Search Results - "Dale, Glenn"

The Role of Neutrophil Elastase Inhibitors in Lung Diseases by Polverino, Eva, Rosales-Mayor, Edmundo, Dale, Glenn E., Dembowsky, Klaus, Torres, Antoni

“…In many respiratory diseases characterized by an intense inflammatory response, the balance between proteolytic enzymes (proteases, including elastases) and…”
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Murepavadin: a new antibiotic class in the pipeline by Martin-Loeches, Ignacio, Dale, Glenn E, Torres, Antoni

“…With the increase in multi-drug resistant P. aeruginosa, antimicrobials with a novel mechanism of action are needed that can target these infections. Areas…”
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Chimeric peptidomimetic antibiotics against Gram-negative bacteria by Luther, Anatol, Urfer, Matthias, Zahn, Michael, Müller, Maik, Wang, Shuang-Yan, Mondal, Milon, Vitale, Alessandra, Hartmann, Jean-Baptiste, Sharpe, Timothy, Monte, Fabio Lo, Kocherla, Harsha, Cline, Elizabeth, Pessi, Gabriella, Rath, Parthasarathi, Modaresi, Seyed Majed, Chiquet, Petra, Stiegeler, Sarah, Verbree, Carolin, Remus, Tobias, Schmitt, Michel, Kolopp, Caroline, Westwood, Marie-Anne, Desjonquères, Nicolas, Brabet, Emile, Hell, Sophie, LePoupon, Karen, Vermeulen, Annie, Jaisson, Régis, Rithié, Virginie, Upert, Grégory, Lederer, Alexander, Zbinden, Peter, Wach, Achim, Moehle, Kerstin, Zerbe, Katja, Locher, Hans H., Bernardini, Francesca, Dale, Glenn E., Eberl, Leo, Wollscheid, Bernd, Hiller, Sebastian, Robinson, John A., Obrecht, Daniel

“…There is an urgent need for new antibiotics against Gram-negative pathogens that are resistant to carbapenem and third-generation cephalosporins, against which…”
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Pharmacokinetics and Safety of Intravenous Murepavadin Infusion in Healthy Adult Subjects Administered Single and Multiple Ascending Doses by Wach, Achim, Dembowsky, Klaus, Dale, Glenn E

“…Murepavadin is the first in class of the outer membrane protein-targeting antibiotics (OMPTA) and a pathogen-specific peptidomimetic antibacterial with a…”
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Protein epitope mimetic macrocycles as biopharmaceuticals by Luther, Anatol, Moehle, Kerstin, Chevalier, Eric, Dale, Glenn, Obrecht, Daniel

“…[Display omitted] •Medium-sized macrocycles can address novel disease-relevant targets.•Protein epitope mimetics (PEM) are mimics β-hairpin and α-helical…”
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Antimicrobial Activity of Murepavadin Tested against Clinical Isolates of Pseudomonas aeruginosa from the United States, Europe, and China by Sader, Helio S, Dale, Glenn E, Rhomberg, Paul R, Flamm, Robert K

“…Murepavadin (formerly POL7080), a 14-amino-acid cyclic peptide, and comparators were tested by the broth microdilution method against 1,219 isolates from 112…”
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Rifabutin for infusion (BV100) for the treatment of severe carbapenem-resistant Acinetobacter baumannii infections by Trebosc, Vincent, Kemmer, Christian, Lociuro, Sergio, Gitzinger, Marc, Dale, Glenn E.

“…•A unexpected activity of rifabutin (RBT) towards A. baumanni has been discovered.•RBT displays a potent activity towards A. baumannii in iron depleted…”
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Pharmacokinetics, Tolerability, and Safety of Murepavadin, a Novel Antipseudomonal Antibiotic, in Subjects with Mild, Moderate, or Severe Renal Function Impairment by Dale, Glenn E, Halabi, Atef, Petersen-Sylla, Marc, Wach, Achim, Zwingelstein, Christian

“…This open-label, nonrandomized, single-dose, phase 1 study evaluated the pharmacokinetics and safety of murepavadin, a novel peptide antibiotic for the…”
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Murepavadin activity tested against contemporary (2016-17) clinical isolates of XDR Pseudomonas aeruginosa by Sader, Helio S, Flamm, Robert K, Dale, Glenn E, Rhomberg, Paul R, Castanheira, Mariana

“…Murepavadin (POL7080) represents the first member of a novel class of outer membrane protein-targeting antibiotics. Murepavadin acts by binding to LPS…”
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Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration by Antraygues, Kevin, Maingot, Mathieu, Schellhorn, Birgit, Trebosc, Vincent, Gitzinger, Marc, Deprez, Benoit, Defert, Olivier, Dale, Glenn E., Bourotte, Marilyne, Lociuro, Sergio, Willand, Nicolas

“…Acinetobacter baumannii is a gram-negative bacterium causing severe hospital-acquired infections such as bloodstream infections or pneumonia. Moreover,…”
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In vitro activity of rifabutin against 293 contemporary carbapenem-resistant Acinetobacter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms by Trebosc, Vincent, Schellhorn, Birgit, Schill, Julian, Lucchini, Valentina, Bühler, Jacqueline, Bourotte, Marilyne, Butcher, Jonathan J, Gitzinger, Marc, Lociuro, Sergio, Kemmer, Christian, Dale, Glenn E

