Association of Human Leukocyte Antigen DQ1 and Dengue Fever in a White Southern Brazilian Population
Dengue is an infectious disease of viral etiology transmitted by the mosquitoes Aedes aegypti , A. albopictus, and A. scutellaris. It can develop either as a benign form or as a severe hemorrhagic form. Previous work showed an association of the hemorrhagic form with human leukocyte antigens (HLA),...
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| Published in: | Memórias do Instituto Oswaldo Cruz Vol. 99; no. 6; pp. 559 - 562 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Brazil
Fundação Oswaldo Cruz, Fiocruz
01-10-2004
Instituto Oswaldo Cruz, Ministério da Saúde Fundação Oswaldo Cruz (FIOCRUZ) |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Dengue is an infectious disease of viral etiology transmitted by the
mosquitoes Aedes aegypti , A. albopictus, and A. scutellaris. It can
develop either as a benign form or as a severe hemorrhagic form.
Previous work showed an association of the hemorrhagic form with human
leukocyte antigens (HLA), suggesting a role of genetic factors in
disease susceptibility. Nevertheless, data on HLA association with the
classical form of the disease is scarce in literature. Sixty-four
patients and 667 normal individuals, living in the state of
Paraná, Southern Brazil, were used as test and control group,
respectively. The patients developed the disease during a virus 1
dengue outbreak either in Maringá city in 1995 (47) or in
Paranavaí city in 1999 (17). The diagnostic was confirmed through
serology and/or viral culture. HLA class I and II typing was performed
by the classical microlynfocitotoxicity test using monoclonal antisera
and fluorobeads. Qui-square statistical analysis confirmed a positive
association with HLA-DQ1 (76.6% vs 57.7%; p = 0.005243; pc = 0.026215).
HLA-DR1 also presented an increased frequency in the test group, not
statistically significant after p correction though (32.8% vs 15.9%; p
= 0.005729; pc = 0.080206). In conclusion, genetic factors may play a
role on the susceptibility to the classical dengue, virus 1, in the
Brazilian population. Further independent studies should be performed
in the Brazilian population to confirm these preliminary data. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| ISSN: | 1678-8060 0074-0276 0074-0276 1678-8060 |
| DOI: | 10.1590/s0074-02762004000600003 |