Search Results - "Dalby, Kevin N"

JNK Signaling in Stem Cell Self-Renewal and Differentiation by Semba, Takashi, Sammons, Rachel, Wang, Xiaoping, Xie, Xuemei, Dalby, Kevin N, Ueno, Naoto T

“…C-JUN N-terminal kinases (JNKs), which belong to the mitogen-activated protein kinase (MAPK) family, are evolutionarily conserved kinases that mediate cell…”
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ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin by Piserchio, Andrea, Long, Kimberly J, Browning, Luke S, Bohanon, Amanda L, Isiorho, Eta A, Dalby, Kevin N, Ghose, Ranajeet

“…Protein translation, one of the most energy-consumptive processes in a eukaryotic cell, requires robust regulation, especially under energy-deprived…”
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Virtual screening using molecular simulations by Yang, Tianyi, Wu, Johnny C., Yan, Chunli, Wang, Yuanfeng, Luo, Ray, Gonzales, Michael B., Dalby, Kevin N., Ren, Pengyu

“…Effective virtual screening relies on our ability to make accurate prediction of protein‐ligand binding, which remains a great challenge. In this work,…”
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Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates by Scheele, Remkes A., Lindenburg, Laurens H., Petek, Maya, Schober, Markus, Dalby, Kevin N., Hollfelder, Florian

“…The combination of ultrahigh-throughput screening and sequencing informs on function and intragenic epistasis within combinatorial protein mutant libraries…”
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MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model by Bartholomeusz, Chandra, Xie, Xuemei, Pitner, Mary Kathryn, Kondo, Kimie, Dadbin, Ali, Lee, Jangsoon, Saso, Hitomi, Smith, Paul D, Dalby, Kevin N, Ueno, Naoto T

“…Patients with triple-negative breast cancer (TNBC) have a poor prognosis because TNBC often metastasizes, leading to death. Among patients with TNBC, those…”
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Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control by Wible, Daric J., Parikh, Zalak, Cho, Eun Jeong, Chen, Miao-Der, Jeter, Collene R., Mukhopadhyay, Somshuvra, Dalby, Kevin N., Varadarajan, Shankar, Bratton, Shawn B.

“…p38 mitogen-activated protein kinases (MAPKs) participate in autophagic signaling; and previous reports suggest that pyridinyl imidazole p38 MAPK inhibitors,…”
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Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification by Perry, Nicole A., Kaoud, Tamer S., Ortega, Oscar O., Kaya, Ali I., Marcus, David J., Pleinis, John M., Berndt, Sandra, Chen, Qiuyan, Zhan, Xuanzhi, Dalby, Kevin N., Lopez, Carlos F., Iverson, T. M., Gurevich, Vsevolod V.

“…Scaffold proteins tether and orient components of a signaling cascade to facilitate signaling. Although much is known about how scaffolds colocalize signaling…”
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Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer by Gagliardi, Maria, Pitner, Mary Kathryn, Park, Jihyun, Xie, Xuemei, Saso, Hitomi, Larson, Richard A., Sammons, Rachel M., Chen, Huiqin, Wei, Caimiao, Masuda, Hiroko, Chauhan, Gaurav, Kondo, Kimie, Tripathy, Debu, Ueno, Naoto T., Dalby, Kevin N., Debeb, Bisrat G., Bartholomeusz, Chandra

“…Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer characterized by metastasis, drug resistance and high rates of recurrence. With a…”
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Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses by Silva, Rui P, Huang, Yimin, Nguyen, Annalee W, Hsieh, Ching-Lin, Olaluwoye, Oladimeji S, Kaoud, Tamer S, Wilen, Rebecca E, Qerqez, Ahlam N, Park, Jun-Gyu, Khalil, Ahmed M, Azouz, Laura R, Le, Kevin C, Bohanon, Amanda L, DiVenere, Andrea M, Liu, Yutong, Lee, Alison G, Amengor, Dzifa A, Shoemaker, Sophie R, Costello, Shawn M, Padlan, Eduardo A, Marqusee, Susan, Martinez-Sobrido, Luis, Dalby, Kevin N, D'Arcy, Sheena, McLellan, Jason S, Maynard, Jennifer A

“…To address the ongoing SARS-CoV-2 pandemic and prepare for future coronavirus outbreaks, understanding the protective potential of epitopes conserved across…”
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Short Arrestin-3-Derived Peptides Activate JNK3 in Cells by Perry-Hauser, Nicole A., Kaoud, Tamer S., Stoy, Henriette, Zhan, Xuanzhi, Chen, Qiuyan, Dalby, Kevin N., Iverson, Tina M., Gurevich, Vsevolod V., Gurevich, Eugenia V.

“…Arrestins were first discovered as suppressors of G protein-mediated signaling by G protein-coupled receptors. It was later demonstrated that arrestins also…”
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Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding by Guo, Hou-Fu, Tsai, Chi-Lin, Terajima, Masahiko, Tan, Xiaochao, Banerjee, Priyam, Miller, Mitchell D., Liu, Xin, Yu, Jiang, Byemerwa, Jovita, Alvarado, Sarah, Kaoud, Tamer S., Dalby, Kevin N., Bota-Rabassedas, Neus, Chen, Yulong, Yamauchi, Mitsuo, Tainer, John A., Phillips, George N., Kurie, Jonathan M.

