Search Results - "Dalbøge, Louise S."

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents by Dalbøge, Louise S, Pedersen, Philip J, Hansen, Gitte, Fabricius, Katrine, Hansen, Henrik B, Jelsing, Jacob, Vrang, Niels

“…Unlike rats and mice, hamsters develop hypercholesterolemia, and hypertriglyceridemia when fed a cholesterol-rich diet. Because hyperlipidemia is a hallmark of…”
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Characterisation of age-dependent beta cell dynamics in the male db/db mice by Dalbøge, Louise S, Almholt, Dorthe L C, Neerup, Trine S R, Vassiliadis, Efstathios, Vrang, Niels, Pedersen, Lars, Fosgerau, Keld, Jelsing, Jacob

“…To characterise changes in pancreatic beta cell mass during the development of diabetes in untreated male C57BLKS/J db/db mice. Blood samples were collected…”
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Evaluation of VGF peptides as potential anti-obesity candidates in pre-clinical animal models by Dalbøge, Louise S., Jacobsen, Julie M., Mehrotra, Suneet, Mercer, Aaron J., Cox, Nick, Liu, Fa, Bennett, Camdin M., Said, Meerit, Tang-Christensen, Mads, Raun, Kirsten, Hansen, Jakob L., Grove, Kevin L., Baquero, Arian F.

“…•VGF-derived peptides were synthesized and screened for effects on energy homeostasis.•NERP-1, PGH-NH2, HHPD-41, and TLQP-62 increased activity of hypothalamic…”
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GUB06‐046, a novel secretin/glucagon‐like peptide 1 co‐agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice by Witteloostuijn, Søren B., Dalbøge, Louise S., Hansen, Gitte, Midtgaard, Søren Roi, Jensen, Grethe Vestergaard, Jensen, Knud J., Vrang, Niels, Jelsing, Jacob, Pedersen, Søren L.

“…Bariatric surgery is currently the most effective treatment of obesity, which has spurred an interest in developing pharmaceutical mimetics. It is thought that…”
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RhoA in tyrosine hydroxylase neurones regulates food intake and body weight via altered sensitivity to peripheral hormones by Skov, Louise J., Ratner, Cecilia, Hansen, Nikolaj W., Thompson, Jonathan J., Egerod, Kristoffer L., Burm, Hayley, Dalbøge, Louise S., Hedegaard, Morten A., Brakebusch, Cord, Pers, Tune H., Perrier, Jean‐François, Holst, Birgitte

“…Dopamine‐producing tyrosine hydroxylase (TH) neurones in the hypothalamic arcuate nucleus (ARC) have recently been shown to be involved in ghrelin signalling…”
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Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats by Hansen, Carl Frederik, Bueter, Marco, Theis, Nadine, Lutz, Thomas, Paulsen, Sarah, Dalbøge, Louise S, Vrang, Niels, Jelsing, Jacob

“…Roux-en-Y gastric bypass (RYGB) leads to a rapid remission of type 2 diabetes mellitus (T2DM), but the underlying mode of action remains incompletely…”
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Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons by Roberts, Brandon L., Bennett, Baylin J., Bennett, Camdin M., Carroll, Julie M., Dalbøge, Louise S., Hall, Colin, Hassouneh, Wafa, Heppner, Kristy M., Kirigiti, Melissa A., Lindsley, Sarah R., Tennant, Katherine G., True, Cadence A., Whittle, Andrew, Wolf, Anitra C., Roberts, Charles T., Tang-Christensen, Mads, Sleeman, Mark W., Cowley, Michael A., Grove, Kevin L., Kievit, Paul

“…Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to…”
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The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss by Secher, Anna, Jelsing, Jacob, Baquero, Arian F, Hecksher-Sørensen, Jacob, Cowley, Michael A, Dalbøge, Louise S, Hansen, Gitte, Grove, Kevin L, Pyke, Charles, Raun, Kirsten, Schäffer, Lauge, Tang-Christensen, Mads, Verma, Saurabh, Witgen, Brent M, Vrang, Niels, Bjerre Knudsen, Lotte

“…Liraglutide is a glucagon-like peptide-1 (GLP-1) analog marketed for the treatment of type 2 diabetes. Besides lowering blood glucose, liraglutide also reduces…”
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Enteroendocrine K and L cells in healthy and type 2 diabetic individuals by Jorsal, Tina, Rhee, Nicolai A., Pedersen, Jens, Wahlgren, Camilla D., Mortensen, Brynjulf, Jepsen, Sara L., Jelsing, Jacob, Dalbøge, Louise S., Vilmann, Peter, Hassan, Hazem, Hendel, Jakob W., Poulsen, Steen S., Holst, Jens J., Vilsbøll, Tina, Knop, Filip K.

“…Aims/hypothesis Enteroendocrine K and L cells are pivotal in regulating appetite and glucose homeostasis. Knowledge of their distribution in humans is sparse…”
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Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery by Ratner, Cecilia, Skov, Louise J, Raida, Zindy, Bächler, Thomas, Bellmann-Sickert, Kathrin, Le Foll, Christelle, Sivertsen, Bjørn, Dalbøge, Louise S, Hartmann, Bolette, Beck-Sickinger, Annette G, Madsen, Andreas N, Jelsing, Jacob, Holst, Jens J, Lutz, Thomas A, Andrews, Zane B, Holst, Birgitte

“…Neurotensin (NT) is a peptide expressed in the brain and in the gastrointestinal tract. Brain NT inhibits food intake, but the effects of peripheral NT are…”
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Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes by Rhee, Nicolai A., Wahlgren, Camilla D., Pedersen, Jens, Mortensen, Brynjulf, Langholz, Ebbe, Wandall, Erik P., Friis, Steffen U., Vilmann, Peter, Paulsen, Sarah J., Kristiansen, Viggo B., Jelsing, Jacob, Dalbøge, Louise S., Poulsen, Steen S., Holst, Jens J., Vilsbøll, Tina, Knop, Filip K.

