Search Results - "Daley, George Q."

The Toughest Triage — Allocating Ventilators in a Pandemic by Truog, Robert D, Mitchell, Christine, Daley, George Q

“…Of all the medical care that will have to be rationed during the Covid-19 pandemic, the most problematic will be mechanical ventilation. One strategy for…”
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Lin28: Primal Regulator of Growth and Metabolism in Stem Cells by Shyh-Chang, Ng, Daley, George Q.

“…In recent years, the highly conserved Lin28 RNA-binding proteins have emerged as factors that define stemness in several tissue lineages. Lin28 proteins…”
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The Promise and Perils of Stem Cell Therapeutics by DALEY, George Q

“…Stem cells are the seeds of tissue repair and regeneration and a promising source for novel therapies. However, apart from hematopoietic stem cell (HSC)…”
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The promise of induced pluripotent stem cells in research and therapy by Robinton, Daisy A., Daley, George Q.

“…The field of stem-cell biology has been catapulted forward by the startling development of reprogramming technology. The ability to restore pluripotency to…”
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Origins and implications of pluripotent stem cell variability and heterogeneity by Cahan, Patrick, Daley, George Q.

“…Key Points There are marked differences in the in vitro differentiation capacity of pluripotent stem cell lines, including embryonic stem (ES) cells and…”
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Stem cell metabolism in tissue development and aging by Shyh-Chang, Ng, Daley, George Q, Cantley, Lewis C

“…Recent advances in metabolomics and computational analysis have deepened our appreciation for the role of specific metabolic pathways in dictating cell fate…”
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Stem cells and the evolving notion of cellular identity by Daley, George Q.

“…Stem cells are but one class of the myriad types of cells within an organism. With potential to self-renew and capacity to differentiate, stem cells play…”
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Polar Extremes in the Clinical Use of Stem Cells by Daley, George Q

“…The U.S. biotechnology and pharmaceutical industries arguably lead the world in innovation while operating under stringent regulations set by the Food and Drug…”
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Reprogramming Cellular Identity for Regenerative Medicine by Cherry, Anne B.C., Daley, George Q.

“…Although development leads unidirectionally toward more restricted cell fates, recent work in cellular reprogramming has proven that one cellular identity can…”
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Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal by Zhang, Jin, Nuebel, Esther, Daley, George Q., Koehler, Carla M., Teitell, Michael A.

“…Small, rapidly dividing pluripotent stem cells (PSCs) have unique energetic and biosynthetic demands compared with typically larger, quiescent differentiated…”
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Metabolic Switches Linked to Pluripotency and Embryonic Stem Cell Differentiation by Shyh-Chang, Ng, Daley, George Q.

“…Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find…”
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The Lin28/let-7 Axis Regulates Glucose Metabolism by Zhu, Hao, Shyh-Chang, Ng, Segrè, Ayellet V., Shinoda, Gen, Shah, Samar P., Einhorn, William S., Takeuchi, Ayumu, Engreitz, Jesse M., Hagan, John P., Kharas, Michael G., Urbach, Achia, Thornton, James E., Triboulet, Robinson, Gregory, Richard I., Altshuler, David, Daley, George Q.

“…The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/ b promote malignancy by inhibiting…”
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Selective Blockade of MicroRNA Processing by Lin28 by Viswanathan, Srinivas R, Daley, George Q, Gregory, Richard I

“…MicroRNAs (miRNAs) play critical roles in development, and dysregulation of miRNA expression has been observed in human malignancies. Recent evidence suggests…”
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De novo generation of HSCs from somatic and pluripotent stem cell sources by Vo, Linda T., Daley, George Q.

“…Generating human hematopoietic stem cells (HSCs) from autologous tissues, when coupled with genome editing technologies, is a promising approach for cellular…”
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CellNet: Network Biology Applied to Stem Cell Engineering by Cahan, Patrick, Li, Hu, Morris, Samantha A., Lummertz da Rocha, Edroaldo, Daley, George Q., Collins, James J.

“…Somatic cell reprogramming, directed differentiation of pluripotent stem cells, and direct conversions between differentiated cell lineages represent…”
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Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors by Doulatov, Sergei, Vo, Linda T., Chou, Stephanie S., Kim, Peter G., Arora, Natasha, Li, Hu, Hadland, Brandon K., Bernstein, Irwin D., Collins, James J., Zon, Leonard I., Daley, George Q.

“…Human pluripotent stem cells (hPSCs) represent a promising source of patient-specific cells for disease modeling, drug screens, and cellular therapies…”
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A blueprint for engineering cell fate： current technologies to reprogram cell identity by Morris, Samantha A, Daley, George Q

“…Human diseases such as heart failure, diabetes, neurodegenerative disorders, and many others result from the deficiency or dysfunction of critical cell types…”
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Use of differentiated pluripotent stem cells as replacement therapy for treating disease by Fox, Ira J., Daley, George Q., Goldman, Steven A., Huard, Johnny, Kamp, Timothy J., Trucco, Massimo

“…Challenges for stem cell–based therapies Patient-derived pluripotent stem cells (PSCs) hold promise in the treatment of injury and disease. An ever-increasing…”
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LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency by Zhang, Jin, Ratanasirintrawoot, Sutheera, Chandrasekaran, Sriram, Wu, Zhaoting, Ficarro, Scott B., Yu, Chunxiao, Ross, Christian A., Cacchiarelli, Davide, Xia, Qing, Seligson, Marc, Shinoda, Gen, Xie, Wen, Cahan, Patrick, Wang, Longfei, Ng, Shyh-Chang, Tintara, Supisara, Trapnell, Cole, Onder, Tamer, Loh, Yuin-Han, Mikkelsen, Tarjei, Sliz, Piotr, Teitell, Michael A., Asara, John M., Marto, Jarrod A., Li, Hu, Collins, James J., Daley, George Q.

“…The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency, but their exact functions are poorly…”
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Confronting stem cell hype by Caulfield, Timothy, Sipp, Douglas, Murry, Charles E., Daley, George Q., Kimmelman, Jonathan

“…Against hyperbole, distortion, and overselling The way science is represented to the public can influence understanding and expectations, frame policy debates,…”
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