“…Collagen lysyl hydroxylases (LH1-3) are Fe 2+ - and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels…”
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Novel quinoline incorporating 1,2,4-triazole/oxime hybrids: Synthesis, molecular docking, anti-inflammatory, COX inhibition, ulceroginicity and histopathological investigations by Mohassab, Aliaa M., Hassan, Heba A., Abdelhamid, Dalia, Abdel-Aziz, Mohamed, Dalby, Kevin N., Kaoud, Tamer S.

“…Compound 7c exhibited the best binding with COX-1 active site with energy score −12.20 and least biding with COX-2 active site and emphasize the idea of being…”
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JNK3 Enzyme Binding to Arrestin-3 Differentially Affects the Recruitment of Upstream Mitogen-activated Protein (MAP) Kinase Kinases by Zhan, Xuanzhi, Kaoud, Tamer S., Kook, Seunghyi, Dalby, Kevin N., Gurevich, Vsevolod V.

“…An interaction between arrestin-3 and MKK7 has never been elucidated. Results: Arrestin-3 directly binds MKK7 and promotes JNK3α2 phosphorylation by MKK7 in…”
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Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs by Sheridan, Douglas L., Kong, Yong, Parker, Sirlester A., Dalby, Kevin N., Turk, Benjamin E.

“…Mitogen-activated protein kinases (MAPKs) mediate cellular responses to a wide variety of extracellular stimuli. MAPK signal transduction cascades are tightly…”
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Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer by Tekedereli, Ibrahim, Alpay, S Neslihan, Tavares, Clint D J, Cobanoglu, Zehra E, Kaoud, Tamer S, Sahin, Ibrahim, Sood, Anil K, Lopez-Berestein, Gabriel, Dalby, Kevin N, Ozpolat, Bulent

“…Eukaryotic elongation factor 2 kinase (eEF-2K), through its phosphorylation of elongation factor 2 (eEF2), provides a mechanism by which cells can control the…”
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Construction of human activity‐based phosphorylation networks by Newman, Robert H, Hu, Jianfei, Rho, Hee‐Sool, Xie, Zhi, Woodard, Crystal, Neiswinger, John, Cooper, Christopher, Shirley, Matthew, Clark, Hillary M, Hu, Shaohui, Hwang, Woochang, Seop Jeong, Jun, Wu, George, Lin, Jimmy, Gao, Xinxin, Ni, Qiang, Goel, Renu, Xia, Shuli, Ji, Hongkai, Dalby, Kevin N, Birnbaum, Morris J, Cole, Philip A, Knapp, Stefan, Ryazanov, Alexey G, Zack, Donald J, Blackshaw, Seth, Pawson, Tony, Gingras, Anne‐Claude, Desiderio, Stephen, Pandey, Akhilesh, Turk, Benjamin E, Zhang, Jin, Zhu, Heng, Qian, Jiang

“…The landscape of human phosphorylation networks has not been systematically explored, representing vast, unchartered territories within cellular signaling…”
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The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation by Coffa, Sergio, Breitman, Maya, Hanson, Susan M, Callaway, Kari, Kook, Seunghyi, Dalby, Kevin N, Gurevich, Vsevolod V

“…Arrestins are multifunctional signaling adaptors originally discovered as proteins that "arrest" G protein activation by G protein-coupled receptors (GPCRs)…”
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Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo by Kaoud, Tamer S., Johnson, William H., Ebelt, Nancy D., Piserchio, Andrea, Zamora-Olivares, Diana, Van Ravenstein, Sabrina X., Pridgen, Jacey R., Edupuganti, Ramakrishna, Sammons, Rachel, Cano, Micael, Warthaka, Mangalika, Harger, Matthew, Tavares, Clint D. J., Park, Jihyun, Radwan, Mohamed F., Ren, Pengyu, Anslyn, Eric V., Tsai, Kenneth Y., Ghose, Ranajeet, Dalby, Kevin N.

“…Recently, the targeting of ERK with ATP-competitive inhibitors has emerged as a potential clinical strategy to overcome acquired resistance to BRAF and MEK…”
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Differential Sensing of MAP Kinases Using SOX-Peptides by Zamora-Olivares, Diana, Kaoud, Tamer S., Jose, Jiney, Ellington, Andrew, Dalby, Kevin N., Anslyn, Eric V.

“…Five SOX peptides are used to classify the MAPK groups and isoforms thereof using chemometrics. The score plots show excellent classification and accuracy,…”
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Peptide mini-scaffold facilitates JNK3 activation in cells by Zhan, Xuanzhi, Stoy, Henriette, Kaoud, Tamer S., Perry, Nicole A., Chen, Qiuyan, Perez, Alejandro, Els-Heindl, Sylvia, Slagis, Jack V., Iverson, Tina M., Beck-Sickinger, Annette G., Gurevich, Eugenia V., Dalby, Kevin N., Gurevich, Vsevolod V.

“…Three-kinase mitogen-activated protein kinase (MAPK) signaling cascades are present in virtually all eukaryotic cells. MAPK cascades are organized by scaffold…”
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