Demographic pattern of A1/A2 beta casein variants indicates conservation of A2 type haplotype across native cattle breeds (Bos indicus) of India

Demographic pattern of A1/A2 beta casein variants indicates conservation of A2 type haplotype across native cattle breeds (Bos indicus) of India

Genetic variations of the beta casein gene hold importance because of their probable association with human health. Comparative sequence analysis of β–casein gene across Indian native, crossbred and exotic breeds in India revealed 15 SNPs and 4 INDELs corresponding to 14 haplotypes. The frequency of...

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Bibliographic Details
Published in:3 Biotech Vol. 12; no. 8; p. 167
Main Authors: Mukesh, Manishi, Swami, Shelesh, Bhakhri, Gaurav, Chaudhary, Vipul, Sharma, Vishal, Goyal, Nikita, Vivek, Prince, Dalal, Vijaya, Mohanty, A. K., Kataria, R. S., Kumari, Parvesh, Niranjan, Saket K., Sodhi, Monika
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01-08-2022
Springer Nature B.V
Subjects:
Agriculture
Alleles
Bioinformatics
Biomaterials
Biotechnology
Bos taurus indicus
Breeding
Cancer Research
Casein
Cattle
Chemistry
Chemistry and Materials Science
Genetic diversity
Genotypes
Haplotypes
Original
Original Article
Sequence analysis
Single-nucleotide polymorphism
Stem Cells
India
Haplotypes
Beta Casein
Indian native cattle
A1/A2 Alleles
Crossbred population
Genetic Variants
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Summary:Genetic variations of the beta casein gene hold importance because of their probable association with human health. Comparative sequence analysis of β–casein gene across Indian native, crossbred and exotic breeds in India revealed 15 SNPs and 4 INDELs corresponding to 14 haplotypes. The frequency of A2 type haplotype was maximum (0.941) across all Indian native breeds. Among the 15 variants reported for taurine breeds, only three (A1, A2 and B) were observed in analysed populations. Allelic profiling of A1/A2 β–casein variants in ~ 4000 animals belonging to three cattle types and breeding bulls also revealed the predominance of A2 allele (0.95) in Indian cattle. The high proportion of A2 allele/haplotype indicates that Indian native cattle are the best suited to meet the demands for A2 milk globally. However, a higher percentage of heterozygous genotype (A1A2) in breeding bulls warrants the need to screen sire lines so as to drift the herd towards A2.
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ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-022-03232-0