Search Results - "Dal Canto, MC"

Conversion to the Amyotrophic Lateral Sclerosis Phenotype Is Associated with Intermolecular Linked Insoluble Aggregates of SOD1 in Mitochondria by Deng, Han-Xiang, Shi, Yong, Furukawa, Yoshiaki, Zhai, Hong, Fu, Ronggen, Liu, Erdong, Gorrie, George H., Khan, Mohammad S., Hung, Wu-Yen, Bigio, Eileen H., Lukas, Thomas, Canto, Mauro C. Dal, O'Halloran, Thomas V., Siddique, Teepu

“…Twenty percent of the familial form of amyotrophic lateral sclerosis (ALS) is caused by mutations in the Cu, Zn-superoxide dismutase gene (SOD1) through the…”
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A virus-induced molecular mimicry model of multiple sclerosis by Olson, J K, Croxford, J L, Calenoff, M A, Dal Canto, M C, Miller, S D

“…Molecular mimicry is the process by which virus infection activates T cells that are cross-reactive with self antigens. Infection of SJL/J mice with the…”
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De Novo Central Nervous System Processing of Myelin Antigen Is Required for the Initiation of Experimental Autoimmune Encephalomyelitis by Tompkins, Stephen Mark, Padilla, Josette, Dal Canto, Mauro C, Ting, Jenny P.-Y, Van Kaer, Luc, Miller, Stephen D

“…We demonstrate the absolute requirement for a functioning class II-restricted Ag processing pathway in the CNS for the initiation of experimental autoimmune…”
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Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis by McRae, B L, Vanderlugt, C L, Dal Canto, M C, Miller, S D

“…The role of epitope spreading in the pathology of relapsing-remitting experimental autoimmune encephalomyelitis (R-EAE) was examined. Using peripherally…”
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Motor Neuron Degeneration in Mice That Express a Human Cu,Zn Superoxide Dismutase Mutation by Gurney, Mark E., Pu, Haifeng, Chiu, Arlene Y., Mauro C. Dal Canto, Polchow, Cynthia Y., Alexander, Denise D., Caliendo, Jan, Hentati, Afif, Kwon, Young W., Deng, Han-Xiang, Chen, Wenje, Zhai, Ping, Sufit, Robert L., Siddique, Teepu

“…Mutations of human Cu,Zn superoxide dismutase (SOD) are found in about 20 percent of patients with familial amyotrophic lateral sclerosis (ALS). Expression of…”
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Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS) by Dal Canto, Mauro C., Gurney, Mark E.

“…Two different lines of mice, G1 and G20, carrying a transgene for a mutant form of Cu,Zn SOD, found in a family with familial amyotrophic lateral sclerosis…”
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Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis by Dal Canto, MC, Gurney, ME

“…Transgenic mice expressing mutant Cu,Zn superoxide dismutase (SOD), containing a substitution of glycine at position 93 by alanine, develop disease prevalently…”
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Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis by Howard, L M, Miga, A J, Vanderlugt, C L, Dal Canto, M C, Laman, J D, Noelle, R J, Miller, S D

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) in the SJL mouse is a Th1-mediated autoimmune demyelinating disease model for human multiple…”
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A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade by Girvin, Ann M, Dal Canto, Mauro C, Rhee, Lesley, Salomon, Benoit, Sharpe, Arlene, Bluestone, Jeffrey A, Miller, Stephen D

“…The B7/CD28 pathway provides critical costimulatory signals required for complete T cell activation and has served as a potential target for immunotherapeutic…”
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Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis by Suvannavejh, G C, Dal Canto, M C, Matis, L A, Miller, S D

“…PLP139-51-induced experimental autoimmune encephalomyelitis (R-EAE) displays a relapsing-remitting paralytic course in female SJL mice. We investigated the…”
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Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis by Suvannavejh, G C, Lee, H O, Padilla, J, Dal Canto, M C, Barrett, T A, Miller, S D

“…To clarify the role of tumor necrosis factor (TNF) in the inflammatory aspects of autoimmunity vs its potential role in the apoptotic elimination of…”
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Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE by Miller, Stephen D., Vanderlugt, Carol L., Lenschow, Deborah J., Pope, Jonathan G., Karandikar, Nitin J., Dal Canto, Mauro C., Bluestone, Jeffrey A.

