Search Results - "Daitchman, Dina"
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Does PCNA diffusion on DNA follow a rotation-coupled translation mechanism?
Published in Nature communications (05-10-2020)Get full text
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Diffusion of ring-shaped proteins along DNA: case study of sliding clamps
Published in Nucleic acids research (06-07-2018)“…Abstract Several DNA-binding proteins, such as topoisomerases, helicases and sliding clamps, have a toroidal (i.e. ring) shape that topologically traps DNA,…”
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Identification of a potent and selective covalent Pin1 inhibitor
Published in Nature chemical biology (01-09-2020)“…Peptidyl-prolyl cis / trans isomerase NIMA-interacting 1 (Pin1) is commonly overexpressed in human cancers, including pancreatic ductal adenocarcinoma (PDAC)…”
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Abstract 6241: A large scale proteogenomic atlas for precision oncology research
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Recent advances in the field of mass spectrometry proteomics have led to growth in proteomics research resulting in a massive and rapid increase in…”
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Abstract 1855: Proteomics driven biomarker discovery for high-grade serous ovarian carcinoma from archived tissue specimens
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract High-Grade Serous Ovarian Carcinoma (HGSOC) is a highly aggressive and heterogeneous cancer with variable treatment responses. Current treatment…”
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Abstract 2757: Discovery and characterization of covalent Pin1 inhibitors targeted to an active site cysteine
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Abstract Proline-directed phosphorylation at serine or threonine residues (pSer/Thr-Pro) regulates numerous cellular processes, including the cell cycle,…”
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Abstract 5130: Phospho-proteomic dynamics reveal DNA damage and repair signatures of drug sensitivity
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract There are numerous drug development efforts of DNA damage response (DDR) targets, such as PARP, ATR, ATM, CHK1, where the ability to accurately…”
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