Search Results - "Dalbeth, N."

Treat-to-target (T2T) recommendations for gout by Kiltz, U, Smolen, J, Bardin, T, Cohen Solal, A, Dalbeth, N, Doherty, M, Engel, B, Flader, C, Kay, J, Matsuoka, M, Perez-Ruiz, F, da Rocha Castelar-Pinheiro, G, Saag, K, So, A, Vazquez Mellado, J, Weisman, M, Westhoff, T H, Yamanaka, H, Braun, J

“…The treat-to-target (T2T) concept has been applied successfully in several inflammatory rheumatic diseases. Gout is a chronic disease with a high burden of…”
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Mechanisms of bone erosion in gout: a quantitative analysis using plain radiography and computed tomography by Dalbeth, N, Clark, B, Gregory, K, Gamble, G, Sheehan, T, Doyle, A, McQueen, F M

“…The underlying basis of bone erosion in gout remains speculative. The aim of this study was to understand the mechanisms of bone erosion in gout using…”
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Twenty-eight loci that influence serum urate levels: analysis of association with gout by Phipps-Green, A J, Merriman, M E, Topless, R, Altaf, S, Montgomery, G W, Franklin, C, Jones, G T, van Rij, A M, White, D, Stamp, L K, Dalbeth, N, Merriman, T R

“…Twenty-eight genetic loci are associated with serum urate levels in Europeans. Evidence for association with gout at most loci is absent, equivocal or not…”
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Crystal identification of synovial fluid aspiration by polarized light microscopy. An online test suggesting that our traditional rheumatologic competence needs renewed attention and training by Berendsen, D., Neogi, T., Taylor, W. J., Dalbeth, N., Jansen, T. L.

“…Testing a reading exercise for identification of several typical crystal such as the negatively birefringent needle-shaped crystals that are under polarized…”
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Urate-induced epigenetic modifications in myeloid cells by Badii, M, Gaal, O I, Cleophas, M C, Klück, V, Davar, R, Habibi, E, Keating, S T, Novakovic, B, Helsen, M M, Dalbeth, N, Stamp, L K, Macartney-Coxson, D, Phipps-Green, A J, Stunnenberg, H G, Dinarello, C A, Merriman, T R, Netea, M G, Crişan, T O, Joosten, L A B

“…Hyperuricemia is a metabolic condition central to gout pathogenesis. Urate exposure primes human monocytes towards a higher capacity to produce and release…”
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ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout by Roberts, R L, Wallace, M C, Phipps-Green, A J, Topless, R, Drake, J M, Tan, P, Dalbeth, N, Merriman, T R, Stamp, L K

“…Many patients fail to achieve the recommended serum urate (SU) target (<6 mgdl −1 ) with allopurinol. The aim of our study was to examine the association of…”
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Mechanisms of inflammation in gout by Dalbeth, N., Haskard, D. O.

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ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches by Cleophas, M C, Joosten, L A, Stamp, L K, Dalbeth, N, Woodward, O M, Merriman, Tony R

“…As a result of the association of a common polymorphism ( , Q141K) in the ATP-binding cassette G2 (ABCG2) transporter with serum urate concentration in a…”
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IL-1β induces changes in expression of core circadian clock components PER2 and BMAL1 in primary human chondrocytes through the NMDA receptor/CREB and NF-κB signalling pathways by Alhilali, M., Hearn, J.I., Rong, J., Jain, L., Bolam, S.M., Monk, A.P., Munro, J.T., Dalbeth, N., Poulsen, R.C.

“…The circadian clock is a specialised cell signalling circuit present in almost all cells. It controls the timing of key cell activities such as proliferation…”
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Altered N-methyl D-aspartate receptor subunit expression causes changes to the circadian clock and cell phenotype in osteoarthritic chondrocytes by Kalev-Zylinska, M.L., Hearn, J.I., Rong, J., Zhu, M., Munro, J., Cornish, J., Dalbeth, N., Poulsen, R.C.

