Investigation of the effects of pentoxifylline and alpha tocopherol treatment on recovery in rats with Achilles tendon rupture

Although the Achilles tendon is the largest and strongest tendon in the body, healing of the Achilles tendon is the most common injury, and this process is difficult due to poor tendon circulation; moreover, the underlying mechanism has not been fully elucidated. In our study, we aimed to investigat...

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Bibliographic Details
Published in:	Journal of orthopaedic research Vol. 42; no. 9; pp. 1907 - 1915
Main Authors:	Toker, Mustafa, Karaduman, Zekeriya Okan, Arıcan, Mehmet, Turhan, Yalçın, Coşkun, Sinem Kantarcıoğlu, Dalaslan, Raşit Emin, Çelik, Mücahit, Uludağ, Veysel
Format:	Journal Article
Language:	English
Published:	United States 01-09-2024
Subjects:	Achilles Tendon - drug effects Achilles Tendon - injuries alpha-Tocopherol - pharmacology alpha-Tocopherol - therapeutic use alpha‐tocopherol Animals Antioxidants - pharmacology Antioxidants - therapeutic use Biomechanical Phenomena Collagen - metabolism Drug Therapy, Combination inflammation Male pentoxifylline Pentoxifylline - pharmacology Pentoxifylline - therapeutic use Rats Rats, Wistar Rupture - drug therapy tendon healing Tendon Injuries - drug therapy vasculature Wound Healing - drug effects vasculature pentoxifylline alpha‐tocopherol tendon healing inflammation
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Summary:	Although the Achilles tendon is the largest and strongest tendon in the body, healing of the Achilles tendon is the most common injury, and this process is difficult due to poor tendon circulation; moreover, the underlying mechanism has not been fully elucidated. In our study, we aimed to investigate the effects of pentoxifylline and alpha‐tocopherol administered separately or in combination on rats with Achilles tendon injury. Forty‐eight male Wistar rats weighing 230 ± 30 g were used in the study. The rats were randomly divided into eight groups of six animals each. Tendons were evaluated histopathologically and biomechanically. According to the statistical analysis, the vascularity density in the pentoxifylline group on day 14 was significantly greater than that in the other groups (p < 0.05). The collagen arrangement in the pentoxifylline and alpha‐tocopherol groups on day 14 was found to be firmer and smoother than that in the control group (p < 0.05). The collagen arrangement in the pentoxifylline group on day 28 was greater than that in the other groups (p < 0.05). The biomechanical results were significantly greater in all groups (p < 0.05). Pentoxifylline contributed to tendon healing both through neovascularization in the early period and by improving collagen orientation in the late period, while alpha‐tocopherol had a positive effect on collagen orientation in the early period. No beneficial effects were observed when pentoxifylline and alpha‐tocopherol were used together. We believe that further research is needed to understand the effects of this combination therapy on tendon healing.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0736-0266 1554-527X 1554-527X
DOI:	10.1002/jor.25844