Search Results - "Dale Brown, R."

Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension by Hu, Cheng-Jun, Poth, Jens M, Zhang, Hui, Flockton, Amanda, Laux, Aya, Kumar, Sushil, McKeon, Brittany, Mouradian, Gary, Li, Min, Riddle, Suzette, Pugliese, Steven C, Brown, R Dale, Wallace, Eli M, Graham, Brian B, Frid, Maria G, Stenmark, Kurt R

“…Most published studies addressing the role of hypoxia inducible factors (HIFs) in hypoxia-induced pulmonary hypertension development employ models that may not…”
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TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension by Kumar, Rahul, Mickael, Claudia, Kassa, Biruk, Gebreab, Liya, Robinson, Jeffrey C., Koyanagi, Daniel E., Sanders, Linda, Barthel, Lea, Meadows, Christina, Fox, Daniel, Irwin, David, Li, Min, McKeon, B. Alexandre, Riddle, Suzette, Dale Brown, R., Morgan, Leslie E., Evans, Christopher M., Hernandez-Saavedra, Daniel, Bandeira, Angela, Maloney, James P., Bull, Todd M., Janssen, William J., Stenmark, Kurt R., Tuder, Rubin M., Graham, Brian B.

“…Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular…”
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17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin by Frump, Andrea L, Albrecht, Marjorie, Yakubov, Bakhtiyor, Breuils-Bonnet, Sandra, Nadeau, Valérie, Tremblay, Eve, Potus, Francois, Omura, Junichi, Cook, Todd, Fisher, Amanda, Rodriguez, Brooke, Brown, R Dale, Stenmark, Kurt R, Rubinstein, C Dustin, Krentz, Kathy, Tabima, Diana M, Li, Rongbo, Sun, Xin, Chesler, Naomi C, Provencher, Steeve, Bonnet, Sebastien, Lahm, Tim

“…Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are…”
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The cardiac fibroblast: Therapeutic target in myocardial remodeling and failure by DALE BROWN, R, AMBLER, S. Kelly, MITCHELL, M. Darren, LONG, Carlin S

“…Cardiac fibroblasts play a central role in the maintenance of extracellular matrix in the normal heart and as mediators of inflammatory and fibrotic myocardial…”
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RNA-Binding Proteins in Pulmonary Hypertension by Zhang, Hui, Brown, R Dale, Stenmark, Kurt R, Hu, Cheng-Jun

“…Pulmonary hypertension (PH) is a life-threatening disease characterized by significant vascular remodeling and aberrant expression of genes involved in…”
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Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro by Petrou, Cassandra L, D'Ovidio, Tyler J, Bölükbas, Deniz A, Tas, Sinem, Brown, R Dale, Allawzi, Ayed, Lindstedt, Sandra, Nozik-Grayck, Eva, Stenmark, Kurt R, Wagner, Darcy E, Magin, Chelsea M

“…Fibrotic disorders account for over one third of mortalities worldwide. Despite great efforts to study the cellular and molecular processes underlying…”
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Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload by Kheyfets, Vitaly O, Kumar, Sushil, Heerdt, Paul M, Ichimura, Kenzo, Brown, R Dale, Lucero, Melissa, Essafri, Ilham, Williams, Sarah, Stenmark, Kurt R, Spiekerkoetter, Edda

“…This study analyzed microarray data of right ventricular (RV) tissue from rats exposed to pulmonary embolism to understand the initial dynamic transcriptional…”
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The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation by Bruns, Danielle R, Tatman, Philip D, Kalkur, Roshni S, Brown, R Dale, Stenmark, Kurt R, Buttrick, Peter M, Walker, Lori A

“…In virtually all models of heart failure, prognosis is determined by right ventricular (RV) function; thus, understanding the cellular mechanisms contributing…”
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Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension by Li, Min, Riddle, Suzette, Kumar, Sushil, Poczobutt, Joanna, McKeon, B Alexandre, Frid, Maria G, Ostaff, Maureen, Reisz, Julie A, Nemkov, Travis, Fini, Mehdi A, Laux, Aya, Hu, Cheng-Jun, El Kasmi, Karim C, D'Alessandro, Angelo, Brown, R Dale, Zhang, Hui, Stenmark, Kurt R

“…The recruitment and subsequent polarization of inflammatory monocytes/macrophages in the perivascular regions of pulmonary arteries is a key feature of…”
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Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction by Bruns, Danielle R, Brown, R Dale, Stenmark, Kurt R, Buttrick, Peter M, Walker, Lori A

