Tissue autoantibodies during therapy with levamisole for rheumatoid arthritis

In 20 patients affected with rheumatoid arthritis, tissue autoantibodies were studied during a year of treatment with levamisole. Before therapy, antinuclear antibodies were present in 11 cases, anti-thyroid microsomes in 1 and anti-smooth muscle in 6. During therapy, autoantibodies remained almost...

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Bibliographic Details
Published in:	Bollettino della Societa italiana di biologia sperimentale Vol. 58; no. 7; p. 407
Main Authors:	Cozzi, F, Ruffatti, A, Dalla Santa, G, Dal Molin, I, Fiocco, U, Todesco, S
Format:	Journal Article
Language:	Italian
Published:	Italy 15-04-1982
Subjects:	Antibodies, Antinuclear - analysis Antibody Formation - drug effects Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Autoantibodies - analysis Humans Levamisole - therapeutic use Muscle, Smooth - immunology Thyroid Gland - immunology
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Summary:	In 20 patients affected with rheumatoid arthritis, tissue autoantibodies were studied during a year of treatment with levamisole. Before therapy, antinuclear antibodies were present in 11 cases, anti-thyroid microsomes in 1 and anti-smooth muscle in 6. During therapy, autoantibodies remained almost unchanged in all patients, thus indicating that levamisole does not influence this aspect of humoral immunity in rheumatoid arthritis. Furthermore, no correlation was found between autoantibody pattern before treatment and effects of levamisole on clinical course of disease.
ISSN:	0037-8771