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) induced with the immunodominant epitope from proteolipid protein, PLP 139–151, is characterized by…”
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Gender Bias in Theiler's Virus-Induced Demyelinating Disease Correlates with the Level of Antiviral Immune Responses by Fuller, Alyson C, Kang, Bongsu, Kang, Hee Kap, Yahikozowa, Hiroyuki, Dal Canto, Mauro C, Kim, Byung S

“…Multiple sclerosis is an immune-mediated disease of the CNS and shows a sex-biased distribution in which 60-75% of all cases are female. A mouse model of…”
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The Golgi Apparatus of Spinal Cord Motor Neurons in Transgenic Mice Expressing Mutant Cu,Zn Superoxide Dismutase Becomes Fragmented in Early, Preclinical Stages of the Disease by Mourelatos, Zissimos, Gonatas, Nicholas K., Stieber, Anna, Gurney, Mark E., Mauro C. Dal Canto

“…Dominant mutations of the SOD1 gene encoding Cu,Zn superoxide dismutase have been found in members of certain families with familial amyotrophic lateral…”
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Astrocytes, not microglia, are the main cells responsible for viral persistence in Theiler's murine encephalomyelitis virus infection leading to demyelination by Zheng, Lili, Calenoff, Miriam A., Dal Canto, Mauro C.

“…The BeAn strain of Theiler's murine encephalomyelitis virus (TMEV) persists in the CNS and produces a chronic inflammatory demyelinating disease that is an…”
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Transcription from the Gene Encoding the Herpesvirus Entry Receptor Nectin-1 (HveC) in Nervous Tissue of Adult Mouse by Haarr, Lars, Shukla, Deepak, Rødahl, Eyvind, Dal Canto, Mauro C., Spear, Patricia G.

“…Both human and murine forms of nectin-1 (HveC, Prr1) can serve as entry receptors for several neurotropic herpesviruses, including herpes simplex viruses 1 and…”
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Age-Dependent Penetrance of Disease in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis by Chiu, Arlene Y., Zhai, Ping, Dal Canto, Mauro C., Peters, Theresa M., Kwon, Young W., Prattis, Susan M., Gurney, Mark E.

“…The mutation gly93 → ala of Cu,Zn superoxide dismutase (SOD) is found in patients with familial amyotrophic lateral sclerosis and causes motor neuron disease…”
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Striking Similarity of Murine Nectin-1α to Human Nectin-1α (HveC) in Sequence and Activity as a Glycoprotein D Receptor for Alphaherpesvirus Entry by Shukla, Deepak, Dal Canto, Mauro C., Rowe, Cynthia L., Spear, Patricia G.

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Altered neurovirulence of temperature-sensitive vesicular stomatitis virus mutants in a murine model by inoculation of bombesin: a neuropeptide. I. Clinical, virological and pathological observations by Huprikar, J, Dal Canto, M C, Rabinowitz, S G

“…Previous work in our laboratory has demonstrated that only certain temperature-sensitive (ts) mutants of vesicular stomatitis virus (VSV) appear capable of…”
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Effect of Disease Stage on Clinical Outcome After Syngeneic Bone Marrow Transplantation for Relapsing Experimental Autoimmune Encephalomyelitis by Burt, Richard K., Padilla, Josette, Begolka, Wendy Smith, Canto, Mauro C. Dal, Miller, Stephen D.

“…Relapsing experimental autoimmune encephalomyelitis (R-EAE) is an immune-mediated demyelinating central nervous system (CNS) disease. Myeloablation and…”
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