“…Aims/hypothesis We studied the impact of Roux-en-Y gastric bypass (RYGB) on the density and hormonal gene expression of small-intestinal enteroendocrine cells…”
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Whole transcriptome analysis and validation of metabolic pathways in subcutaneous adipose tissues during FGF21-induced weight loss in non-human primates by Murray, Sara A., Dalbøge, Louise S., Baquero, Karalee, Sanford, Christina A., Misquith, Ayesha, Mercer, Aaron J., Meek, Thomas H., Guldbrandt, Mette, Andersen, Birgitte, Kievit, Paul, Grove, Kevin L., Kutlu, Burak

“…Fibroblast growth factor 21 (FGF21) induces weight loss in mouse, monkey, and human studies. In mice, FGF21 is thought to cause weight loss by stimulating…”
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The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice by Dalbøge, Louise S, Almholt, Dorthe L C, Neerup, Trine S R, Vrang, Niels, Jelsing, Jacob, Fosgerau, Keld

“…Antidiabetic treatments aiming to preserve or even to increase β-cell mass are currently gaining increased interest. Here we investigated the effect of chronic…”
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Nephroprotective Effects of Semaglutide as Mono- and Combination Treatment with Lisinopril in a Mouse Model of Hypertension-Accelerated Diabetic Kidney Disease by Dalbøge, Louise S., Christensen, Michael, Madsen, Martin Rønn, Secher, Thomas, Endlich, Nicole, Drenic’, Vedran, Manresa-Arraut, Alba, Hansen, Henrik H., Rune, Ida, Fink, Lisbeth N., Østergaard, Mette V.

“…Background: Obesity, hyperglycemia and hypertension are critical risk factors for development of diabetic kidney disease (DKD). Emerging evidence suggests that…”
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Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake by Dalbøge, Louise S., Pedersen, Søren L., van Witteloostuijn, Søren B., Rasmussen, Jakob E., Rigbolt, Kristoffer T. G., Jensen, Knud J., Holst, Birgitte, Vrang, Niels, Jelsing, Jacob

“…Neuromedin U (NMU) is a 25 amino acid peptide expressed and secreted in the brain and gastrointestinal tract. Data have shown that peripheral administration of…”
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Neuromedin U inhibits food intake partly by inhibiting gastric emptying by Dalbøge, Louise S., Pedersen, Søren L., Secher, Thomas, Holst, Birgitte, Vrang, Niels, Jelsing, Jacob

“…•A novel lipidated NMU analog decreases food intake and gastric emptying in mice.•A novel lipidated NMU analog improves glycaemic control in mice.•NMU mRNA is…”
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Impaired Behavioural Pain Responses in hph-1 Mice with Inherited Deficiency in GTP Cyclohydrolase 1 in Models of Inflammatory Pain by Nasser, Arafat, Bjerrum, Ole J, Heegaard, Anne-Marie, Møller, Anette T, Larsen, Maj Britt, Dalbøge, Louise S, Dupont, Erik, Jensen, Troels S, Møller, Lisbeth B

“…Background GTP cyclohydrolase 1 (GTP-CH1), the rate-limiting enzyme in the synthesis of tetrahydrobiopterin (BH4), encoded by the GCH1 gene, has been…”
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Machine-Learning-Guided Peptide Drug Discovery: Development of GLP‑1 Receptor Agonists with Improved Drug Properties by Nielsen, Jens Christian, Hjo̷rringgaard, Claudia, Nygaard, Mads Mo̷rup, Wester, Anita, Elster, Lisbeth, Porsgaard, Trine, Mikkelsen, Randi Bonke, Rasmussen, Silas, Madsen, Andreas Nygaard, Schlein, Morten, Vrang, Niels, Rigbolt, Kristoffer, Dalbo̷ge, Louise S.

“…Peptide-based drug discovery has surged with the development of peptide hormone-derived analogs for the treatment of diabetes and obesity. Machine learning…”
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2584 Mapping Progression of DKD in ReninAAV UNx db/db mice utilizing time-series RNA sequencing by Marstrand-Jørgensen, Adam Bøgh, Østergaard, Mette Viberg, Kaasbøll, Ole, Dalbøge, Louise S, Christensen, Michael

“…Abstract Background and Aims The Renin adeno-associated virus (AAV) uninephrectomized (UNx) db/db mouse model of diabetic kidney disease (DKD) recapitulates…”
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5826 NEPHROPROTECTIVE EFFECTS OF SEMAGLUTIDE IN A MOUSE MODEL OF HYPERTENSION-ACCELERATED DIABETIC KIDNEY DISEASE by Christensen, Michael, Dalbøge, Louise S, Madsen, Martin Rønn, Hansen, Henrik Björk, Ida, Rune, Østergaard, Mette Viberg

“…Abstract Background and Aims Obesity, hyperglycemia and hypertension are critical risk factors for development of diabetic kidney disease (DKD). Emerging…”
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