Search Results - "Dakin, A"

Birth preferences and delivery outcomes after previous obstetric anal sphincter injury by Dakin, A., Eogan, M.

Get full text

Identification of (R)‑N‑((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)‑1H‑indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B‑Cell Lymphomas by Vaswani, Rishi G, Gehling, Victor S, Dakin, Les A, Cook, Andrew S, Nasveschuk, Christopher G, Duplessis, Martin, Iyer, Priyadarshini, Balasubramanian, Srividya, Zhao, Feng, Good, Andrew C, Campbell, Robert, Lee, Christina, Cantone, Nico, Cummings, Richard T, Normant, Emmanuel, Bellon, Steven F, Albrecht, Brian K, Harmange, Jean-Christophe, Trojer, Patrick, Audia, James E, Zhang, Ying, Justin, Neil, Chen, Shuyang, Wilson, Jon R, Gamblin, Steven J

“…Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of…”
Get full text

Evolution of the aging brain transcriptome and synaptic regulation by Loerch, Patrick M, Lu, Tao, Dakin, Kelly A, Vann, James M, Isaacs, Adrian, Geula, Chengiz, Wang, Jianbin, Pan, Ying, Gabuzda, Dana H, Li, Cheng, Prolla, Tomas A, Yankner, Bruce A

“…Alzheimer's disease and other neurodegenerative disorders of aging are characterized by clinical and pathological features that are relatively specific to…”
Get full text

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia by Keeton, Erika K., McEachern, Kristen, Dillman, Keith S., Palakurthi, Sangeetha, Cao, Yichen, Grondine, Michael R., Kaur, Surinder, Wang, Suping, Chen, Yuching, Wu, Allan, Shen, Minhui, Gibbons, Francis D., Lamb, Michelle L., Zheng, Xiaolan, Stone, Richard M., DeAngelo, Daniel J., Platanias, Leonidas C., Dakin, Les A., Chen, Huawei, Lyne, Paul D., Huszar, Dennis

“…Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2, and -3 promote cell proliferation and survival downstream of…”
Get full text

VP52.07: Cut‐offs of cervical length versus gestation‐specific centiles: impact on patient care by O'Reilly, P., Dakin, A., Corcoran, S.M.

Get full text

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR) by Ward, Richard A, Anderton, Mark J, Ashton, Susan, Bethel, Paul A, Box, Matthew, Butterworth, Sam, Colclough, Nicola, Chorley, Christopher G, Chuaqui, Claudio, Cross, Darren A. E, Dakin, Les A, Debreczeni, Judit É, Eberlein, Cath, Finlay, M. Raymond V, Hill, George B, Grist, Matthew, Klinowska, Teresa C. M, Lane, Clare, Martin, Scott, Orme, Jonathon P, Smith, Peter, Wang, Fengjiang, Waring, Michael J

“…A novel series of small-molecule inhibitors has been developed to target the double mutant form of the epidermal growth factor receptor (EGFR) tyrosine kinase,…”
Get full text

Severe maternal morbidity trends over 20 years in a tertiary referral stand-alone maternity unit by Dakin, A., Clinton, S., Sloan, J., Dicker, P., Byrne, B.M.

“…•The rate of SMM has increased threefold over 20 years.•ICU transfer rates more than double.•Peripartum hysterectomy rates remain stable. Severe maternal…”
Get full text

CytoLyt® fixation and decalcification pretreatments alter antigenicity in normal tissues compared with standard formalin fixation by Gruchy, Jennette R, Barnes, Penny J, Dakin Haché, Kelly A

“…Immunohistochemistry is used on cell blocks constructed from cytopathology samples fixed in methanol-based fixatives, such as CytoLyt (Cytyc Corp), and on…”
Get full text

A randomised controlled trial of the clinical effectiveness and cost-effectiveness of different knee prostheses: the Knee Arthroplasty Trial (KAT) by Murray, David W, MacLennan, Graeme S, Breeman, Suzanne, Dakin, Helen A, Johnston, Linda, Campbell, Marion K, Gray, Alastair M, Fiddian, Nick, Fitzpatrick, Ray, Morris, Richard W, Grant, Adrian M

“…In the late 1990s, new developments in knee replacement were identified as a priority for research within the NHS. The newer forms of arthroplasty were more…”
Get full text

