Search Results - "Dales, N."

Surfactant effects on protein structure examined by electrospray ionization mass spectrometry by Loo, R. R. Ogorzalek, Dales, N., Andrews, P. C.

“…Electrospray ionization mass spectrometry (ESI‐MS) has proven to be a useful tool for examining noncovalent complexes between proteins and a variety of…”
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The effect of detergents on proteins analyzed by electrospray ionization by Loo, R R, Dales, N, Andrews, P C

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Design and Synthesis of Unsymmetrical Peptidyl Urea Inhibitors of Aspartic Peptidases by Dales, Natalie A, Bohacek, Regine S, Satyshur, Kenneth A, Rich, Daniel H

“…The design, synthesis, and enzyme inhibition of a new class of aspartic peptidase inhibitors is described. Unsymmetrical ureas were designed from…”
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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron‑2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA) by Cheung, Atwood K, Hurley, Brian, Kerrigan, Ryan, Shu, Lei, Chin, Donovan N, Shen, Yiping, O’Brien, Gary, Sung, Moo Je, Hou, Ying, Axford, Jake, Cody, Emma, Sun, Robert, Fazal, Aleem, Tomlinson, Ronald C, Jain, Monish, Deng, Lin, Hoffmaster, Keith, Song, Cheng, Van Hoosear, Mailin, Shin, Youngah, Servais, Rebecca, Towler, Christopher, Hild, Marc, Curtis, Daniel, Dietrich, William F, Hamann, Lawrence G, Briner, Karin, Chen, Karen S, Kobayashi, Dione, Sivasankaran, Rajeev, Dales, Natalie A

“…Spinal muscular atrophy (SMA), a rare neuromuscular disorder, is the leading genetic cause of death in infants and toddlers. SMA is caused by the deletion or a…”
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ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis by Towler, Paul, Staker, Bart, Prasad, Sridhar G., Menon, Saurabh, Tang, Jin, Parsons, Thomas, Ryan, Dominic, Fisher, Martin, Williams, David, Dales, Natalie A., Patane, Michael A., Pantoliano, Michael W.

“…The angiotensin-converting enzyme (ACE)-related carboxypeptidase, ACE2, is a type I integral membrane protein of 805 amino acids that contains one HEXXH + E…”
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Synthesis of large multideterminant peptide immunogens using a poly-proline beta-turn helix motif by Fontenot, J D, Finn, O J, Dales, N, Andrews, P C, Montelaro, R C

“…We report the synthesis and characterization of a novel secondary structural motif, the poly-proline beta-turn helix. This motif is found in the proline-rich…”
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Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors by Dales, Natalie A, Gould, Alexandra E, Brown, James A, Calderwood, Emily F, Guan, Bing, Minor, Charles A, Gavin, James M, Hales, Paul, Kaushik, Virendar K, Stewart, Michael, Tummino, Peter J, Vickers, Chad S, Ocain, Timothy D, Patane, Michael A

“…Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified…”
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Enzymatic Characterization of the Pancreatic Islet-specific Glucose-6-Phosphatase-related Protein (IGRP) by Petrolonis, Anthony J, Yang, Qing, Tummino, Peter J, Fish, Susan M, Prack, Andrea E, Jain, Sadhana, Parsons, Thomas F, Li, Ping, Dales, Natalie A, Ge, Lin, Langston, Steven P, Schuller, Alwin G P, An, W Frank, Tartaglia, Louis A, Chen, Hong, Hong, Suk-Bong

“…Glucose is the main physiological stimulus for insulin biosynthesis and secretion by pancreatic β-cells. Glucose-6-phosphatase (G-6-Pase) catalyzes the…”
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Synthesis of (3R)-Amino-(2S)-Hydroxy Amino Acids for Inhibition of Methionine Aminopeptidase-1 by Keding, Stacy J., Dales, Natalie A., Lim, Sejin, Beaulieu, Danielle, Rich, Daniel H.

“…(3R)-amino-(2S)-hydroxy heptanoic acid (AHHpA) was synthesized via asymmetric aminohydroxylation and coupled with di-and tripeptides to form three compounds…”
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Transformation of Peptides into Non-Peptides. Synthesis of Computer-Generated Enzyme Inhibitors by Daniel H. Richu, Regine S. Bohacek, Natalie A. Dales, Peter Glunz, Amy S. Ripka

“…With the intent of discovering novel molecular scaffolds for designing protease inhibitors, the computer program GrowMol was used to generate peptidemimetic…”
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