“…Right ventricular (RV) function is a key determinant of survival in patients with both RV and left ventricular (LV) failure, yet the mechanisms of RV failure…”
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Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages by Kumar, Sushil, Frid, Maria G, Zhang, Hui, Li, Min, Riddle, Suzette, Brown, R Dale, Yadav, Subhash Chandra, Roy, Micaela K, Dzieciatkowska, Monika E, D'Alessandro, Angelo, Hansen, Kirk C, Stenmark, Kurt R

“…Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by complement-dependent, fibroblast-induced perivascular accumulation and…”
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Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension by Applegate, Tanya J., Krafsur, Greta M., Boon, June A., Zhang, Hui, Li, Min, Holt, Timothy N., Ambler, S. Kelly, Abrams, Benjamin A., Gustafson, Daniel L., Bartels, Karsten, Garry, Franklyn B., Stenmark, Kurt R., Brown, R. Dale

“…Pulmonary hypertension (PH) is an incurable condition in humans; driven by pulmonary vascular remodeling partially mediated by epigenetic mechanisms; and…”
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MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension by Brown, R Dale, Ambler, S Kelly, Li, Min, Sullivan, Timothy M, Henry, Lauren N, Crossno, Jr, Joseph T, Long, Carlin S, Garrington, Timothy P, Stenmark, Kurt R

“…Pulmonary hypertension (PH) results in pressure overload of the right ventricle (RV) of the heart, initiating pathological RV remodeling and ultimately leading…”
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Right Ventricular Longitudinal Strain Is Depressed in a Bovine Model of Pulmonary Hypertension by Bartels, Karsten, Brown, R. Dale, Fox, Daniel L., Bull, Todd M., Neary, Joseph M., Dorosz, Jennifer L., Fonseca, Brian M., Stenmark, Kurt R.

“…BACKGROUND:Pulmonary hypertension and resulting right ventricular (RV) dysfunction are associated with significant perioperative morbidity and mortality…”
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Cardiopulmonary remodeling in fattened beef cattle: a naturally occurring large animal model of obesity-associated pulmonary hypertension with left heart disease by Krafsur, Greta M., Neary, Joseph M., Garry, Franklyn, Holt, Timothy, Gould, Daniel H., Mason, Gary L., Thomas, Milton G., Enns, R. Mark, Tuder, Rubin M., Heaton, Michael P., Brown, R. Dale, Stenmark, Kurt R.

“…The obesity epidemic in developed societies has led to increased cardiovascular diseases including pulmonary hypertension associated with left heart disease…”
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Critical Role for Death-Receptor Mediated Apoptotic Signaling in Viral Myocarditis by Debiasi, Roberta L., MD, Robinson, Bridget A., MS, Leser, J. Smith, BS, Brown, R. Dale, PhD, Long, Carlin S., MD, Clarke, Penny, PhD

“…Abstract Background Apoptosis of cardiac myocytes plays a key role in the pathogenesis of many cardiac diseases, including viral myocarditis. The apoptotic…”
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A Mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado–Joseph disease-like transgenic mice by Colomer Gould, Veronica F, Goti, Daniel, Pearce, Donna, Gonzalez, Guillermo A, Gao, Hong, Bermudez de Leon, Mario, Jenkins, Nancy A, Copeland, Neal G, Ross, Christopher A, Brown, Dale R

“…Abstract Machado–Joseph disease also called spinocerebellar ataxia type 3 (MJD/SCA3) is a hereditary and neurodegenerative movement disorder caused by ataxin-3…”
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Caspase Inhibition Protects against Reovirus-Induced Myocardial Injury In Vitro and In Vivo by DEBIASI, Roberta L, ROBINSON, Bridget A, SHERRY, Barbara, BOUCHARD, Ron, BROWN, R. Dale, RIZEQ, Mona, LONG, Carlin, TYLER, Kenneth L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension by Hu, Cheng-Jun, Laux, Aya, Gandjeva, Aneta, Wang, Liyi, Li, Min, Brown, R Dale, Riddle, Suzette, Kheyfets, Vitaly O, Tuder, Rubin M, Zhang, Hui, Stenmark, Kurt R

“…Hypoxia-inducible factor (HIF) has received much attention as a potential pulmonary hypertension (PH) treatment target because inhibition of HIF reduces the…”
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Pulmonary Arterial Stiffness: Toward a New Paradigm in Pulmonary Arterial Hypertension Pathophysiology and Assessment by Schäfer, Michal, Myers, Cynthia, Brown, R. Dale, Frid, Maria G., Tan, Wei, Hunter, Kendall, Stenmark, Kurt R.

“…Stiffening of the pulmonary arterial bed with the subsequent increased load on the right ventricle is a paramount feature of pulmonary hypertension (PH). The…”
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