“…The chondrocyte circadian clock is altered in osteoarthritis. This change is implicated in the disease-associated changes in chondrocyte phenotype and…”
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Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout by Dalbeth, N., Merriman, T.

“…Recent studies in diverse disciplines have led to significant advances in the understanding of the basic biology of hyperuricaemia and gout, with important…”
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The risk of clinically diagnosed gout by serum urate levels: results from 30 years follow-up of the Malmö Preventive Project cohort in southern Sweden by Kapetanovic, Meliha C, Nilsson, Peter, Turesson, Carl, Englund, Martin, Dalbeth, Nicola, Jacobsson, Lennart

“…Hyperuricemia (HU) is in the causal pathway for developing clinical gout. There are few population-based assessments of the absolute and relative risk of…”
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The safety and efficacy of benzbromarone in gout in Aotearoa New Zealand by Stamp, L. K., Haslett, J., Frampton, C., White, D., Gardner, D., Stebbings, S., Taylor, G., Grainger, R., Kumar, R., Kumar, S., Kain, T., Porter, D., Corkill, M., Cathro, A., Metcalfe, S., Wyeth, J., Dalbeth, N.

“…Background Benzbromarone is a potent uricosuric but is not widely available due to concerns about hepatotoxicity. In Aotearoa New Zealand, benzbromarone has…”
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Cellular characterisation of magnetic resonance imaging bone oedema in rheumatoid arthritis; implications for pathogenesis of erosive disease by Dalbeth, N, Smith, T, Gray, S, Doyle, A, Antill, P, Lobo, M, Robinson, E, King, A, Cornish, J, Shalley, G, Gao, A, McQueen, F M

“…Magnetic resonance imaging (MRI) bone oedema is an important predictor of bone erosion in rheumatoid arthritis (RA). This study aimed to determine the cellular…”
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Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout by Vazirpanah, N, Kienhorst, L B E, Van Lochem, E, Wichers, C, Rossato, M, Shiels, P G, Dalbeth, N, Stamp, L K, Merriman, T R, Janssen, M, Radstake, T R D J, Broen, J Ca

“…Chronic inflammation associates with increased senescence, which is a strong predictor for cardiovascular disease. We hypothesised that inflammation…”
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Exploring cartilage damage in gout using 3-T MRI: distribution and associations with joint inflammation and tophus deposition by Popovich, I., Dalbeth, N., Doyle, A., Reeves, Q., McQueen, F. M.

“…Objective Few imaging studies have investigated cartilage in gout. Magnetic resonance imaging (MRI) can image cartilage damage and also reveals other features…”
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High-grade MRI bone oedema is common within the surgical field in rheumatoid arthritis patients undergoing joint replacement and is associated with osteitis in subchondral bone by McQueen, F M, Gao, A, Østergaard, M, King, A, Shalley, G, Robinson, E, Doyle, A, Clark, B, Dalbeth, N

“…Objectives:MRI bone oedema has been observed in early and advanced RA and may represent a cellular infiltrate (osteitis) in subchondral bone. We studied MRI…”
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Tophaceous joint disease strongly predicts hand function in patients with gout by Dalbeth, N., Collis, J., Gregory, K., Clark, B., Robinson, E., McQueen, F. M.

“…Objectives. The functional impact of gout is poorly understood. The aim of this study was to determine predictors of hand function in gout. Methods. Twenty…”
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Acute effect of milk on serum urate concentrations: a randomised controlled crossover trial by Dalbeth, Nicola, Wong, Sumwai, Gamble, Greg D, Horne, Anne, Mason, Barbara, Pool, Bregina, Fairbanks, Lynette, McQueen, Fiona M, Cornish, Jillian, Reid, Ian R, Palmano, Kate

“…Recent observational studies have highlighted the beneficial role of dairy ingestion in gout prevention. The aims of this study were to determine the acute…”
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Effects of knee joint aspiration and corticosteroid injection on flexion reflex excitability, pain and peak muscle torque in individuals with chronic arthritis by McNair, P.J, Rice, D, Lewis, G, Dalbeth, N

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