Pelton, Kristine, Iorgulescu, J. Bryan, Elagina, Liudmila, Zhang, Wandi, Olive, Oriol, McCluskey, Christine, Olsen, Lars R., Stevens, Jonathan, Lane, William J., Salazar, Andres M., Daley, Heather, Wen, Patrick Y., Chiocca, E. Antonio, Harden, Maegan, Lennon, Niall J., Gabriel, Stacey, Getz, Gad, Lander, Eric S., Regev, Aviv, Ritz, Jerome, Neuberg, Donna, Rodig, Scott J., Ligon, Keith L., Suvà, Mario L., Wucherpfennig, Kai W., Hacohen, Nir, Fritsch, Edward F., Livak, Kenneth J., Ott, Patrick A., Wu, Catherine J., Reardon, David A.

“…Neoantigens, which are derived from tumour-specific protein-coding mutations, are exempt from central tolerance, can generate robust immune responses 1 , 2 and…”
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Phase I Trial of Autologous CAR T Cells Targeting NKG2D Ligands in Patients with AML/MDS and Multiple Myeloma by Baumeister, Susanne H, Murad, Joana, Werner, Lillian, Daley, Heather, Trebeden-Negre, Helene, Gicobi, Joanina K, Schmucker, Adam, Reder, Jake, Sentman, Charles L, Gilham, David E, Lehmann, Frédéric F, Galinsky, Ilene, DiPietro, Heidi, Cummings, Kristen, Munshi, Nikhil C, Stone, Richard M, Neuberg, Donna S, Soiffer, Robert, Dranoff, Glenn, Ritz, Jerome, Nikiforow, Sarah

“…NKG2D ligands are widely expressed in solid and hematologic malignancies but absent or poorly expressed on healthy tissues. We conducted a phase I…”
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Epstein‐Barr virus‐specific adoptive immunotherapy for recurrent, metastatic nasopharyngeal carcinoma by Huang, Julian, Fogg, Mark, Wirth, Lori J., Daley, Heather, Ritz, Jerome, Posner, Marshall R., Wang, Fred C., Lorch, Jochen H.

“…BACKGROUND Early‐stage and intermediate‐stage nasopharyngeal cancer (NPC) generally carry a good prognosis, but for patients with recurrent, metastatic…”
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The feasibility of using an autologous GM-CSF-secreting breast cancer vaccine to induce immunity in patients with stage II–III and metastatic breast cancers by Anderson, Karen S., Erick, Timothy K., Chen, Meixuan, Daley, Heather, Campbell, Margaret, Colson, Yolonda, Mihm, Martin, Zakka, Labib R., Hopper, Marika, Barry, William, Winer, Eric P., Dranoff, Glenn, Overmoyer, Beth

“…Purpose The antigenic targets of immunity and the role of vaccination in breast cancer are unknown. We performed a phase I study of an autologous…”
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CTLA-4 Blockade Results in the Enrichment of Proliferative CD56 dimCD16 + NK Cells Following Infusion of Haploidentical Donor Memory-like Natural Killer Cells Plus IL-15 Superagonist in a Phase 1 Trial by Shapiro, Roman M., Sheffer, Michal, Booker, Matthew Aaron, Tolstorukov, Michael Yevgeniy, Ansuinelli, Michela, Sade-Feldman, Moshe, Fang, Jacy, Birch, Grace Caroline, Vergara-Cadavid, Juliana, Abdulhamid, Yasmin Z, Kaplan, Isabel E, Khanhlinh, Dinh, Redd, Robert A., Alonso, Alejandro, Bat-Erdene, Denbaa, Uppaluri, Ravindra, Daley, Heather, Hernandez Rodriguez, Diego, Koreth, John, Ritz, Jerome, Nikiforow, Sarah, Soiffer, Robert J., Hanna, Glenn J, Romee, Rizwan

