Search Results - "Daley, Eileen J"

β-Catenin mediates glucose-dependent insulinotropic polypeptide increases in lysyl oxidase expression in osteoblasts by Daley, Eileen J., Trackman, Philip C.

“…Osteoblast lysyl oxidase (LOX) is a strongly up-regulated mRNA and protein by the glucose-dependent insulinotropic polypeptide (GIP). LOX is critically…”
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Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus by Daley, Eileen J, Pajevic, Paola Divieti, Roy, Sayon, Trackman, Philip C

“…ABSTRACT Diabetic bone disease is a complication of type I and type II diabetes, both of which are increasing in the United States and elsewhere. Increased hip…”
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Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo by Liu, Shi, Yu, Zhen, Daley, Eileen J, Bingman, Craig A, Bruchs, Austin T, Gardella, Thomas J, Gellman, Samuel H

“…The parathyroid hormone type 1 receptor (PTHR1), a Class B GPCR, is activated by long polypeptides, including drugs for osteoporosis and hypoparathyroidism…”
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The PYY/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass by Zahedi, Bita, Daley, Eileen J., Brooks, Daniel J., Bruce, Michael, Townsend, R. Leigh, Berthoud, Hans-Rudolf, Bouxsein, Mary L., Yu, Elaine W.

“…Peptide YY (PYY) is an anorexigenic gut hormone that also has anti-osteogenic effects, inhibiting osteoblastic activity and inducing catabolic effects. It has…”
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O‑GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity by Levine, Paul M, Balana, Aaron T, Sturchler, Emmanuel, Koole, Cassandra, Noda, Hiroshi, Zarzycka, Barbara, Daley, Eileen J, Truong, Tin T, Katritch, Vsevolod, Gardella, Thomas J, Wootten, Denise, Sexton, Patrick M, McDonald, Patricia, Pratt, Matthew R

“…Peptide agonists of GPCRs and other receptors are powerful signaling molecules with high potential as biological tools and therapeutics, but they are typically…”
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Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants by Liu, Shi, Daley, Eileen J., Tran, Lauren My-Linh, Yu, Zhen, Reyes, Monica, Dean, Thomas, Khatri, Ashok, Levine, Paul M., Balana, Aaron T., Pratt, Matthew R., Jüppner, Harald, Gellman, Samuel H., Gardella, Thomas J.

“…Parathyroid hormone 1 receptor (PTH1R) plays a key role in mediating calcium homeostasis and bone development, and aberrant PTH1R activity underlies several…”
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Ligand-Dependent Effects of Methionine-8 Oxidation in Parathyroid Hormone Peptide Analogues by Daley, Eileen J, Khatri, Ashok, Dean, Thomas, Vilardaga, Jean-Pierre, Zaidi, Saheem A, Katritch, Vsevolod, Gardella, Thomas J

“…LA-PTH is a long-acting parathyroid hormone (PTH) peptide analogue in preclinical development for hypoparathyroidism (HP). Like native PTH, LA-PTH contains a…”
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Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice by Daley, Eileen J, Yoon, Sung-Hee, Reyes, Monica, Bruce, Michael, Brooks, Daniel J, Bouxsein, Mary, Potts, John T, Kronenberg, Henry M, Wein, Marc N, Lanske, Beate, Jüppner, Harald, Gardella, Thomas J

“…Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related protein (PTHrP) ligands and analogues for their pharmacologic activities…”
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