Search Results - "Dalecki, Alex G"

Differential Susceptibility of Mycoplasma and Ureaplasma Species to Compound-Enhanced Copper Toxicity by Totten, Arthur H, Crawford, Cameron L, Dalecki, Alex G, Xiao, Li, Wolschendorf, Frank, Atkinson, Thomas P

“…Mycoplasmas represent important etiologic agents of many human diseases. Due to increasing antimicrobial resistance and slow rate of novel discovery,…”
Get full text

Copper and Antibiotics: Discovery, Modes of Action, and Opportunities for Medicinal Applications by Dalecki, Alex G, Crawford, Cameron L, Wolschendorf, Frank

“…Copper is a ubiquitous element in the environment as well as living organisms, with its redox capabilities and complexation potential making it indispensable…”
Get more information

Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner by Dalecki, Alex G, Haeili, Mehri, Shah, Santosh, Speer, Alexander, Niederweis, Michael, Kutsch, Olaf, Wolschendorf, Frank

“…Tuberculosis is a severe disease affecting millions worldwide. Unfortunately, treatment strategies are hampered both by the prohibitively long treatment…”
Get full text

8-Hydroxyquinolines Are Boosting Agents of Copper-Related Toxicity in Mycobacterium tuberculosis by Shah, Santosh, Dalecki, Alex G, Malalasekera, Aruni P, Crawford, Cameron L, Michalek, Suzanne M, Kutsch, Olaf, Sun, Jim, Bossmann, Stefan H, Wolschendorf, Frank

“…Copper (Cu) ions are likely the most important immunological metal-related toxin utilized in controlling bacterial infections. Impairment of bacterial Cu…”
Get full text

Development of a web-based tool for automated processing and cataloging of a unique combinatorial drug screen by Dalecki, Alex G., Wolschendorf, Frank

“…Facing totally resistant bacteria, traditional drug discovery efforts have proven to be of limited use in replenishing our depleted arsenal of therapeutic…”
Get full text

A copper-dependent compound restores ampicillin sensitivity in multidrug-resistant Staphylococcus aureus by Crawford, Cameron L., Dalecki, Alex G., Perez, Mildred D., Schaaf, Kaitlyn, Wolschendorf, Frank, Kutsch, Olaf

“…Multi-drug resistant Staphylococcus aureus , including methicillin-resistant S. aureus (MRSA), has become a worldwide, major health care problem. While…”
Get full text

High-throughput screening and Bayesian machine learning for copper-dependent inhibitors of Staphylococcus aureus by Dalecki, Alex G, Zorn, Kimberley M, Clark, Alex M, Ekins, Sean, Narmore, Whitney T, Tower, Nichole, Rasmussen, Lynn, Bostwick, Robert, Kutsch, Olaf, Wolschendorf, Frank

“…One potential source of new antibacterials is through probing existing chemical libraries for copper-dependent inhibitors (CDIs), i.e., molecules with…”
Get full text

Targeting Biofilm Associated Staphylococcus aureus Using Resazurin Based Drug-susceptibility Assay by Dalecki, Alex G, Crawford, Cameron L, Wolschendorf, Frank

“…Most pathogenic bacteria are able to form biofilms during infection, but due to the difficulty of manipulating and assessing biofilms, the vast majority of…”
Get full text

Repurposing sunscreen as an antibiotic: zinc-activated avobenzone inhibits methicillin-resistant Staphylococcus aureus by Andrews, Rachel M, Bollar, Gretchen E, Giattina, A Sophia, Dalecki, Alex G, Wallace Jr, John R, Frantz, Leah, Eschliman, Kayla, Covarrubias-Zambrano, Obdulia, Keith, Johnathan D, Duverger, Alexandra, Wagner, Frederic, Wolschendorf, Frank, Bossmann, Stefan H, Birket, Susan E, Kutsch, Olaf

“…Abstract Methicillin-resistant Staphylococcus aureus (MRSA) is a major healthcare concern with associated healthcare costs reaching over ${\$}$1 billion in a…”
Get full text

Combinatorial phenotypic screen uncovers unrecognized family of extended thiourea inhibitors with copper-dependent anti-staphylococcal activity by Dalecki, Alex G, Malalasekera, Aruni P, Schaaf, Kaitlyn, Kutsch, Olaf, Bossmann, Stefan H, Wolschendorf, Frank

“…The continuous rise of multi-drug resistant pathogenic bacteria has become a significant challenge for the health care system. In particular, novel drugs to…”
Get full text

Commercially available complement component-depleted sera are unexpectedly codepleted of ficolin-2 by Brady, Allison M, Geno, K Aaron, Dalecki, Alex G, Cheng, Xiaogang, Nahm, Moon H

“…The ficolins are a family of innate pattern recognition molecules that are known to bind acetylated compounds and activate complement through the association…”
Get full text

Pyrazolopyrimidinones, a novel class of copper-dependent bactericidal antibiotics against multi-drug resistant S. aureus by Crawford, Cameron L, Dalecki, Alex G, Narmore, Whitney T, Hoff, Jessica, Hargett, Audra A, Renfrow, Matthew B, Zhang, Man, Kalubowilage, Madumali, Bossmann, Stefan H, Queern, Stacy L, Lapi, Suzanne E, Hunter, Robert N, Bao, Donghui, Augelli-Szafran, Corinne E, Kutsch, Olaf, Wolschendorf, Frank

“…The treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections poses a therapeutic challenge as even last resort drugs become increasingly…”
Get full text

Targeting Biofilm Associated Staphylococcus aureus Using Resazurin Based Drug-susceptibility Assay by Dalecki, Alex G., Crawford, Cameron L., Wolschendorf, Frank

Get full text

High-throughput screening and Bayesian machine learning for copper-dependent inhibitors of Staphylococcus aureusElectronic supplementary information (ESI) available: Screening data is available on PubChem Bioassay. The Assay Central model is available at https://github.com/adalecki/sr_40k/raw/master/SR_40k_Metallomics_Assay_Central.jar. See DOI: 10.1039/c8mt00342d by Dalecki, Alex G, Zorn, Kimberley M, Clark, Alex M, Ekins, Sean, Narmore, Whitney T, Tower, Nichole, Rasmussen, Lynn, Bostwick, Robert, Kutsch, Olaf, Wolschendorf, Frank

“…One potential source of new antibacterials is through probing existing chemical libraries for copper-dependent inhibitors (CDIs), i.e. , molecules with…”
Get full text

Cheminformatic Discovery and Characterization of Copper-dependent Bacterial Inhibitors by Dalecki, Alex G

“…Deaths due to antibiotic-resistant bacteria are predicted to exceed 10 million per year by 2050, endangering our ability to conduct fundamental medical…”
Get full text

Pyrazolopyrimidinones, a novel class of copper-dependent bactericidal antibiotics against multi-drug resistant S. aureusElectronic supplementary information (ESI) available. See DOI: 10.1039/c8mt00316e by Crawford, Cameron L, Dalecki, Alex G, Narmore, Whitney T, Hoff, Jessica, Hargett, Audra A, Renfrow, Matthew B, Zhang, Man, Kalubowilage, Madumali, Bossmann, Stefan H, Queern, Stacy L, Lapi, Suzanne E, Hunter, Robert N, Bao, Donghui, Augelli-Szafran, Corinne E, Kutsch, Olaf, Wolschendorf, Frank

“…The treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections poses a therapeutic challenge as even last resort drugs become increasingly…”
Get full text