A randomised controlled trial to assess the clinical effectiveness and cost-effectiveness of alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN) by Chakravarthy, Usha, Harding, Simon P, Rogers, Chris A, Downes, Susan, Lotery, Andrew J, Dakin, Helen A, Culliford, Lucy, Scott, Lauren J, Nash, Rachel L, Taylor, Jodi, Muldrew, Alyson, Sahni, Jayashree, Wordsworth, Sarah, Raftery, James, Peto, Tunde, Reeves, Barnaby C

“…Bevacizumab (Avastin®, Roche), which is used in cancer therapy, is the 'parent' molecule from which ranibizumab (Lucentis®, Novartis) was derived for the…”
Get full text

Severe Maternal Morbidity and the Impact of the Covid Pandemic by Al Sayegh, K, Dakin, A, Clinton, S, Sloan, J, Byrne, B M

Get full text

Perineal hernia repair using a bone fixation anchoring system for the mesh – a video vignette by Stamatiou, D., Dakin, A., Khalil, H., Raju, T., Fernandes, R., Bowley, D., Karandikar, S.

Get full text

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases by Dakin, Les A., Block, Michael H., Chen, Huawei, Code, Erin, Dowling, James E., Feng, Xiaomei, Ferguson, Andrew D., Green, Isabelle, Hird, Alexander W., Howard, Tina, Keeton, Erika K., Lamb, Michelle L., Lyne, Paul D., Pollard, Hannah, Read, Jon, Wu, Allan J., Zhang, Tao, Zheng, Xiaolan

“…Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The…”
Get full text

Astrocytes Promote Myelination in Response to Electrical Impulses by Ishibashi, Tomoko, Dakin, Kelly A., Stevens, Beth, Lee, Philip R., Kozlov, Serguei V., Stewart, Colin L., Fields, R. Douglas

“…Myelin, the insulating layers of membrane wrapped around axons by oligodendrocytes, is essential for normal impulse conduction. It forms during late stages of…”
Get full text

Early evaluation of acute traumatic coagulopathy by thrombelastography by Carroll, Roger C, Craft, Robert M, Langdon, Russell J, Clanton, Colin R, Snider, Carolyn C, Wellons, Douglas D, Dakin, Patrick A, Lawson, Christy M, Enderson, Blaine L, Kurek, Stanley J

“…Posttraumatic coagulopathy is a major cause of morbidity. This prospective study evaluated the thrombelastography (TEG) system and PlateletMapping (Haemoscope…”
Get full text

[4 + 2]-Annulations of Chiral Organosilanes:  Application to the Total Synthesis of Leucascandrolide A by Su, Qibin, Dakin, Les A, Panek, James S

“…Complete details of an asymmetric synthesis of leucascandrolide A (1) are described. The synthesis highlights the use of two diastereoselective [4 +…”
Get full text

Who gets referred for knee or hip replacement? A theoretical model of the potential impact of evidence-based referral thresholds using data from a retrospective review of clinic records from an English musculoskeletal referral hub by Dakin, Helen A, Eibich, Peter, Gray, Alastair, Smith, James, Barker, Karen L, Beard, David, Price, Andrew J

“…ObjectivesTo estimate the relationship between patient characteristics and referral decisions made by musculoskeletal hubs, and to assess the possible impact…”
Get full text

Partial factorial trials: comparing methods for statistical analysis and economic evaluation by Dakin, Helen A, Gray, Alastair M, MacLennan, Graeme S, Morris, Richard W, Murray, David W

“…Partial factorial trials compare two or more pairs of treatments on overlapping patient groups, randomising some (but not all) patients to more than one…”
Get full text

A Systematic Review and Mixed Treatment Comparison of the Efficacy of Pharmacological Treatments for Fibromyalgia by Choy, Ernest, MD, Marshall, David, MD, Gabriel, Zahava L., PhD, Mitchell, Stephen A., PhD, Gylee, Elizabeth, MSc, Dakin, Helen A., MSc

“…Objectives To review the literature on pharmacological treatments for fibromyalgia. Methods Relative efficacy was estimated in terms of outcome measures…”
Get full text

Scope and Safety of Paediatric Surgery in a Model III Hospital by Joyce, D P, Craig, R, Dakin, A, Elsheik, H, Ejaz, T, Mansoor, S, Toomey, D P

“…Introduction Elective and emergency paediatric general surgery is performed in numerous hospitals but with differing exclusion and transfer thresholds. Recent…”
Get full text