“…Abstract Background Rifabutin, an oral drug approved to treat Mycobacterium avium infections, demonstrated potent activity against Acinetobacter baumannii in…”
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First-in-human study of alpibectir (BVL-GSK098), a novel potent anti-TB drug by Pieren, Michel, Abáigar Gutiérrez-Solana, Ana, Antonijoan Arbós, Rosa María, Boyle, Gary W, Davila, Myriam, Davy, Maria, Gitzinger, Marc, Husband, Lisa, Martínez-Martínez, María S, Mazarro, Dolores Ochoa, Pefani, Eleni, Penman, Sophie L, Remuiñán, Modesto J, Vlasakakis, Georgios, Zeitlinger, Markus, Dale, Glenn E

“…The clinical candidate alpibectir augments the activity of, and overcomes resistance to, the anti-TB drug ethionamide in vitro and in vivo. A Phase 1,…”
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Susceptibility of Pseudomonas aeruginosa Recovered from Cystic Fibrosis Patients to Murepavadin and 13 Comparator Antibiotics by Ekkelenkamp, Miquel B, Cantón, Rafael, Díez-Aguilar, María, Tunney, Michael M, Gilpin, Deirdre F, Bernardini, Francesca, Dale, Glenn E, Elborn, J Stuart, Bayjanov, Jumamurat R, Fluit, Ad

“…The objective was to determine the antimicrobial susceptibility of isolates cultured from cystic fibrosis (CF) patients and explore associations between strain…”
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Antimicrobial activity of POL7306 tested against clinical isolates of Gram-negative bacteria collected worldwide by Sader, Helio S, Rhomberg, Paul R, Duncan, Leonard R, Locher, Hans H, Dale, Glenn E, Flamm, Robert K

“…POL7306 belongs to a new class of peptidomimetic outer-membrane-protein-targeting antibiotics with a novel mechanism of action. POL7306 is in development for…”
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Efficacy of the Novel Antibiotic POL7001 in Preclinical Models of Pseudomonas aeruginosa Pneumonia by Cigana, Cristina, Bernardini, Francesca, Facchini, Marcella, Alcalá-Franco, Beatriz, Riva, Camilla, De Fino, Ida, Rossi, Alice, Ranucci, Serena, Misson, Pauline, Chevalier, Eric, Brodmann, Maj, Schmitt, Michel, Wach, Achim, Dale, Glenn E, Obrecht, Daniel, Bragonzi, Alessandra

“…The clinical development of antibiotics with a new mode of action combined with efficient pulmonary drug delivery is a priority against untreatable Pseudomonas…”
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Structure of human Endothelin-converting Enzyme I Complexed with Phosphoramidon by Schulz, Henk, Dale, Glenn E., Karimi-Nejad, Yasmin, Oefner, Christian

“…Endothelin-converting enzyme I (ECE-1) is a mammalian type II integral membrane zinc-containing endopeptidase. ECE-1 catalyzes the final step in the…”
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A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii by Luna, Brian, Trebosc, Vincent, Lee, Bosul, Bakowski, Malina, Ulhaq, Amber, Yan, Jun, Lu, Peggy, Cheng, Jiaqi, Nielsen, Travis, Lim, Juhyeon, Ketphan, Warisa, Eoh, Hyungjin, McNamara, Case, Skandalis, Nicholas, She, Rosemary, Kemmer, Christian, Lociuro, Sergio, Dale, Glenn E., Spellberg, Brad

“…Industry screens of large chemical libraries have traditionally relied on rich media to ensure rapid bacterial growth in high-throughput testing. We used…”
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Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography by Oefner, Christian, Schulz, Henk, D'Arcy, Allan, Dale, Glenn E.

“…Malonyl‐CoA–acyl carrier protein transacylase (FabD; EC 2.3.1.39) is a key enzyme in the fatty‐acid biosynthesis pathway of bacteria, catalyzing the transfer…”
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The protein as a variable in protein crystallization by Dale, Glenn E, Oefner, Christian, D’Arcy, Allan

“…Strategies for growing protein crystals have for many years been essentially empirical, the protein, once purified to a certain homogeneity, being mixed with a…”
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Author Correction: Chimeric peptidomimetic antibiotics against Gram-negative bacteria by Luther, Anatol, Urfer, Matthias, Zahn, Michael, Müller, Maik, Wang, Shuang-Yan, Mondal, Milon, Vitale, Alessandra, Hartmann, Jean-Baptiste, Sharpe, Timothy, Monte, Fabio Lo, Kocherla, Harsha, Cline, Elizabeth, Pessi, Gabriella, Rath, Parthasarathi, Modaresi, Seyed Majed, Chiquet, Petra, Stiegeler, Sarah, Verbree, Carolin, Remus, Tobias, Schmitt, Michel, Kolopp, Caroline, Westwood, Marie-Anne, Desjonquères, Nicolas, Brabet, Emile, Hell, Sophie, LePoupon, Karen, Vermeulen, Annie, Jaisson, Régis, Rithié, Virginie, Upert, Grégory, Lederer, Alexander, Zbinden, Peter, Wach, Achim, Moehle, Kerstin, Zerbe, Katja, Locher, Hans H., Bernardini, Francesca, Dale, Glenn E., Eberl, Leo, Wollscheid, Bernd, Hiller, Sebastian, Robinson, John A., Obrecht, Daniel

“…An Amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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