“…Introduction Regulatory T cells (Tregs) blunt anti-tumor responses of major immune effector cells including CD8 T cells and natural killer (NK) cells. Tregs…”
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Expansion, Persistence, and Characteristics of Autologous, Bhv-1100 Armored Memory-like NK Cells Infused Prior to Autologous Stem Cell Transplant in MRD+ Multiple Myeloma Patients: A First-in-Human Trial by Birch, Grace Caroline, Vergara-Cadavid, Juliana, Maqbool, Mohsin, Martini, Alba, Dinh, Khanlinh, Shapiro, Roman M., Ansuinelli, Michela, Nguyen, Tuyet, Reynolds, Carol, Soo Y, Im, Wei, Hope, Hogan, Sarah, Kendricken, Elizabeth, Sperling, Adam S., Nadeem, Omar, Laubach, Jacob, Rybicki, Alissa, Schnittman, Steven, Stock, Elyse, Hernandez Rodriguez, Diego, Daley, Heather, Nikiforow, Sarah, Ritz, Jerome, Soiffer, Robert J., Bianchi, Giada, Romee, Rizwan

“…Introduction/Background Autologous stem cell transplant (ASCT) improves MRD negativity and prolongs progression-free survival in patients with multiple myeloma…”
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Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis by Sîrbulescu, Ruxandra F., Nicholson, Katharine, Kawai, Kento, Hilton, Orla M., Sobell, Don, Jin, Gina, Verrill, David E., Dwyer, Liam J., Xiong, Yueyue, Bachanová, Petra, Kim, Spencer E., Gallup, Shannon, Gelevski, Dario, Daley, Heather, Hernandez Rodriguez, Diego E., Negre, Hélène, Sturtevant, Olive, Nikiforow, Sarah, Ritz, Jerome, Chen, Yi‐Bin, Reeves, Patrick M., Sluder, Ann E., Berry, James D., Sadri‐Vakili, Ghazaleh, Cudkowicz, Merit, Poznansky, Mark C.

“…Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease. Immune system dysregulation plays an essential role in ALS onset and progression…”
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Phase 1 study of CAR-37 T cells in patients with relapsed or refractory CD37+ lymphoid malignancies by Frigault, Matthew J., Graham, Charlotte E., Berger, Trisha R., Ritchey, Julie, Horick, Nora K., El-Jawahri, Areej, Scarfò, Irene, Schmidts, Andrea, Haradhvala, Nicholas J., Wehrli, Marc, Lee, Won-Ho, Parker, Aiyana L., Wiggin, Hadley R., Bouffard, Amanda, Dey, Aonkon, Leick, Mark B., Katsis, Katelin, Elder, Eva L., Dolaher, Maria A., Cook, Daniella T., Chekmasova, Alena A., Huang, Lu, Nikiforow, Sarah, Daley, Heather, Ritz, Jerome, Armant, Myriam, Preffer, Fred, DiPersio, John F., Nardi, Valentina, Chen, Yi-Bin, Gallagher, Kathleen M. E., Maus, Marcela V.

“…•CAR-37 T cells expanded to >98% of T cells and led to complete responses but caused severe cytopenia associated with high levels of IL-18.•Depleting CAR-37 T…”
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Cytokine-Induced Memory-like NK Cells Exhibit Massive Expansion and Long-Term Persistence after Infusion Post-Haploidentical Stem Cell Transplantation: A Report of the First Three Cases in a Phase I Trial by Shapiro, Roman M, Nikiforow, Sarah, Rambaldi, Benedetta, Vergara, Juliana, Daley, Heather, Kim, Haesook T., Cutler, Corey, Ho, Vincent T., Koreth, John, Gooptu, Mahasweta, Antin, Joseph H., Brock, Jennifer, Wu, Catherine J., Soiffer, Robert J., Ritz, Jerome, Romee, Rizwan

“…Background Relapse of acute myeloid leukemia (AML) after allogeneic stem cell transplant has a poor prognosis with limited treatment options. Cytokine-induced…”
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